DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and arhgef12a

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_009290006.1 Gene:arhgef12a / 562455 ZFINID:ZDB-GENE-121017-3 Length:1357 Species:Danio rerio


Alignment Length:600 Identity:131/600 - (21%)
Similarity:229/600 - (38%) Gaps:116/600 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 LDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRL-VSTSSSSSSLLVSE 326
            ||.|.|...|.|....|       |.|....|...|..:.|      ||| .|.||..|.||.|.
Zfish   564 LDSVPSGRVGDSIKQRP-------QKQMSQPALGGSELIDA------GRLRGSQSSEGSDLLHSP 615

  Fly   327 SQRLQRAAAAVYNYRSSMASTEHEYAY------------IYSEDD-EKVYEDLCYVTF------- 371
            ........:|.|:..|..:..:.|:..            :.|.|. :.:|....|:.:       
Zfish   616 GLITSSPFSAPYSSPSDPSGRDSEFNMSPSAVVPRLSDGLQSGDPLDSIYPPCDYIPYNVDQLDE 680

  Fly   372 --QAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA---LHRTSRSQTASSTSFE-QRDYVIR 430
              .....|:|.|...:.........:.:..:||.|:..   .....|...|..|..| :|..||.
Zfish   681 DRDGDRPPDVGTPKPSRRFEDLQSEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTPHEIKRQEVIN 745

  Fly   431 ELIDTESNYLDVLTALKTKFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPN-- 491
            ||..||..::.:|..|...|...|.|.  |...:::.||..:.|::.:|.:.:|::......|  
Zfish   746 ELFYTERAHVRMLKVLDKVFYQKLNRDNILPPADIKYIFTNLEEIIQLHVRIVDQMTAICKKNET 810

  Fly   492 -------------------AKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
                               .|:|.|            .|.|||....|::.:....||:|.....
Zfish   811 SVIDHIGDELLSWFSSGEEEKIKQA------------VGTFCSNQPFALELIKSRQKKDQRFSSF 863

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
            :|:.|.:....:|||:||:...|||..||.||:|.:.|.|.. .::...:.||.|....:..::|
Zfish   864 MQEAESNRLCRRLQLKDIIPAEMQRFTKYPLLMDNIAKYTDE-SEEKDKVRRAAECCRQILNHVN 927

  Fly   603 EVKRDSDHLVIIQKVKD--SICDIHLLQNGNGSDLLQYGRLLL-------DGELHIKAHEDQKTK 658
            :..::|::.   |:::|  ...|:..|:......:.::..|.|       :|.|..|.::|:..:
Zfish   928 QSVKESENK---QRLEDYQRRLDLSSLKQSENPMISEFKNLDLTKRKMVHEGPLSWKINKDKTIE 989

  Fly   659 LRYAFVFDKILIMVK--------ALHIK----TGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTR 711
            | |..:.:.||::::        ..|.|    |.:.::.:.....|:...|      |::..|.|
Zfish   990 L-YTLLLEDILVLLQKQDERLILRCHSKNLAGTAETKHIFSPIIKLSTVLV------RSVATDNR 1047

  Fly   712 FKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHK-MEIYTFDAPTTCR 775
             .:.::...|:|...:.|..::..|:..|::.:|:..|.:     .:..|. :.:...|......
Zfish  1048 -SFFVISMSKNGAQIYELMAQTVSEQRMWQRQITQRAEVM-----NTKPHSVIPLPQHDGDRDGV 1106

  Fly   776 HCSKFLKG--RIHQG 788
            ..|||.||  ||..|
Zfish  1107 ELSKFSKGSDRISTG 1121

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 49/197 (25%)
PH_Vav 624..753 CDD:269930 26/147 (18%)
PH 641..749 CDD:278594 24/126 (19%)
C1_1 761..804 CDD:278556 9/30 (30%)
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
arhgef12aXP_009290006.1 PDZ_signaling 66..140 CDD:238492
RGS 308..524 CDD:295367
RhoGEF 743..928 CDD:279015 49/197 (25%)
PH-like 947..1083 CDD:302622 26/143 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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