DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and arhgef2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021328624.1	Gene:	arhgef2 / 561276	ZFINID:	ZDB-GENE-030717-1	Length:	872	Species:	Danio rerio

Alignment Length:	907	Identity:	190/907 - (20%)
Similarity:	341/907 - (37%)	Gaps:	217/907 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
            |.:....||..:.|...|:..|...|....:|:..||::.....           |..||
Zfish    20 NAKNKEKERMKAREKETKERESRYSNGHLFTSLSVSATTLCSAC-----------NKSIT----- 68

  Fly   214 EDIDDYIEDSLS-NMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
                  .:::|| ..|:.||.|...|.      |::|  :.:::....|||        |.:
Zfish    69 ------AKEALSCPTCNVTIHNRCRDT------LANC--AKMKQKQQRLAL--------GRN--- 108

  Fly   278 TPTPESYARQSQSPLAAAAPSVPVSAAP-------GPPMGR-------LVSTSSSSSSLLVSESQ 328
            |.|..:.|.:|::|:....||..:..:.       |...||       .|||::.:.||......
Zfish   109 TATLHNVALRSKNPILKERPSSAIYPSETLRQSFLGSRKGRSSLSLNKSVSTNNIAGSLNDDSPI 173

  Fly   329 RLQRA---AAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTG 390
            .|:|.   :....|:|:...|.|       |.:||                           |..
Zfish   174 GLRRILSHSTDSLNFRNRAMSME-------SLNDE---------------------------GET 204

  Fly   391 YDHTNTKEEEVYQDLCALHRTSRSQTASSTSFE--------------QRDYVIRELIDTESNYLD 441
            | :|:..||        |.|..:...|.|.|..              :|..||.|||.||.|::.
Zfish   205 Y-YTSMMEE--------LERDGKDFAADSWSLAVDSSYLQSQRKDVIKRQDVIYELIQTEFNHVR 260

  Fly   442 VLTALKTKF-MGPLER-HLNQDELRLIFPRIRELVDIHTKFLDKLRE----SLTPNAK-----VK 495
            .|..::..| .|.||. .:....:..|||.:.:|:.|||.||.:|.:    ||..|:.     .|
Zfish   261 TLRIMEGVFRRGMLEEVMMEMGVVHAIFPCLDQLLLIHTNFLSQLLQRRSNSLASNSNRNFTIQK 325

  Fly   496 MAQVFL---------DFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQ 551
            :..:.:         |.|:   .|.||||..|.|:....::..:::...|.:::..|...:.:..
Zfish   326 LGDILVEQFSGQNAEDMRK---CYVEFCSRHLKAVKLYKELLARDKRFQQFIRRVSRGSLLRRHG 387

  Fly   552 LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERA----KEAMIDVSQYINEVKRDSDHLV 612
            :::.:.:..|||.||.:|:.:::..|....::.:||.::    :|.:..|.|.:.|::| :..|.
Zfish   388 VQECILLVTQRITKYPVLMQRILDNTKGNEEESKSLAQSLTLIRELLCSVDQQVQELER-AQRLQ 451

  Fly   613 IIQKVKDSICDIHLLQNG--NGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKAL 675
            .||...|...:..:...|  :|::||:.| |:.:|.|..|..:..:.|..:..:...:|:.
Zfish   452 EIQSRLDPRAETKVKGGGVFHGAELLRRG-LIHEGALLWKTAQGSRLKDVHVLLMTDVLVF---- 511

  Fly   676 HIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW 740
             ::..|.:|.: .:.:.......|:...|.|....|..:  |::..:....:.|:..|:.:|:.|
Zfish   512 -MQEKDQKYVF-PTLDKPSVLCLQNLIVRDIANQQRGMF--LISHSTPPEMYELHAASKDDRNTW 572

  Fly   741 RKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYR--CKVCQ--ISVHKG 801
            .|.:.:.:.:     |.|.:....|.|.|.....|     |:..|.|..|  .::.|  :::...
Zfish   573 MKIIQQTVSN-----CPSREDFPLIETEDKALLRR-----LRADIQQKDREVLELLQERVTLFSD 627

  Fly   802 CISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENR------RIGTYLLR---VR 857
            .:.:||  .|| |:||       .:..|.|..:......|.:|.|.      |:...||.   .|
Zfish   628 LVEATG--GQN-VTVP-------TNSRNIFRADTPYAPQAEKLLNEAIVEVDRLSDVLLSSCIER 682

  Fly   858 PQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGEN 922
            ||.                      .::|    |::....|:|:...|..:.:...|:.|.....
Zfish   683 PQS----------------------CRLN----GEATEVQLTSKTADKERISVNGTYDTNGPSNK 721

  Fly   923 FAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQ-LRTD--CQVLVIGKDGDSKGWWRGKIGD 981
            ....||.|.....|.:...|.:...:..|.|.. :|.|  .:|.:..:...:.|...|.:||
Zfish   722 DRNGNQLLDKLLNEEVCQRLVNLSTQLHSIQAAVIRQDSFLEVYMQKESSPTTGTPAGSVGD 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	50/198 (25%)
		PH_Vav	624..753	CDD:269930	23/130 (18%)
		PH	641..749	CDD:278594	18/107 (17%)
		C1_1	761..804	CDD:278556	9/46 (20%)
		SH2_Vav_family	824..934	CDD:198193	21/118 (18%)
		SH3	940..993	CDD:302595	10/45 (22%)
arhgef2	XP_021328624.1	C1	47..92	CDD:237996	14/72 (19%)
		RhoGEF	244..438	CDD:238091	49/196 (25%)
		PH-like	478..595	CDD:327399	22/130 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910