Protein Alignment Vav and vav2

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_021324720.1
• Gene: vav2 / 556413
• ZFINID: ZDB-GENE-091204-420
• Length: 891
• Species: Danio rerio
• Alignment Length: 1114
• Identity: 273/1114 - (24%)
• Similarity: 456/1114 - (40%)
• Gaps: 369/1114 - (33%)

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            ||:|..||..|||:||:|:...|.|.:..||..||||||||.::.:|.|.|:|.::.|.:|||:|
Zfish     4 WRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQMLHNLSPGSVDLKQINFRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||.|||:.||:|:::||:|..|:|:.:|.:|:..||::|. ..:.|:.      .:
Zfish    69 FLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISALSRISH-NSIAQIK------GI 126

  Fly   151 QLSPTE-RSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTE 214
            :..|:| .:.:::.:|:.|.                              .|.:..|:    |.:
Zfish   127 RPFPSEDTALNEDDVYRSLE------------------------------ELADEHDV----GED 157

  Fly   215 DIDDYIEDSLSNMCDSTIDNDAED---AGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNA 276
            ||.|.:.      |:...|:..||   ..|..|::|:
Zfish   158 DIYDCVP------CEDDGDDIYEDIIKVEVRQPMVSE---------------------------- 188

  Fly   277 VTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYR 341
                                          ||.||                       .::..|.
Zfish   189 ------------------------------PPYGR-----------------------RSLIRYM 200

  Fly   342 SSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLC 406
            ..|..|         |||::   :.|.|
Zfish   201 QKMGMT---------EDDKR---NCCLV------------------------------------- 216

  Fly   407 ALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIR 471
                                    |:.:||:.|...|..::..:|.||::.|...|:..||..:.
Zfish   217 ------------------------EIQETEAKYYKTLEDIEKNYMIPLKQVLTPQEMEAIFVNLE 257

  Fly   472 ELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
            :::.:|...|..:..::..... .:.::||||:|..||||::||.:..|...|.::....:.:..
Zfish   258 DIIRVHFALLRAIDLTMVSGGN-GLGKIFLDFKERLLIYGQYCSHMENAQKTLDELIATREDVKC 321

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYI 601
            .|::|......||.:|:|:|.|||||:|||||||.:||..:.. ..:.:.|:.|.|||.|::.||
Zfish   322 KVEECTMKVQEGKFKLQDLLVVPMQRVLKYHLLLKELVSHSMD-RPERQQLKEALEAMQDLAMYI 385

  Fly   602 NEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            ||||||::.|..|.:.:.||.::.:       .|.:|||..:||||.:.:..::..:.||.|:||
Zfish   386 NEVKRDNETLKKISEFQSSIENLQV-------KLEEYGRPKIDGELKVCSIVNRTKQDRYIFLFD 443

  Fly   667 KILIMVKALHIKTGDMQYTYR-------DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGK 724
            |::|:.|    :.|   |.|.       ..:.::|..:.....:::.|:  .:.|...|....||
Zfish   444 KVVIVCK----RKG---YNYELKEVIELHLYKMSDDPMNNRDMKKSSGK--MWSYGFYLIHLQGK 499

  Fly   725 TAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGY 789
            ..|..:.|:|..:.||.:....||.:::|....:..|..:::||:..|.||.|...|:|..:|||
Zfish   500 QGFQFFCKTEDTKRKWMEQFEMAMSNIKPERATANQHNFQMHTFEKNTNCRACKMLLRGIFYQGY 564

  Fly   790 RCKVCQISVHKGCISSTGRCKQNP----------------------VSVPP---PVC-------- 821
            .|.:|....||.|:.....||.:|                      ...||   |:|
Zfish   565 YCSLCGTGAHKECLEIITICKISPHDSEPGLPQSGPKMVAIRNYHGTPAPPGKIPLCFQTGEVIE 629

  Fly   822 ------------------------------------------DRQLSE------FNWFAGNMDRE 838
                                                      :||.|.      :.||||||:|:
Zfish   630 LLKGDPDTSWWEGKLIQTQKTGYFPSSSVKPCLDPKPFQAFSNRQSSRETDYYVYPWFAGNMERQ 694

  Fly   839 TAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRH 903
            .|.:.|::...||||:|.|     ||....:|:|:|.:|.| ||:|:.::   |:.:: ::..:.
Zfish   695 QADNLLKSHSSGTYLIRER-----TAEAERFAISIKFNDEV-KHIKVIEK---DNWIH-ITEAKK 749

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYK--------------------------------- 935
            |::::|||.||:.:.|.|:|..|:.:|::|||
Zfish   750 FESLLELVEYYQSHSLKESFKLLDTTLRYPYKSRERSSSRTNTRSPAATCASYNFSFLSPQGLNF 814

  Fly   936 --------------EVIATALYDYEPKA-GSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGY 985
                          .|::||:..|...| ...:|.||....|.:..|.|..:|||:|:....:|:
Zfish   815 SSQSSAPFWSVFTPRVVSTAVARYNFAARDMRELSLREGDIVKIYSKIGGDQGWWKGEANGRIGW 879

  Fly   986 FPKEYVQEQ 994
            ||..||.|:
Zfish   880 FPSTYVDEE 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	55/110 (50%)
		RhoGEF	428..603	CDD:279015	56/174 (32%)
		PH_Vav	624..753	CDD:269930	32/135 (24%)
		PH	641..749	CDD:278594	27/114 (24%)
		C1_1	761..804	CDD:278556	17/42 (40%)
		SH2_Vav_family	824..934	CDD:198193	39/115 (34%)
		SH3	940..993	CDD:302595	19/53 (36%)
vav2	XP_021324720.1	CAMSAP_CH	18..103	CDD:314792	43/84 (51%)
		RhoGEF	211..386	CDD:238091	57/240 (24%)
		PH_Vav	401..528	CDD:269930	34/142 (24%)
		C1	536..579	CDD:237996	17/42 (40%)
		SH3	601..660	CDD:327375	4/58 (7%)
		SH2_Vav2	680..782	CDD:198269	39/111 (35%)
		SH3_VAV2_2	832..889	CDD:212910	20/57 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6022
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1770
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm25576
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	O	PTHR45818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870