DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and tagln3a

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001096584.1	Gene:	tagln3a / 563096	ZFINID:	ZDB-GENE-060531-53	Length:	213	Species:	Danio rerio

Alignment Length:	157	Identity:	36/157 - (22%)
Similarity:	62/157 - (39%)	Gaps:	15/157 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLY- 117
            |..|.:||.|:..|.||..:|.:...:.:|. |...:.|..||... ..:|:...|:|:...|:
Zfish    56 LMSGTILCRLINSLYPSGEEPIKKITESKMV-FKQMEKISQFLQFA-EEYGVNRGDIFQTVDLWE 118

  Fly   118 --DLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSS 180
              |:....|.|:.|...:..:.......|...|:.:....:|..|:|.:.:.  ...:.|:..|:
Zfish   119 GKDMAAVQRTLMALGSEALTKDDGHYRGDPDWFHRKTKGHKREFSEEQLRQG--RVVIGMQMGSN 181

  Fly   181 IDASASSSAEY--------YDRTSQSG 199
            ..||.|....|        ||....:|
Zfish   182 RGASQSGMVGYGTPRQIMRYDSPRHNG 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	22/80 (28%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
tagln3a	NP_001096584.1	SCP1	14..188	CDD:227526	31/135 (23%)
		CH	25..132	CDD:278723	21/77 (27%)
		Calponin	174..197	CDD:278814	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910