DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and Net1

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_062645.2 Gene:Net1 / 56349 MGIID:1927138 Length:595 Species:Mus musculus


Alignment Length:571 Identity:120/571 - (21%)
Similarity:203/571 - (35%) Gaps:146/571 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 DITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLAL-DVVSST 269
            |.|::....:.||   |::|.   |::|            |.:.....||.|:...:| :::|..
Mouse    62 DFTLKRKRREKDD---DAVSL---SSLD------------LKEPSNKRVRPLARVTSLANLISPV 108

  Fly   270 TDGASNAVTPTPESYARQS--QSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQR 332
            .:||......|.:|:..:.  :|| |:|..|...|..|.|...|        ||.|.||...:  
Mouse   109 RNGAVRRFGQTIQSFTLRGDHRSP-ASAQKSFSRSTVPTPTKRR--------SSALWSEMLDI-- 162

  Fly   333 AAAAVYNYRSSMASTE---HEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHT 394
                  |.:.|:.:.|   .|..|..|..::.:.|||                .:|         
Mouse   163 ------NMKESLTTREIKRQEAIYELSRGEQDLIEDL----------------KLA--------- 196

  Fly   395 NTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLN 459
                .:.|.|                                       ..||...|       :
Mouse   197 ----RKAYHD---------------------------------------PMLKLSIM-------S 211

  Fly   460 QDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKV-KMAQVFLDFREPFLIYGEFCSLLLGAIDY 523
            ::||..||..:...:.:|...|.::.|:..|:..| ::..:.:::......|..:||..|.| ..
Mouse   212 EEELTHIFGDLDAYIPLHEDLLARIGEATKPDGTVEQIGHILVNWLPGLNAYRGYCSNQLAA-KA 275

  Fly   524 LADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLE 588
            |.|..|::..:...:|:|.......||.|...|.:|..|::||.|||.::::.|...|.|.:.||
Mouse   276 LLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHRDVQLLE 340

  Fly   589 RAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLL-DGELHIKAH 652
            .|...:..|...||..|.:|:....|.|       :..|........::..::|| .|||..|:.
Mouse   341 EAILIIQGVLSDINLKKGESECQYYINK-------LEYLDEKQKDPRIEASKVLLCHGELKNKSG 398

  Fly   653 EDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDS--------HNLADYRVEQSHS-RRTIGR 708
            .    || |.|:|..||::.:.:......:...||..        .:|.|..|....| |...|.
Mouse   399 H----KL-YIFLFQDILVLTRPVTRNERHLYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFGN 458

  Fly   709 DTRFK--YQLLLARKSGKTAFTLYLKSEHERDKW----RKALTEAMESLEP 753
            ..:.|  :::.....|...:.||.......:.:|    |.|:.....:..|
Mouse   459 SDKAKNIFRVRFQDPSPGHSHTLQANDVFHKQQWFNCIRAAIAPFQRAASP 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 41/175 (23%)
PH_Vav 624..753 CDD:269930 29/144 (20%)
PH 641..749 CDD:278594 28/123 (23%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
Net1NP_062645.2 Necessary for nuclear localization 1..74 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
Nuclear localization signal 12..19
Nuclear localization signal 66..72 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..151 8/24 (33%)
RhoGEF 178..354 CDD:214619 48/251 (19%)
PH_Net1 368..502 CDD:270044 30/145 (21%)
PH 387..501 CDD:278594 28/118 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..595
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.