DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and PRKD1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001316998.1	Gene:	PRKD1 / 5587	HGNCID:	9407	Length:	920	Species:	Homo sapiens

Alignment Length:	293	Identity:	67/293 - (22%)
Similarity:	106/293 - (36%)	Gaps:	92/293 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   698 EQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHK 762
            ::|.|...|||:.|...|..:.|       .::|      ||      ..|..::.|      |.
Human   241 QKSPSESFIGREKRSNSQSYIGR-------PIHL------DK------ILMSKVKVP------HT 280

  Fly   763 MEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI-----SSTGRCKQNPVSVPPPV-- 820
            ..|:::..||.|::|.|.|||...||.:||.|:.:.||.|.     :..|....|...:.|..
Human   281 FVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAES 345

  Fly   821 -------CDRQLSEFNWFAGNM---------DRETAAHRLENRRIGTYLLRVRPQGPSTAHE-TM 868
                   .|...||.|  :|.|         |.|.|....:|.       ....|.|...|| ..
Human   346 DVVMEEGSDDNDSERN--SGLMDDMEEAMVQDAEMAMAECQND-------SGEMQDPDPDHEDAN 401

  Fly   869 YALSLKTDDNV--------IKHMK-----INQE------NSGDSMLYCLSSRRHFKTIVELVSYY 914
            ..:|..|.:|:        :||.|     :.:|      .|.|:    |..|.:::...:.::.:
Human   402 RTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDT----LRKRHYWRLDSKCITLF 462

  Fly   915 ERNDLGENFAGLNQSLQWPYKEVIATALYDYEP 947
            : ||.|..:          |||:..:.:...||
Human   463 Q-NDTGSRY----------YKEIPLSEILSLEP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	12/54 (22%)
		PH	641..749	CDD:278594	11/50 (22%)
		C1_1	761..804	CDD:278556	18/47 (38%)
		SH2_Vav_family	824..934	CDD:198193	27/138 (20%)
		SH3	940..993	CDD:302595	2/8 (25%)
PRKD1	NP_001316998.1	C1_1	147..196	CDD:278556
		C1	279..328	CDD:237996	18/48 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..410		7/31 (23%)
		PH_PKD	424..551	CDD:269945	14/76 (18%)
		STKc_PKD	587..846	CDD:270984
		S_TKc	595..847	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910