DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and plekhg6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009290476.1	Gene:	plekhg6 / 563725	ZFINID:	ZDB-GENE-030131-2517	Length:	1025	Species:	Danio rerio

Alignment Length:	492	Identity:	107/492 - (21%)
Similarity:	185/492 - (37%)	Gaps:	95/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 AVYNYRSSMASTEHEYAYI-YSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEE 399
            ||.:.....|..:|.|..| |.:..::...|...|:..|..|.......:..|....|...|.||
Zfish    50 AVASTGQRRAQEKHRYNTIGYQKKKQRTNVDFSTVSKGAGVKSRGALKQVLFNQGTNDKNGTVEE 114

  Fly   400 ---------EVYQDLC--------------------ALHR--TSRSQTASSTSFEQR--DYVIRE 431
                     :|.:.|.                    ||.:  |....:..|.|..||  ...:.|
Zfish   115 RLGGVQGQVDVLKQLLDSFSVPADLRWTWGEGGTERALEKSWTEIVHSHESMSKTQRLQQEALWE 179

  Fly   432 LIDTESNYLDVLTALKTKFMGPLER-HLN----QDELRLIFPRIRELVDIHTKF--------LDK 483
            |::||..|::.||..|...:..|.. |||    :....::|..:..::|.|..|        |.:
Zfish   180 LLNTELTYINKLTIAKDLVLAALSYCHLNGFLQEVSPTMLFSDLPSILDAHRLFWHDVMYPMLQE 244

  Fly   484 LRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVG 548
            :|.:..|...:|:....|.|.:.|..|.::|......::......:.|......:...|.....|
Zfish   245 VRLTGRPFDPMKLEPGCLQFHKRFPAYFDYCFEGDRNVELTRKQLETNPQFYTYLMWVENHPQCG 309

  Fly   549 KLQLRDILSVPMQRILKYHLLLDKLVKETSPLH-------------------DDYRSLERAKEAM 594
            :::|.|:.:.|.|||.||.|||..:.|.|..|.                   :||..|:..:.|:
Zfish   310 RMRLGDMQAKPHQRITKYPLLLKAVQKTTEDLPAKIALDRMLNSVNNFVQSINDYLQLKADELAL 374

  Fly   595 IDVSQYINEVKRDSDHLVIIQKVKDSIC--DIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKT 657
            ..::|.|...|.:.....:.:.|:: ||  |:....:|.|.::::  :.:|:..|.:|..:|  |
Zfish   375 SAIAQRIEGYKIEGLSEEVDKHVRE-ICRFDLTSPMSGVGPNVIR--KQILEETLKVKRRKD--T 434

  Fly   658 KLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYR----VEQSHSRRTIGRDTRFKYQLLL 718
            |.....:|..:|::.||           .:.|..|...|    ||:.|   .|.....:.:.|:.
Zfish   435 KEFVVLLFTDVLLITKA-----------QKKSDKLKVLRPPMLVERIH---CIEVKDGYSFMLVE 485

  Fly   719 ARKSGKTAFTLYLKSEHERD---KWRKALTEAMESLE 752
            ....| ...::::.|....|   .|..||.|..|:|:
Zfish   486 VGDLG-CPLSVHIMSTPSPDSCASWVSALRETQEALQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/206 (23%)
		PH_Vav	624..753	CDD:269930	29/136 (21%)
		PH	641..749	CDD:278594	25/114 (22%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
plekhg6	XP_009290476.1	RhoGEF	176..363	CDD:279015	42/186 (23%)
		PH-like	418..514	CDD:302622	23/114 (20%)
		PH	421..515	CDD:278594	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910