DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and shdb

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009294545.1	Gene:	shdb / 564537	ZFINID:	ZDB-GENE-030131-6059	Length:	417	Species:	Danio rerio

Alignment Length:	199	Identity:	46/199 - (23%)
Similarity:	76/199 - (38%)	Gaps:	41/199 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 KWRKA-LTEAMESLE--------PPGCQSTDHKM--EIYTFDAPTTCRHCSKFLKGRIHQGYRCK 792
            :|:|. :::|...::        ||..|..:..:  |...|:.....|.||.      .:..||.
Zfish   223 EWKKEHISKAFADMKDLSELPWPPPVGQLEEEPICGEQVQFEGAEWDRSCSP------TERLRCS 281

  Fly   793 VCQISVHKGCISSTGRCKQNPVSVPPPVCDRQ------LSEFNWFAGNMDRETAAHRLENRRIGT 851
            ...        .:||..|....|.|..:...:      |.:..|:.|::.|..|...|...:..:
Zfish   282 RAP--------PTTGSMKLRKPSDPHSMIGERVDPSLPLEKQVWYHGSLSRSEAESLLTLCKECS 338

  Fly   852 YLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRR-HFKTIVELVSYYE 915
            ||:|     .|......|:|||::....: |||.:|...|   .|.|.... .|:||.|::.||.
Zfish   339 YLVR-----NSETSRLDYSLSLRSCQGFM-HMKFSQCKDG---RYILGQNSPPFETIPEVIHYYT 394

  Fly   916 RNDL 919
            .:.|
Zfish   395 THKL 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	3/22 (14%)
		PH	641..749	CDD:278594	3/10 (30%)
		C1_1	761..804	CDD:278556	7/44 (16%)
		SH2_Vav_family	824..934	CDD:198193	28/103 (27%)
		SH3	940..993	CDD:302595
shdb	XP_009294545.1	SH2_SHB_SHD_SHE_SHF_like	315..412	CDD:198198	27/93 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910