Protein Alignment Vav and mcf2b

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_009303604.2
• Gene: mcf2b / 559907
• ZFINID: ZDB-GENE-091118-4
• Length: 1046
• Species: Danio rerio
• Alignment Length: 681
• Identity: 140/681 - (20%)
• Similarity: 238/681 - (34%)
• Gaps: 228/681 - (33%)

  Fly   395 NTKEEEVYQDLCALHRTSRSQTASSTSF---------EQRDYVIRELIDTESNYLDVLTALKTKF 450
            |||:.||..|.        .:..|..|:         :.:..|::|||:||..|::.|.::...:
Zfish   478 NTKKIEVMHDY--------EENRSCLSYGPEGVENPDQHKRRVMKELIETERIYVEELMSVLLGY 534

  Fly   451 MGPLE------------RHLNQDELRLIFPRIRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFL 501
            ...::            |:..:|    :|..:.|:...|:: ||..|...| ||.   ::...||
Zfish   535 RAEMDNPALSNILPSVLRNKKED----LFGNLPEIYKFHSRIFLQDLESCLETPE---RVGARFL 592

  Fly   502 DFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKY 566
            :.:|.|.:|..:|.....: |.|...|..:..|.:...|.:.     ||.|...|..|:||:.||
Zfish   593 ERKEHFQVYERYCQNKPRS-DALWRQCSDSAFIQECKGKLDH-----KLGLDSYLLKPVQRLTKY 651

  Fly   567 HLLLDKLVKETSPLHDDYRS-LERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNG 630
            .|||.:|:|.:|  :..|.| |:.|..||:|:.:.:|    ||.|.:.|              .|
Zfish   652 QLLLKELLKHSS--NSQYASELQGALNAMLDLLKSVN----DSMHQISI--------------TG 696

  Fly   631 NGSDLLQYGRLLLDGELHIKA-HEDQKTKL----------RYAFVFDKILIMVKALHIKTGDMQY 684
            ...:|...||:|:.|..::.. |:...|::          |:.|:.::.|:..|... :||
Zfish   697 YEGELSDLGRVLMQGSFNVWINHKKGPTRMKDMARFKPMQRHLFLHERALLFCKKRE-ETG---- 756

  Fly   685 TYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR-------KSGKTAFTLYLKSEHE------ 736
                          :.|.|..   ...||:.|:::.       |.....|.::...:.|
Zfish   757 --------------EGHDRTA---SYSFKHCLMMSAVGITENVKGDVKKFEIWYNGKEEVYVVQA 804

  Fly   737 -----RDKW----RKALT------------EAMESLEPPGCQSTDHKMEIYTFDAP--TTCRHCS 778
                 :..|    ||.|.            :..:.|.||...|..|......:.|.  |.|..|.
Zfish   805 PTVDVKIAWLTEIRKILNNQQKTVKGDSQPDGEQPLSPPLADSVRHISVCMPWSATQITGCSGCF 869

  Fly   779 KFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHR 843
            ..|....|||     ..:|..:   :.:||.  :||...|.:.                 :...|
Zfish   870 DVLPHSKHQG-----ASVSSEE---ADSGRV--SPVLTDPVII-----------------SPRPR 907

  Fly   844 LENRRIGTYLLRVRPQGPSTAHETMYALSLK---TD----------DNV----------IKHMKI 885
            ..|||          ..|.|:|.......|:   ||          |:|          :.|:|.
Zfish   908 NHNRR----------SWPGTSHSVDICEGLEDWTTDLSNISDSDEEDDVLLVPGRYRAMLDHLKC 962

  Fly   886 NQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAG 950
            .::   |.::.|       ..::.:        |.|:..||     |..|.:         .:.|
Zfish   963 GKD---DVIIKC-------GDVIHV--------LQESVMGL-----WHVKNL---------TRGG 995

  Fly   951 SNQLQLRTDCQVLVIGKDGDSKGWWRGKIGD 981
            ..:|.:  |..:.::|..|.|.....|..|:
Zfish   996 EGKLPV--DTLLRMLGDAGRSPSIQSGGAGN 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050
		RhoGEF	428..602	CDD:459876	52/188 (28%)
		PH_Vav	624..753	CDD:269930	27/173 (16%)
		C1_VAV	759..810	CDD:410360	12/52 (23%)
		SH2_Vav_family	824..934	CDD:198193	21/132 (16%)
		SH3	940..993	CDD:473055	8/42 (19%)
mcf2b	XP_009303604.2	None