DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and ARHGEF38

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001229658.1	Gene:	ARHGEF38 / 54848	HGNCID:	25968	Length:	777	Species:	Homo sapiens

Alignment Length:	814	Identity:	175/814 - (21%)
Similarity:	285/814 - (35%)	Gaps:	235/814 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
            |..|.:|......|:.|...|..    ..|.|..|:        .......|.|.|||
Human    40 SSVSGDHSGTLRRSQSDRTEYNQ----KLQEKMTPQ--------GECSVAETLTPEEE------- 85

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRL--IFPRI 470
             |...|...       :|:.:|:|||.||.:||:.|.....:.:.|| |:...|.|.:  :|..|
Human    86 -HHMKRMMA-------KREKIIKELIQTEKDYLNDLELCVREVVQPL-RNKKTDRLDVDSLFSNI 141

  Fly   471 RELVDIHTKFLDKLRESLT---PNAKVKMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKN 531
            ..:..|..|.|..|.|:.|   |..:| :.:|||..:.|.. ||..:|.....|...|....|:.
Human   142 ESVHQISAKLLSLLEEATTDVEPAMQV-IGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEE 205

  Fly   532 QIIDQL---VQKCERDY-NVGKLQLRDILSV---PMQRILKYHLLLDKLVKETSPLHDDYRSLER 589
            ::.:.|   :|..::.| ..||..|.|:.|:   |:||::||.|||.:|...|.|.|.|||:|:.
Human   206 ELKEHLSHCIQSLKKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDD 270

  Fly   590 AKEAMIDVSQYINEVKRDSDHLVIIQKVKD---------SICDIHLLQNGNGSDLLQYGRLLLDG 645
            |..|:.|::..|||:||..| ||:..|..|         |..:||.:.. ....:..:.::|..|
Human   271 AFAAVKDINVNINELKRRKD-LVLKYKKNDEDESLKDKLSKLNIHSISK-KSKRVTNHLKILTRG 333

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKAL-----HI--------------------KTGDMQYT 685
            |..:|.:...:.:..:..:...:.:.||.:     ||                    |..:|.|:
Human   334 ESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYNKDDEMDYS 398

  Fly   686 YRDSHNLADYRVEQSHSRRTI--------------GRDTRFKYQLLLARKSGKTAFTLYL-KSEH 735
            ...|:.|.......||.:|.|              .:..:.:|..||...|       || :|..
Human   399 ETLSNALNSCHDFASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNS-------YLQRSTG 456

  Fly   736 ERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPT-----TCRHCS-----KFLKGRIHQGY- 789
            |.....|...||:.:      |..:   |:..|:...     .|. ||     :.|.....|.|
Human   457 EESDLAKKEYEALNA------QLVE---ELQAFNQAARKILLNCL-CSFITLLRDLMLVAQQAYS 511

  Fly   790 ---------------RCKVCQISVHKGCISSTGRC---------KQNPVSVPPPVCDRQLSEFNW 830
                           :.:|.:...:..|:......         |:.||.:.|
Human   512 TLVPMPLLVSSISEIQNQVLEEIQNLNCVKENSATFIERKLSFEKKKPVQILP------------ 564

  Fly   831 FAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETM-YALSLKTDD----------------- 877
               .|..:|..||  ::.:.||......|.....:.|. |.::|...|
Human   565 ---EMPHQTDIHR--SKLLSTYSAEELYQAKRKCNATQEYDINLLEGDLVAVIEQKDPLGSTSRW 624

  Fly   878 -------------------NVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERND----- 918
                               |..|..|::.||.     :|...   |:.|...||....:|
Human   625 LVDTGNVKGYVYSSFLKPYNPAKMQKVDAENR-----FCDDD---FENISLFVSSRPASDSVTGT 681

  Fly   919 ----LGENFAGLN-------------QSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVI- 965
                :|::.:.|:             .|.| ...|.|..|::.::.:: .::|.|:...:|.::
Human   682 SESSIGDSSSSLSGTCGKFETNGTDVDSFQ-EVDEQIFYAVHAFQARS-DHELSLQEYQRVHILR 744

  Fly   966 --GKDGDSKGWWRGKIGDTVGYFPKEYVQEQKLA 997
              ...| :|.||..:.....||.|..|:.:...|
Human   745 FCDLSG-NKEWWLAEAQGQKGYVPANYLGKMTYA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	62/187 (33%)
		PH_Vav	624..753	CDD:269930	30/168 (18%)
		PH	641..749	CDD:278594	28/147 (19%)
		C1_1	761..804	CDD:278556	10/68 (15%)
		SH2_Vav_family	824..934	CDD:198193	26/168 (15%)
		SH3	940..993	CDD:302595	12/55 (22%)
ARHGEF38	NP_001229658.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..72		9/43 (21%)
		RhoGEF	98..284	CDD:279015	62/187 (33%)
		BAR_DNMBP	336..522	CDD:153273	34/202 (17%)
		SH3	586..642	CDD:302595	5/55 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694		2/20 (10%)
		SH3_DNMBP_C2	717..773	CDD:213017	13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910