DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and arhgef1b

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021322373.1	Gene:	arhgef1b / 557983	ZFINID:	ZDB-GENE-060616-136	Length:	1082	Species:	Danio rerio

Alignment Length:	642	Identity:	134/642 - (20%)
Similarity:	248/642 - (38%)	Gaps:	113/642 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 KTSSIDASASSSAEYYDRTSQSGSL---DENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAED 238
            |.|.:|..|..:.:...|.|.|.|:   ...:.||:...|.                     ..:
Zfish   297 KQSRLDFEAKQNKQPPHRVSVSDSVTPPGRKTGITVSGSTH---------------------GSE 340

  Fly   239 AGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSV--PV 301
            :..|.|:          .:|...:.|..:.|....:|...|.|.|...:..........|:  |:
Zfish   341 SSEELPI----------SVSVTPSPDFQTDTVGIINNRTDPKPASEGGEVSPVSTGGTVSICEPL 395

  Fly   302 SAAPGPP-----MGRLVSTSSSSSSLLVSESQRLQRAA---AAVYNYRSSM----ASTEHEYA-- 352
            :....||     .||....:...|..|..|.:..:|..   |.....||.:    .||.|..:
Zfish   396 AVIDVPPEDIQDSGRKKPRNVRRSESLCVERRHSRRGGSTRAKQSRSRSDVDLQSTSTSHPLSPS 460

  Fly   353 --YIYSEDDEKVYE-DLCYVTF-----QAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALH 409
              :..|.:.:|..| .|...||     |.:.:|.:..       ...|..|.:|....:   :||
Zfish   461 PQHSVSVEGDKTPEIALLTPTFVPAPQQEEIEPRLLE-------LEQDPLNWRELASSE---SLH 515

  Fly   410 RTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER--HLNQDELRLIFPRIRE 472
            :.|:.:.       :|..||.||..||..::.:|:.|:|.|..|||:  ::..:|:..||..:.:
Zfish   516 KLSKKEA-------KRQEVINELFVTEQAHVRMLSVLQTVFSRPLEKQEYMTANEVATIFSSLDD 573

  Fly   473 LVDIHTKF---LDKLRES---LTPNAKVKMAQVFLDFREPFL--IYGEFCSLLLGAIDYLADVCK 529
            ::::|..|   |.||||.   :.......:...|......:.  :...|||....|::.:....|
Zfish   574 IIEMHYVFYENLKKLREEDEYIVKTISTPLLNRFSGSEGEWFQKLTARFCSYQSWALEQIKSRQK 638

  Fly   530 KNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAM 594
            |:...:..:.:.|......:|||:||:.:.|||:.||.|||:.:.|.|... .:...:.:|.|:.
Zfish   639 KDPRFNAFILEAESKPQCRRLQLKDIIPIEMQRLTKYPLLLENIAKNTEDA-TEKEKINQAAESC 702

  Fly   595 IDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDL--------LQYGRLLLDGELHIKA 651
            ..:..::||..:..::|:|::..:..: |...|:..|  :|        |....:|.:|.|..:.
Zfish   703 RKILNHVNEEVKQMENLLILKDYQRRL-DTSGLKPSN--ELYSEYKTIDLTNRTMLFEGPLTWRV 764

  Fly   652 HEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHS---------RRTIG 707
            .:::...:....:.|.:::..|    :...|....:...|:|....:|..|         .|.:.
Zfish   765 TKEKAIDVHCVLLSDLLVLFQK----QDDKMLLKCQSKSNIAVQEGKQMLSPIIKLESVFLREVA 825

  Fly   708 RDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKME 764
            .|.:..| ::....||...:.|..:|..||..|.:|:..|::.|:.....:|  |:|
Zfish   826 TDPKALY-VIFTWDSGAQIYELVAQSVGERKNWTEAIKSAVDELKKASKSNT--KLE 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/184 (26%)
		PH_Vav	624..753	CDD:269930	27/145 (19%)
		PH	641..749	CDD:278594	22/116 (19%)
		C1_1	761..804	CDD:278556	2/4 (50%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
arhgef1b	XP_021322373.1	RGS_p115RhoGEF	74..266	CDD:188709
		RhoGEF	524..710	CDD:238091	49/186 (26%)
		PH_p115RhoGEF	744..868	CDD:275429	23/128 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910