DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and sorbs2b

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009289432.1	Gene:	sorbs2b / 563408	ZFINID:	ZDB-GENE-070308-3	Length:	1822	Species:	Danio rerio

Alignment Length:	1017	Identity:	190/1017 - (18%)
Similarity:	307/1017 - (30%)	Gaps:	410/1017 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITI 209
            |:.:|.:.:|  |...:.::|:.  |||.:..:.||   |||.:.:  .|.|:..:....:..::
Zfish   573 LLDYNPESAP--RFPVETSLYQP--STDRSFERPSS---SASDNKK--RRKSEPATTQPRAHSSV 628

  Fly   210 ENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVET---PLLSDCQGSHVRELSFDLALDVVSSTTD 271
              ||              ..:::.......|..|   ||.|....:..|....|     ||:...
Zfish   629 --GT--------------TQTSVRPPELPRGSSTQRNPLTSPSSPATTRTKGGD-----VSNMHT 672

  Fly   272 GASNAVTPTP-------ESYARQSQSPLAAAAPSVPVSAAP-------------------GPPM- 309
            ..||.::|..       ::|.....|.:|..|.|...|:.|                   .|.:
Zfish   673 AHSNCLSPNHSTSEPVYQNYGENEDSFMAVPAVSEGFSSLPEGWKPAQENSEDWMIAEETSPKLK 737

  Fly   310 ------------GRLVST-SSSSSSLL------------VSESQRLQRAAAAVYNYRSSMASTEH 349
                        ||.|.| ..|:.|||            |.||:.|:.             .|.|
Zfish   738 SWSCDDLLSEGRGREVQTRCESTGSLLHNGELETSQYCDVQESEDLRE-------------RTRH 789

  Fly   350 EYAYIYSEDDE----KVYEDLCYVT-------------------FQAKAKPEVTTDNIACNGTGY 391
            ..|:     |.    |:|:.:.::.                   ::::.:.:..|.|..||
Zfish   790 RSAH-----DAPGFLKLYKKMHHINRQELINSTVICSVKSRIRKYESEQRKDRRTGNKGCN---- 845

  Fly   392 DHTNTKEEEVYQDL------------------------CALHRTSRSQTASSTSFEQRDYVIREL 432
                   |||.:|:                        |.:..:||     ..:..:|...|..|
Zfish   846 -------EEVPRDMVHNRISEFESLIQKSKSMPNLGEECLIRGSSR-----RINSPKRSLSIESL 898

  Fly   433 IDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFL-DKLRESLTPN--AKV 494
            :|.|                |..|  |..|.|..:|:|...|.||.... |:|:.|...|  :..
Zfish   899 LDEE----------------PPAR--NPPEGRPQYPKINNHVPIHIHVTSDQLQNSAMQNDYSDS 945

  Fly   495 KMAQVFLDFREPFLIYG-EFCSLLLGAIDYLADVCK------------KNQIIDQLVQKCE---- 542
            :...|..|..:...|.| .|||      :...|:|.            .:....|||..|:
Zfish   946 EHDAVVSDLSDFIQIEGSSFCS------EREFDLCSFASSESFCGSGHHHHFHRQLVSSCKGRCP 1004

  Fly   543 -------------------------RDYNVGKLQLRDILS-VPMQRILKYHLLLDKLVKETSPLH 581
                                     .|...|..:|..::| ||.:|            |..|||
Zfish  1005 ASYTRFTTMIKHERAKQDRRQHLRVEDSEFGLSKLAFLVSPVPFRR------------KNLSPL- 1056

  Fly   582 DDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGE 646
                |..|    |.:...|:.|.            :..::.||:                  |
Zfish  1057 ----SFSR----MSNSKSYVYET------------LDSALKDIY------------------D-- 1081

  Fly   647 LHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTR 711
             ||:. |.:::.|....:..::|:.:                   |.|. .|::.|...:||::.
Zfish  1082 -HIRT-EKRRSSLSENSILHRLLVEL-------------------LPDI-PERNSSLHALGRNSP 1124

  Fly   712 FKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRH 776
                            |:..:|.|.               :|.|..|.|
Zfish  1125 ----------------TIQPRSYHP---------------QPDGMSSQD---------------- 1142

  Fly   777 CSKFLKGRIHQGYRCKVCQISVHKGCISSTGR-------CKQNPVSVPPPVCDRQLSEFNWFAGN 834
                    |||...|.:...:.|....|:..:       |.|          |:..|. |:...:
Zfish  1143 --------IHQSEYCHLSHSASHNHIDSNNNQRNHNFKYCYQ----------DQDTSR-NYTYPD 1188

  Fly   835 MDRETAAHRLENRRIGTYLLRVRPQGPSTA-----HETMYALSLKTDDNVIKHMKINQENSGDSM 894
            :.|:|...|.:..       .||.:.|:.|     .:|...|:.|..|.|....:|      |:.
Zfish  1189 VGRQTPQSRRQTP-------DVREKLPARAIYDFKAQTAKELTFKKGDTVYISRQI------DNN 1240

  Fly   895 LYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSN-QLQLRT 958
            .|  ....|....:..:||.|:....|.............|| |..|:..|...|.:| :|.||.
Zfish  1241 WY--EGEYHGHVGIFPISYVEKIPPSERHLPARPPPPAQSKE-IGEAVARYNFNADTNVELSLRK 1302

  Fly   959 DCQVLVIGKDGDSKGWWRGKIGDT--VGYFPKEYVQEQKLAS 998
            ..:|:::.:  ..|.|:.|||..|  .|.||..||...|..|
Zfish  1303 GERVVLVRQ--VDKNWFEGKIPGTNKQGIFPVSYVDVIKKTS 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	46/220 (21%)
		PH_Vav	624..753	CDD:269930	16/128 (13%)
		PH	641..749	CDD:278594	15/107 (14%)
		C1_1	761..804	CDD:278556	5/42 (12%)
		SH2_Vav_family	824..934	CDD:198193	22/114 (19%)
		SH3	940..993	CDD:302595	19/55 (35%)
sorbs2b	XP_009289432.1	Atrophin-1	<150..607	CDD:331285	11/40 (28%)
		Sorb	369..411	CDD:308043
		SH3_Sorbs2_1	1207..1261	CDD:212853	14/61 (23%)
		SH3_Sorbs2_2	1282..1338	CDD:212856	19/57 (33%)
		SH3_Sorbs2_3	1762..1822	CDD:212850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910