DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and Epb41l4b

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_011248370.1 Gene:Epb41l4b / 54357 MGIID:1859149 Length:902 Species:Mus musculus


Alignment Length:660 Identity:128/660 - (19%)
Similarity:209/660 - (31%) Gaps:218/660 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 PLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIY 355
            |.|||:.|| :.||||             .|:..:....|....|||: ..:|.|:....|..::
Mouse    41 PAAAASSSV-LPAAPG-------------GSVFPAGGGPLLTGGAAVH-ISASGAAKATLYCRVF 90

  Fly   356 SEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQ-DLCALHRTSRSQTASS 419
            ..|..:|..||     ...||.:...|.|                ||. ||.             
Mouse    91 LLDGTEVSVDL-----PKHAKGQDLFDQI----------------VYHLDLV------------- 121

  Fly   420 TSFEQRDYVIRELIDTE--SNYLDVLTALKTKF-MGPLERHLNQDELRLIFPRIRELVDIHTKFL 481
                :.||...:.:|:.  :::||....:|.:. :||                 ...:....|:.
Mouse   122 ----ETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGP-----------------AYALHFRVKYY 165

  Fly   482 DKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYN 546
                 |..||          :.||.|..|                         ..|.:...|..
Mouse   166 -----SSEPN----------NLREEFTRY-------------------------LFVLQLRHDIL 190

  Fly   547 VGKLQLRDILSVPMQRI-LKYHLLLDKLVKETSPLHDDYRSLERAKEAM-IDVSQYINEVKRDSD 609
            .|||:.....:|.:..: |:..|...:|.:.|..|..::|.:....||| .|:.|...|.:..|.
Mouse   191 SGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSP 255

  Fly   610 ---HLVIIQKVK---DSICDIHLLQNGNGSD----LLQYGRLLLDG------------------- 645
               .|..:.|.|   ....|:|:::..:|.:    |...|.|:.:|                   
Mouse   256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320

  Fly   646 ---ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIG 707
               .|.:...:||..:..:.|||       :....:|....:.....|: |.:|:....:.::..
Mouse   321 SKLTLVVVEDDDQGREQEHTFVF-------RLDSARTCKHLWKCAVEHH-AFFRLRTPSNSKSAR 377

  Fly   708 RD-----TRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT 767
            .|     :||::       ||:|.:    ::.|.....|.:..|...|...|   |..|.    |
Mouse   378 SDFIRLGSRFRF-------SGRTEY----QATHGSRLRRTSTFERKPSKRYP---SRRHS----T 424

  Fly   768 FDAPT---TCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFN 829
            |.|..   ..:.||| ....:|.      .|...|.....|..|.:.:..:|..|:....||   
Mouse   425 FKASNPVIAAQLCSK-ANPEVHN------YQPQYHPDVHPSQPRWRPHSPNVSYPLPSPALS--- 479

  Fly   830 WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTA----------HETMYALSLKTDDNVIKHMK 884
                  ..|.....||... ||      |..|.|:          |.:.|.|||..::   |...
Mouse   480 ------PTERLPFSLEENG-GT------PFAPKTSGRHHHQHQHQHHSNYGLSLTLEN---KEAP 528

  Fly   885 INQENSGDSM 894
            :...|:..::
Mouse   529 LRSPNASKAL 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 31/179 (17%)
PH_Vav 624..753 CDD:269930 26/159 (16%)
PH 641..749 CDD:278594 21/134 (16%)
C1_1 761..804 CDD:278556 10/45 (22%)
SH2_Vav_family 824..934 CDD:198193 17/81 (21%)
SH3 940..993 CDD:302595
Epb41l4bXP_011248370.1 B41 87..277 CDD:214604 51/284 (18%)
FERM_C_NBL4_NBL5 273..366 CDD:270007 16/100 (16%)
FA 379..419 CDD:370090 11/53 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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