DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and arhgef7a

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021334338.1	Gene:	arhgef7a / 553493	ZFINID:	ZDB-GENE-060322-11	Length:	864	Species:	Danio rerio

Alignment Length:	1031	Identity:	193/1031 - (18%)
Similarity:	334/1031 - (32%)	Gaps:	328/1031 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL-----DPREFNRKP 81
            :.|.||....|: .|....:.||.   .|..:|:|||:||.|:..|.|.:.     ||:..:.
Zfish     6 QTVTWLITLGVLESPKKTISDPDG---FLQASLKDGVVLCRLLERLRPGTTDKIIQDPKNDSE-- 65

  Fly    82 QMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDL- 145
                  |..||..||..|    .:...:.||...|....|..|||.||..|:      ::..|:
Zfish    66 ------CLSNITEFLKGC----AVFRVEPFEAGDLLQGHNISRVLTTLVALN------KVTADIG 114

  Fly   146 IGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIE 210
            ||            ||....:  ||   :..:..|.::.||.|           ||..:|.:
Zfish   115 IG------------SDSVCTR--HS---SAHRIKSFESLASQS-----------SLGRSSKL--- 148

  Fly   211 NGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT----- 270
                 :.:.....:||:.|.|   |..:|.:......:.|.::..||:|... |::|.|.
Zfish   149 -----LHNQFRSLVSNIGDMT---DNSNAQLVVKARFNFQQTNEDELTFSKG-DLISVTRTEEGG 204

  Fly   271 --DGASNAVTP-TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQR 332
              :|..|..|. .|.:|.::.:                    |.....|..|.:|
Zfish   205 WWEGILNGKTGWFPSNYVKEVK--------------------GSDKQVSPKSGNL---------- 239

  Fly   333 AAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTK 397
                                                     |:.|:           |:|
Zfish   240 -----------------------------------------KSPPK-----------GFD----- 247

  Fly   398 EEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLE--RHLNQ 460
                               .:|.|....:.|::.:::||:.|...|..|.|.::.||:  ..|:.
Zfish   248 -------------------TASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSP 293

  Fly   461 DELRLIFPRIRELVDIHTKFLDKLRESLT--PNAKVKMAQVFLDFREPF-LIYGEFCSLLLGAID 522
            .::.:|...:.|:.......:..| |.||  |..:.|:...||:..... .:...:||.....::
Zfish   294 ADVSVILGNLEEISTFQQTLVQSL-EDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPSTVN 357

  Fly   523 YLADVCKKNQIIDQLVQKCERDYNV-GKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRS 586
            .|.   ..::.:.:.::  .|..:| |.|.|...||.|..|:.:|..||.:|.:.....|.|...
Zfish   358 VLT---VHSEELGEFME--ARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTE 417

  Fly   587 LERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIK 650
            :::...|..::|....|| ||....|.|:.:.      |.|.:   |.|:...|.:|...:..::
Zfish   418 IQKCMTAFKNLSAQCQEVRKRKELELQILAET------IRLWE---GEDIKTLGSVLYMSQAMVQ 473

  Fly   651 AHEDQKTKLRYAFVFDKILIMVKALHIKTG------------------DMQYTYRDSHNLAD--- 694
            .|..::...||..:|..:|:::.|....:|                  |.: :::|:..|:.
Zfish   474 NHGCEEKNERYLLLFPHVLLILSASPRMSGFIYQGKLPLSGMTVTPLEDCE-SHKDAFELSGSMF 537

  Fly   695 -------YRVEQSHS-RRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEH----ERDKWRKALT-- 745
                   |..:..|. ...:.|.|  |:..:.|..........:....|    .|....:.||
Zfish   538 ERLQVICYNKQDLHDWLEHLNRQT--KHTTMAAPSMKPLTVPCHTLPSHPLTPSRHGESRGLTVA 600

  Fly   746 EAMESLEPPGCQSTDHKMEIY-TFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI------ 803
            .|..:|..|....|.|...:: ..:.|.|.:..|                     ..|:
Zfish   601 PAYHTLPHPSSHGTPHSTMMWGPLEPPKTQKPWS---------------------LSCLRPAPPL 644

  Fly   804 -SSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHET 867
             .|...|.:..:|..|....:.|.:........|.|.|..:                  ||
Zfish   645 RPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRK------------------ST---- 687

  Fly   868 MYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFA-------- 924
               ::|:.|..::|.::          .||.|:    ||...|.|.::..||..|..
Zfish   688 ---VALEEDAQILKVIE----------AYCTSA----KTRQTLNSTWQGTDLMHNHVLDQSSADS 735

  Fly   925 -GLNQSLQWPYKEVIATALYDYEP-------KAGSNQLQLRTDCQVLVIGKDGDSK 972
             |...|:..|......:...||:.       :.||...|.:.....|::  .||.|
Zfish   736 LGRRSSISRPEATSDLSEDSDYDSIWTAHSYRMGSVTRQWKDGSPALIV--PGDEK 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	34/114 (30%)
		RhoGEF	428..603	CDD:279015	40/180 (22%)
		PH_Vav	624..753	CDD:269930	28/163 (17%)
		PH	641..749	CDD:278594	22/142 (15%)
		C1_1	761..804	CDD:278556	5/50 (10%)
		SH2_Vav_family	824..934	CDD:198193	21/118 (18%)
		SH3	940..993	CDD:302595	9/40 (23%)
arhgef7a	XP_021334338.1	CH	21..106	CDD:214479	29/99 (29%)
		RhoGEF67_u1	116..168	CDD:318756	17/90 (19%)
		SH3_alphaPIX	170..226	CDD:212993	12/56 (21%)
		RhoGEF	256..433	CDD:238091	40/182 (22%)
		PH_Cool_Pix	464..562	CDD:269932	15/100 (15%)
		RhoGEF67_u2	621..715	CDD:318755	23/153 (15%)
		betaPIX_CC	775..861	CDD:318676	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910