Protein Alignment Vav and arhgef12a

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_009290006.1
• Gene: arhgef12a / 562455
• ZFINID: ZDB-GENE-121017-3
• Length: 1357
• Species: Danio rerio
• Alignment Length: 600
• Identity: 131/600 - (21%)
• Similarity: 229/600 - (38%)
• Gaps: 116/600 - (19%)

  Fly   263 LDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRL-VSTSSSSSSLLVSE 326
            ||.|.|...|.|....|       |.|....|...|..:.|      ||| .|.||..|.||.|.
Zfish   564 LDSVPSGRVGDSIKQRP-------QKQMSQPALGGSELIDA------GRLRGSQSSEGSDLLHSP 615

  Fly   327 SQRLQRAAAAVYNYRSSMASTEHEYAY------------IYSEDD-EKVYEDLCYVTF------- 371
            ........:|.|:..|..:..:.|:..            :.|.|. :.:|....|:.:
Zfish   616 GLITSSPFSAPYSSPSDPSGRDSEFNMSPSAVVPRLSDGLQSGDPLDSIYPPCDYIPYNVDQLDE 680

  Fly   372 --QAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA---LHRTSRSQTASSTSFE-QRDYVIR 430
              .....|:|.|...:.........:.:..:||.|:..   .....|...|..|..| :|..||.
Zfish   681 DRDGDRPPDVGTPKPSRRFEDLQSEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTPHEIKRQEVIN 745

  Fly   431 ELIDTESNYLDVLTALKTKFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPN-- 491
            ||..||..::.:|..|...|...|.|.  |...:::.||..:.|::.:|.:.:|::......|
Zfish   746 ELFYTERAHVRMLKVLDKVFYQKLNRDNILPPADIKYIFTNLEEIIQLHVRIVDQMTAICKKNET 810

  Fly   492 -------------------AKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
                               .|:|.|            .|.|||....|::.:....||:|.....
Zfish   811 SVIDHIGDELLSWFSSGEEEKIKQA------------VGTFCSNQPFALELIKSRQKKDQRFSSF 863

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
            :|:.|.:....:|||:||:...|||..||.||:|.:.|.|.. .::...:.||.|....:..::|
Zfish   864 MQEAESNRLCRRLQLKDIIPAEMQRFTKYPLLMDNIAKYTDE-SEEKDKVRRAAECCRQILNHVN 927

  Fly   603 EVKRDSDHLVIIQKVKD--SICDIHLLQNGNGSDLLQYGRLLL-------DGELHIKAHEDQKTK 658
            :..::|::.   |:::|  ...|:..|:......:.::..|.|       :|.|..|.::|:..:
Zfish   928 QSVKESENK---QRLEDYQRRLDLSSLKQSENPMISEFKNLDLTKRKMVHEGPLSWKINKDKTIE 989

  Fly   659 LRYAFVFDKILIMVK--------ALHIK----TGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTR 711
            | |..:.:.||::::        ..|.|    |.:.::.:.....|:...|      |::..|.|
Zfish   990 L-YTLLLEDILVLLQKQDERLILRCHSKNLAGTAETKHIFSPIIKLSTVLV------RSVATDNR 1047

  Fly   712 FKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHK-MEIYTFDAPTTCR 775
             .:.::...|:|...:.|..::..|:..|::.:|:..|.:     .:..|. :.:...|......
Zfish  1048 -SFFVISMSKNGAQIYELMAQTVSEQRMWQRQITQRAEVM-----NTKPHSVIPLPQHDGDRDGV 1106

  Fly   776 HCSKFLKG--RIHQG 788
            ..|||.||  ||..|
Zfish  1107 ELSKFSKGSDRISTG 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	49/197 (25%)
		PH_Vav	624..753	CDD:269930	26/147 (18%)
		PH	641..749	CDD:278594	24/126 (19%)
		C1_1	761..804	CDD:278556	9/30 (30%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
arhgef12a	XP_009290006.1	PDZ_signaling	66..140	CDD:238492
		RGS	308..524	CDD:295367
		RhoGEF	743..928	CDD:279015	49/197 (25%)
		PH-like	947..1083	CDD:302622	26/143 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910