DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and plekhg7

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001315140.1	Gene:	plekhg7 / 562798	ZFINID:	ZDB-GENE-070410-15	Length:	769	Species:	Danio rerio

Alignment Length:	734	Identity:	162/734 - (22%)
Similarity:	254/734 - (34%)	Gaps:	205/734 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NFHR----------VLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIY-KDLHSTDLN 174
            ||||          .|...|.:|......:..|.    .:..|||.|......|| ::..:....
Zfish   116 NFHRHSPACCSTSPALWRSSGMSYSVDFHRHSPT----RISTSPTLRRMRSTRIYNRETSNPAKP 176

  Fly   175 MRKTSSIDASASSSAEYYDRTSQSGSLDENS--DITIENGTEDIDDYIEDSLSN--MCDSTIDND 235
            :|:.||...|..||  ::...|...:.:||.  :.::..||  :..:...:|.|  :|.|....|
Zfish   177 LREESSTPMSPHSS--FFREKSPLAADEENKSPESSVTPGT--VRTHRSQTLDNGSICKSKESCD 237

  Fly   236 AEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVP 300
            ::...      ||.:                 ||||.......|..:....:.:|.:..:.|.:.
Zfish   238 SKKPA------SDKE-----------------STTDDNEQVKDPCHKRLKERRRSSVVVSLPGLD 279

  Fly   301 VSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYE- 364
            ||  ||              .|.||      ..||.:.| :|..:..:.::.:.......||..
Zfish   280 VS--PG--------------DLFVS------NGAADMLN-KSDYSEKKSKWPFSRRSTQTKVKTR 321

  Fly   365 -----DLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA---LHRTSRSQTASSTS 421
                 |.|..:.|.   ||               ....:.:.::|:..   |...|..:.|....
Zfish   322 SGADIDKCLASVQV---PE---------------WRDTDFQTFKDMSLVDFLQGRSELKAAQHPM 368

  Fly   422 FEQRDYVIRELIDTESNY-LDVLTALKTKFMGPLE----RHLNQD-ELRLIFPRIRELVDIHTKF 480
            ..:....|.||..:|..| ||.|..||..|:..|.    |...|| :...:|..:.||..:...|
Zfish   369 TYKTQEAIWELFTSECVYFLDQLMVLKEVFLTTLSDLQTRQCLQDIDSWRLFANLNELCLVSFGF 433

  Fly   481 LDKL----RESLTPNAKVKMAQVFLDFREPFL-----IYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
            |..|    :|..|.........:...||:.|.     ...::|.....||.|| |..|..:....
Zfish   434 LTSLLRVIKEMWTDPDSCSTQSLHDLFRKAFSESICHCLQKYCLNYSTAILYL-DSLKLREDFGS 497

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKE----AMID- 596
            .|:.|||:....:|||:|:|.||:||..:|.|||..:.|         ||..:|:|    :::|
Zfish   498 FVKWCERNEECRRLQLKDLLVVPLQRFTRYPLLLKNIGK---------RSCSKAEENTIQSIVDL 553

  Fly   597 VSQYINEVKRDSDHLVIIQKVK--------------DSICDI-----HLLQNGNGSDLLQYGRLL 642
            |.:.|.:::.....|...||||              |....:     |||:.....:|:....||
Zfish   554 VDRAIYDLEGKVKWLDNYQKVKQLKETLVWLPVWESDKRAHVPESLKHLLKPVTLENLVINRSLL 618

  Fly   643 LDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQ----------------------YT 685
            .||:|.:  .|:.|.:..|.|:||:.|::.|   ||....|                      :|
Zfish   619 HDGKLFL--IENTKQQEVYLFLFDEFLLITK---IKRNKKQKSGVVDFAAGQELELLLQEGCSFT 678

  Fly   686 YRDS---------HNLADYRVEQS---------HSRRTIGRDTRFKYQLLLARKSGKTAFTLYLK 732
            ..|.         .|:.......|         |..|         ||..:|      .|.|..:
Zfish   679 VLDQPISLDRLQLKNIDQLNATASTLPNSFIIMHQNR---------YQQCIA------VFVLQAQ 728

  Fly   733 SEHERDKWRKALTEAMESL 751
            ||..:..|...:.:|:.||
Zfish   729 SESTKKAWMSEIEKAVSSL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	6/20 (30%)
		RhoGEF	428..603	CDD:279015	58/194 (30%)
		PH_Vav	624..753	CDD:269930	37/173 (21%)
		PH	641..749	CDD:278594	31/147 (21%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
plekhg7	NP_001315140.1	DUF4675	122..>245	CDD:292348	27/136 (20%)
		RhoGEF	375..538	CDD:279015	51/172 (30%)
		PH_PLEKHG7	616..741	CDD:270065	30/144 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910