DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and PRKCH

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_006246.2	Gene:	PRKCH / 5583	HGNCID:	9403	Length:	683	Species:	Homo sapiens

Alignment Length:	312	Identity:	61/312 - (19%)
Similarity:	97/312 - (31%)	Gaps:	108/312 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTG-RCKQNPVSVPPPVCDRQ 824
            ||..|:.:..||.|.||...|.|.:.||.:||:|:::||..|.::.. .|..|.|.:...:....
Human   246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMG 310

  Fly   825 L-------------------------SEFNWFAGNMDRETAAHRLENRRI---GTY----LLRVR 857
            |                         .|.|....|..........|..|:   |::    |.||:
Human   311 LQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVK 375

  Fly   858 PQGPSTAHETMYALSLKTDDNVIK-------------------HMKINQ---------------- 887
            ..|      .:||:.:...|.:::                   |..:.|
Human   376 ETG------DLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVME 434

  Fly   888 -ENSGDSMLYCLSSRR--------HFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALY 943
             .|.||.|.:...|||        :...|:..:.:.  :|.|..:..|.          :...|.
Human   435 FVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL--HDKGIIYRDLK----------LDNVLL 487

  Fly   944 DYEPKAGSNQLQLRTDCQVLVIG--KDGDSKGWWRGKIGDTVGYFPKEYVQE 993
            |:|           ..|::...|  |:|...|........|..|...|.:||
Human   488 DHE-----------GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	18/42 (43%)
		SH2_Vav_family	824..934	CDD:198193	27/185 (15%)
		SH3	940..993	CDD:302595	11/54 (20%)
PRKCH	NP_006246.2	C2_PKC_epsilon	8..140	CDD:175981
		C1_1	172..225	CDD:278556
		C1_1	246..298	CDD:278556	19/51 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..342		2/21 (10%)
		S_TKc	355..614	CDD:214567	36/203 (18%)
		STKc_nPKC_eta	359..681	CDD:270742	35/199 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910