DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Kalrn

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011244253.1	Gene:	Kalrn / 545156	MGIID:	2685385	Length:	2999	Species:	Mus musculus

Alignment Length:	1033	Identity:	193/1033 - (18%)
Similarity:	332/1033 - (32%)	Gaps:	349/1033 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SQCRKVQQLHPDLIGFNLQLSPTERSHSDEA--IYKD-LHSTDLNMRKTSSIDASASSSAEYYDR 194
            |..||.::.|..|...:|..|...:..|...  :||: |.:::|.:  |..::......|.:..|
Mouse  1496 SLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGV--TEHVEGDPCKFALWSGR 1558

  Fly   195 TSQS---------------------------------GSLDE-------------NSDITIENGT 213
            |..|                                 |:|.|             ||.   .:|.
Mouse  1559 TPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSK---RDGV 1620

  Fly   214 EDIDDYIEDS--------LSNMCDSTIDNDAEDAGVE-TPLLSDCQGSHVRELSFDL-------- 261
            ||.|...:.|        .|....:|:::|....|.| |.:|.|....|..|||..:
Mouse  1621 EDGDSQGDGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAGHSSELSIQVGQTVELLE 1685

  Fly   262 ---------------------------ALDVVSSTTDGASNAVTPTPESYARQS-----QSPLAA 294
                                       ||.:..|.:....:...|..:||:..|     :|...|
Mouse  1686 RPSERPGWCLVRTTERSPPQEGLVPSSALCISHSRSSVEMDCFFPLKDSYSHSSSENGGKSESVA 1750

  Fly   295 AAPSVP----VSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAA--------AVYNYRSSM--- 344
            ...|.|    :.::|||.     .::::....|.|..:||....|        .|.:.|.|.
Mouse  1751 HLQSQPSLNSIHSSPGPK-----RSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLG 1810

  Fly   345 --------------ASTEHEYAYIYSEDDE----------KVY------EDLCYVTFQAKAKPEV 379
                          |..:.:..:...|.||          |::      :::..:....:|.|:|
Mouse  1811 SPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPPDV 1875

  Fly   380 TT-------------DNIACNGTGY-----DHT--------------NTKEEEVYQDLCALHRTS 412
            .|             :.:...|..|     |.|              |.:||:
Mouse  1876 PTAADLVSAIEKLVKNKLTLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQ------------ 1928

  Fly   413 RSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIREL 473
                 .:.:...|.:|:.||:.||.:|:..|..:...||..:|.....:::|    ::|..|.::
Mouse  1929 -----KAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQI 1988

  Fly   474 VDIHTK-FLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFC------SLLLGAID-YLADVCKK 530
            .|.|.. ||.:|.:.:  ..:.::||:|:.......||..:|      ..::...| |..:|
Mouse  1989 YDWHKDFFLAELEKCI--QEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEV--- 2048

  Fly   531 NQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMI 595
            .|.|:|            :|.|.|.|..|:|||.||.|||...::.:.....:...:|:|.|.|.
Mouse  2049 KQEINQ------------RLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMC 2101

  Fly   596 DVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHI---KAHEDQKT 657
            .|.:..|:                 :.::..||...|: |...|:||.....::   .|....:|
Mouse  2102 LVPKRCND-----------------MMNLGRLQGFEGT-LTAQGKLLQQDTFYVIELDAGMQSRT 2148

  Fly   658 KLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSH------SRRTIGRDTRFKYQL 716
            |.|..|:|::|:|..:.|...:....|.::.|..: :|.|.:.:      ....:.|:|..:..|
Mouse  2149 KERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKM-NYLVLEDNVDGDPCKFALMNRETSERVIL 2212

  Fly   717 LLARKSGKTAFTLYLKS--EHERD----------KWRKALTEAMESLEPP--------------- 754
            ..|....:.|:...:..  |.:||          ..||..:.|:...:||
Mouse  2213 QAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVIRSQPPRVPQASPRPYSSGPV 2277

  Fly   755 ------------------------GCQSTDHKMEIYTFDAPTT-----CRHCSKFLKGRIHQGYR 790
                                    |....|:......|||...     |...|....  |...|.
Mouse  2278 GSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQNDLGGCNGTSTMTV--IKDYYA 2340

  Fly   791 CKVCQISVHKG-CISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGN----MDRETAAHRLENRRI- 849
            .|..:|.|.:| .:......:||...|..|..|...:...|..|:    :.:.|||....:..|
Mouse  2341 LKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLAKATAAAESSDGSIK 2405

  Fly   850 ---GTYLLRVRPQ------------GPSTAHETMYALSLKTDDNVIKHMKINQENSGD 892
               ..:.||:|.:            ||.           |..|.:...:.:.:.||.:
Mouse  2406 KSCSWHTLRMRKRADVENSGKNEATGPR-----------KPKDILGNKVSVKETNSSE 2452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/186 (26%)
		PH_Vav	624..753	CDD:269930	31/149 (21%)
		PH	641..749	CDD:278594	26/128 (20%)
		C1_1	761..804	CDD:278556	11/48 (23%)
		SH2_Vav_family	824..934	CDD:198193	15/89 (17%)
		SH3	940..993	CDD:302595
Kalrn	XP_011244253.1	SEC14	47..185	CDD:214706
		SPEC	198..418	CDD:238103
		SPEC	319..544	CDD:238103
		SPEC	545..774	CDD:238103
		SPEC	899..1137	CDD:238103
		SPEC	1143..1243	CDD:197544
		RhoGEF	1292..1462	CDD:238091
		PH1_Kalirin_Trio_like	1469..1591	CDD:270060	17/96 (18%)
		SH3_Kalirin_1	1657..1716	CDD:212786	10/58 (17%)
		SH3-RhoG_link	1714..1929	CDD:374666	37/236 (16%)
		RhoGEF	1939..2108	CDD:366202	48/185 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	2113..2247	CDD:270061	28/135 (21%)
		Extensin_2	2259..2311	CDD:252669	4/51 (8%)
		SH3_Kalirin_2	2331..2387	CDD:212787	13/57 (23%)
		I-set	2478..2572	CDD:369462
		FN3	2576..2667	CDD:238020
		STKc_Kalirin_C	2697..2944	CDD:271017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910