DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and arhgef11

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001027010.1	Gene:	arhgef11 / 565268	ZFINID:	ZDB-GENE-070604-1	Length:	1417	Species:	Danio rerio

Alignment Length:	653	Identity:	142/653 - (21%)
Similarity:	238/653 - (36%)	Gaps:	186/653 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCR 136
            |...|.:|...:|     ..:.|:|.  |:...:||:.:| |.::.:...:........|||..:
Zfish   473 LSKHEEDRSSPLA-----SAVHLYLR--HSGIKLRDSKVF-PGLMSEKEKWLPFFPKAKKLSSAK 529

  Fly   137 KV-----QQLHPDL--IG---------FNLQLSPTE-RSHSDEAIYKDLHSTDLNMRKTSSIDAS 184
            :.     ::.:|.|  ||         |::.||||| |..|...|.:...|.
Zfish   530 RERDGEDKKRNPILKYIGKPRSTSQSTFHVPLSPTEVRPGSVRNIIQQFESN------------- 581

  Fly   185 ASSSAEYYDRTSQ--SGSLDENSDITIENGTEDIDDYIEDSLSNMCD---------------STI 232
             |.|.|..:...|  |||..|:|   :|:.|..:.....:||....:               |..
Zfish   582 -SDSLEDGELEGQRLSGSFGEDS---MESPTISVRLARSESLKAQGEGRRRGGGTGAEFVPRSRS 642

  Fly   233 DNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAP 297
            |.|.||.       .:.:|..:|.|....:....||:.....|   ||| .|..:||..:.
Zfish   643 DVDMEDC-------EEREGPGLRPLHHSASSSASSSSARSLEN---PTP-PYTPRSQRRIV---- 692

  Fly   298 SVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKV 362
            .||||..|..|                           |:                     ||.|
Zfish   693 EVPVSLLPDAP---------------------------AL---------------------DEDV 709

  Fly   363 YEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFE-QRD 426
            .:                         .::..:|.|..:              .||.||.| .|.
Zfish   710 ID-------------------------SHNWQDTVEPHI--------------LASLTSREIDRQ 735

  Fly   427 YVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKF---LDKLRESL 488
            .||.||..||.::|..|..|...|...::..|:.:||..||..:|::.::|...   :.|.|||:
Zfish   736 AVIYELFTTEVSHLRTLRVLDQVFYQKMQSVLSPEELSCIFLNLRQVYELHASLCESMKKCRESV 800

  Fly   489 TPNAKVKMAQVFL---------DFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERD 544
            ....   :..:.|         .|.|.   ....||....|::.:.:..:|:.....|:|:||..
Zfish   801 IVQG---IGDIMLARFEGEAGDQFEEQ---VSHLCSQQSPALELIKNKQRKDPRFAHLIQECEAS 859

  Fly   545 YNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSD 609
            .:..:|||:|:|...|||:.||.||||.::|.|.....|...|.||:.....:.|.:||..|:::
Zfish   860 PHCRRLQLKDLLVSEMQRLTKYPLLLDNIIKYTETSSPDLPLLRRAQACCRGILQEVNEDVRETE 924

  Fly   610 HLVIIQKVKDSI--CDIHLLQNGNGSDL----LQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKI 668
            |..::.:.:..:  ..:..|.|...:..    |...|::.:|.|..:..:|:..:::...:.|.:
Zfish   925 HRHLLSQYQRRLDATPLERLANPVAAQFRNLDLTTKRMVHEGPLTWRVGKDKAIEIQALLLSDLL 989

  Fly   669 LIM 671
            |::
Zfish   990 LLL 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	11/59 (19%)
		RhoGEF	428..603	CDD:279015	53/186 (28%)
		PH_Vav	624..753	CDD:269930	9/52 (17%)
		PH	641..749	CDD:278594	5/31 (16%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
arhgef11	NP_001027010.1	PDZ_signaling	49..123	CDD:238492
		DegQ	<71..140	CDD:223343
		RGS_PDZRhoGEF	300..446	CDD:188707
		RhoGEF	737..918	CDD:279015	53/186 (28%)
		PH-like	935..1075	CDD:302622	9/58 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910