DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and LOC559907

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009303604.1	Gene:	LOC559907 / 559907	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	677	Identity:	142/677 - (20%)
Similarity:	237/677 - (35%)	Gaps:	220/677 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 NTKEEEVYQDLCALHRTSRSQTASSTSF---------EQRDYVIRELIDTESNYLD----VLTAL 446
            |||:.||..|.        .:..|..|:         :.:..|::|||:||..|::    ||...
Zfish   478 NTKKIEVMHDY--------EENRSCLSYGPEGVENPDQHKRRVMKELIETERIYVEELMSVLLGY 534

  Fly   447 KTKFMGPLERHLNQDELRL----IFPRIRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFLDFRE 505
            :.:...|...::....||.    :|..:.|:...|:: ||..|...| ||.   ::...||:.:|
Zfish   535 RAEMDNPALSNILPSVLRNKKEDLFGNLPEIYKFHSRIFLQDLESCLETPE---RVGARFLERKE 596

  Fly   506 PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLL 570
            .|.:|..:|.....: |.|...|..:..|.:...|.:.     ||.|...|..|:||:.||.|||
Zfish   597 HFQVYERYCQNKPRS-DALWRQCSDSAFIQECKGKLDH-----KLGLDSYLLKPVQRLTKYQLLL 655

  Fly   571 DKLVKETSPLHDDYRS-LERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSD 634
            .:|:|.:|  :..|.| |:.|..||:|:.:.:|    ||.|.:.|              .|...:
Zfish   656 KELLKHSS--NSQYASELQGALNAMLDLLKSVN----DSMHQISI--------------TGYEGE 700

  Fly   635 LLQYGRLLLDGELHIKA-HEDQKTKL----------RYAFVFDKILIMVKALHIKTGDMQYTYRD 688
            |...||:|:.|..::.. |:...|::          |:.|:.::.|:..|... :||
Zfish   701 LSDLGRVLMQGSFNVWINHKKGPTRMKDMARFKPMQRHLFLHERALLFCKKRE-ETG-------- 756

  Fly   689 SHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR-------KSGKTAFTLYLKSEHE---------- 736
                      :.|.|..   ...||:.|:::.       |.....|.::...:.|
Zfish   757 ----------EGHDRTA---SYSFKHCLMMSAVGITENVKGDVKKFEIWYNGKEEVYVVQAPTVD 808

  Fly   737 -RDKW----RKALTEAMES------------LEPPGCQSTDHKMEIYTFDAP--TTCRHCSKFLK 782
             :..|    ||.|....::            |.||...|..|......:.|.  |.|..|...|.
Zfish   809 VKIAWLTEIRKILNNQQKTVKGDSQPDREQPLSPPLADSVRHISVCMPWSATQITGCSGCFDVLP 873

  Fly   783 GRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENR 847
            ...|||     ..:|..:   :.:||.  :||...|.:.                 :...|..||
Zfish   874 HSKHQG-----ASVSSEE---ADSGRV--SPVLTDPVII-----------------SPRPRNHNR 911

  Fly   848 RIGTYLLRVRPQGPSTAHETMYALSLK---TD----------DNV----------IKHMKINQEN 889
            |          ..|.|:|.......|:   ||          |:|          :.|:|..::
Zfish   912 R----------SWPGTSHSVDICEGLEDWTTDLSNISDSDEEDDVLLVPGRYRAMLDHLKCGKD- 965

  Fly   890 SGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQL 954
              |.::.|       ..::.:        |.|:..||     |..|.:         .:.|..:|
Zfish   966 --DVIIKC-------GDVIHV--------LQESVMGL-----WHVKNL---------TRGGEGKL 999

  Fly   955 QLRTDCQVLVIGKDGDSKGWWRGKIGD 981
            .:  |..:.::|..|.|.....|..|:
Zfish  1000 PV--DTLLRMLGDAGRSPSIQSGGAGN 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	54/185 (29%)
		PH_Vav	624..753	CDD:269930	27/173 (16%)
		PH	641..749	CDD:278594	22/140 (16%)
		C1_1	761..804	CDD:278556	10/44 (23%)
		SH2_Vav_family	824..934	CDD:198193	21/132 (16%)
		SH3	940..993	CDD:302595	8/42 (19%)
LOC559907	XP_009303604.1	SEC14	<20..85	CDD:326643
		SPEC	119..318	CDD:321951
		SPEC	224..415	CDD:238103
		RhoGEF	509..686	CDD:238091	54/187 (29%)
		PH-like	693..824	CDD:327399	27/166 (16%)
		SH3	952..1005	CDD:327375	13/86 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910