DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and PRKCB

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_002729.2	Gene:	PRKCB / 5579	HGNCID:	9395	Length:	673	Species:	Homo sapiens

Alignment Length:	301	Identity:	61/301 - (20%)
Similarity:	108/301 - (35%)	Gaps:	95/301 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQL 825
            ||.:|:|:.:||.|.||...|.|.||||.:|..|.::|||.|:.:.           |.:|....
Human   102 HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNV-----------PSLCGTDH 155

  Fly   826 SEFN---WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKIN- 886
            :|..   :...::||:.....:.:.:      .:.|..|:...:....|.|..|.......|..
Human   156 TERRGRIYIQAHIDRDVLIVLVRDAK------NLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKT 214

  Fly   887 -----------------QENSGDSML------YCLSSRRHF------------KTIVE----LVS 912
                             :|:..|..|      :.|:||..|            |..|:    |:|
Human   215 IKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLS 279

  Fly   913 YYE---------------RNDLGENF--AGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDC 960
            ..|               ..:|.:.|  |.::|..:.| :|.....:..::.....::::|....
Human   280 QEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVP-EEKTTNTVSKFDNNGNRDRMKLTDFN 343

  Fly   961 QVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQKLASEEL 1001
            .::|:||                |.|.|..:.|:| .::||
Human   344 FLMVLGK----------------GSFGKVMLSERK-GTDEL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	21/42 (50%)
		SH2_Vav_family	824..934	CDD:198193	25/169 (15%)
		SH3	940..993	CDD:302595	7/52 (13%)
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386	23/63 (37%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	20/135 (15%)
		STKc_cPKC_beta	341..663	CDD:270767	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910