DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Epb41l4b

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011248370.1	Gene:	Epb41l4b / 54357	MGIID:	1859149	Length:	902	Species:	Mus musculus

Alignment Length:	660	Identity:	128/660 - (19%)
Similarity:	209/660 - (31%)	Gaps:	218/660 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 PLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIY 355
            |.|||:.|| :.||||             .|:..:....|....|||: ..:|.|:....|..::
Mouse    41 PAAAASSSV-LPAAPG-------------GSVFPAGGGPLLTGGAAVH-ISASGAAKATLYCRVF 90

  Fly   356 SEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQ-DLCALHRTSRSQTASS 419
            ..|..:|..||     ...||.:...|.|                ||. ||.
Mouse    91 LLDGTEVSVDL-----PKHAKGQDLFDQI----------------VYHLDLV------------- 121

  Fly   420 TSFEQRDYVIRELIDTE--SNYLDVLTALKTKF-MGPLERHLNQDELRLIFPRIRELVDIHTKFL 481
                :.||...:.:|:.  :::||....:|.:. :||                 ...:....|:.
Mouse   122 ----ETDYFGLQFLDSAQVTHWLDHAKPIKKQMKVGP-----------------AYALHFRVKYY 165

  Fly   482 DKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYN 546
                 |..||          :.||.|..|                         ..|.:...|..
Mouse   166 -----SSEPN----------NLREEFTRY-------------------------LFVLQLRHDIL 190

  Fly   547 VGKLQLRDILSVPMQRI-LKYHLLLDKLVKETSPLHDDYRSLERAKEAM-IDVSQYINEVKRDSD 609
            .|||:.....:|.:..: |:..|...:|.:.|..|..::|.:....||| .|:.|...|.:..|.
Mouse   191 SGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKEYRGKSP 255

  Fly   610 ---HLVIIQKVK---DSICDIHLLQNGNGSD----LLQYGRLLLDG------------------- 645
               .|..:.|.|   ....|:|:::..:|.:    |...|.|:.:|
Mouse   256 AQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKK 320

  Fly   646 ---ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIG 707
               .|.:...:||..:..:.|||       :....:|....:.....|: |.:|:....:.::..
Mouse   321 SKLTLVVVEDDDQGREQEHTFVF-------RLDSARTCKHLWKCAVEHH-AFFRLRTPSNSKSAR 377

  Fly   708 RD-----TRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT 767
            .|     :||::       ||:|.:    ::.|.....|.:..|...|...|   |..|.    |
Mouse   378 SDFIRLGSRFRF-------SGRTEY----QATHGSRLRRTSTFERKPSKRYP---SRRHS----T 424

  Fly   768 FDAPT---TCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFN 829
            |.|..   ..:.||| ....:|.      .|...|.....|..|.:.:..:|..|:....||
Mouse   425 FKASNPVIAAQLCSK-ANPEVHN------YQPQYHPDVHPSQPRWRPHSPNVSYPLPSPALS--- 479

  Fly   830 WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTA----------HETMYALSLKTDDNVIKHMK 884
                  ..|.....||... ||      |..|.|:          |.:.|.|||..::   |...
Mouse   480 ------PTERLPFSLEENG-GT------PFAPKTSGRHHHQHQHQHHSNYGLSLTLEN---KEAP 528

  Fly   885 INQENSGDSM 894
            :...|:..::
Mouse   529 LRSPNASKAL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	31/179 (17%)
		PH_Vav	624..753	CDD:269930	26/159 (16%)
		PH	641..749	CDD:278594	21/134 (16%)
		C1_1	761..804	CDD:278556	10/45 (22%)
		SH2_Vav_family	824..934	CDD:198193	17/81 (21%)
		SH3	940..993	CDD:302595
Epb41l4b	XP_011248370.1	B41	87..277	CDD:214604	51/284 (18%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	16/100 (16%)
		FA	379..419	CDD:370090	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910