DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and prkd1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_005158873.1	Gene:	prkd1 / 557123	ZFINID:	ZDB-GENE-080131-1	Length:	886	Species:	Danio rerio

Alignment Length:	283	Identity:	63/283 - (22%)
Similarity:	101/283 - (35%)	Gaps:	87/283 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI-----SSTGRCKQN-PVSVPPP 819
            |...|:::..||.|:||.|.|||...||.:||.|:.:.||.|.     :..|...:| .:..|..
Zfish   245 HTFVIHSYTRPTVCQHCKKLLKGLFRQGLQCKDCKFNCHKRCAPKVPNNCLGEVSRNGDLLSPGA 309

  Fly   820 VCDRQLSEFNWFAGNMDRETAAHR-----LENRRIG---TYLLRVRPQGPSTAH----------- 865
            ..|..:.|     |..|.:...|.     :|...:|   .||        ...|
Zfish   310 ESDVVMEE-----GCDDHDGDRHSPLIDDMEESLVGDSAAYL--------EAGHGELGDFQDLDP 361

  Fly   866 -ETMYALSLKTDDNV--------IKHMKINQEN-----------SGDSMLYCLSSRRHFKTIVEL 910
             |:...:|..|.:|:        :||.|....|           |.|:    |..|.:::...:.
Zfish   362 DESNRIISPSTSNNIPLMRVVQSVKHTKRKSSNVMKEGWLVHFTSKDT----LRKRHYWRLDSKC 422

  Fly   911 VSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQL---------QLRTDCQVLVIG 966
            ::.:: ||.|..:          |||:..:.:...||....|.|         ::.|...|..:|
Zfish   423 ITLFQ-NDTGSKY----------YKEIPLSEVLSLEPAKTFNLLPEGANPHCFEIATTSLVYYVG 476

  Fly   967 K-----DGDSKGWWRGKIGDTVG 984
            :     ||.|.|:....:...||
Zfish   477 ENLSRADGGSSGYGSSMLVSGVG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	19/47 (40%)
		SH2_Vav_family	824..934	CDD:198193	24/148 (16%)
		SH3	940..993	CDD:302595	13/59 (22%)
prkd1	XP_005158873.1	C1_1	114..163	CDD:278556
		C1	245..294	CDD:237996	19/48 (40%)
		PH_PKD	388..517	CDD:269945	25/127 (20%)
		STKc_PKD	553..812	CDD:270984
		S_TKc	561..813	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910