DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Arhgef5

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_598435.1	Gene:	Arhgef5 / 54324	MGIID:	1858952	Length:	1581	Species:	Mus musculus

Alignment Length:	774	Identity:	160/774 - (20%)
Similarity:	269/774 - (34%)	Gaps:	177/774 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 DLTNFHRVLITLSKLSQCRKVQQLHP----DLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKT 178
            |:..|:...|:.|.:|  |..:.|.|    |.......|.|..|..|.......:||......:.
Mouse   805 DMPEFYHPSISSSYIS--RMYRPLPPVPIIDPSSEPPPLPPKSRGRSKSIQGGVIHSGGQAKPRP 867

  Fly   179 SSIDASASSSAEYYDRTS---QSGSLDENSDITIENGTEDIDDYIEDSL--SNMCDSTIDNDAED 238
            ::.|.:||:.:  ..|||   .:|...|:..:|.....|     :...|  |||     .|....
Mouse   868 NNQDWTASTLS--VGRTSWPPATGRSTESLPLTSRCNNE-----VSPGLAFSNM-----TNLLSP 920

  Fly   239 AGVETPLLSDCQ-------------------GSHVRELSFDLALDVVSSTTDGASNAVTP----- 279
            :...||.:.|.|                   ||..|....:...:...|......|:..|
Mouse   921 SSPTTPWIPDLQRPTTKDESGLTEESEPPVRGSFRRSAPQEEFNNTRRSALGSRKNSEKPLHHQL 985

  Fly   280 --------------TPESYARQ---SQSP--------LAAAAPSV-PVSAAP--GPPMGRLVSTS 316
                          |.||.:.|   .|.|        .....||: |.|::.  .|..|||..:|
Mouse   986 EKASSWPHRRDPARTSESSSEQVVLGQVPNKQKGWNRQGLRRPSILPESSSDLRNPAAGRLPGSS 1050

  Fly   317 SSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTT 381
            .|    :|...::.:..........|.:.|::    .:|.|     |.|   |....:.:.:...
Mouse  1051 DS----VVFREKKPKEGMGGFSRRCSKLISSQ----LLYQE-----YSD---VVLNKEIQSQQRL 1099

  Fly   382 DNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIR---------------- 430
            |::| ...|......:.:.:......|.|.|   .|||.|..|...|:|
Mouse  1100 DSLA-EPHGLSSPRHRRKALVSSDSYLQRLS---MASSGSLWQEIPVVRNSTVLLSMTHEDQKLQ 1160

  Fly   431 ----ELIDTESNYLDVLTALKTKFM--GPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLT 489
                |||.:|::||..|......|.  ..|...|:..:.:.:|.|::::.|:.|.||..|.|:..
Mouse  1161 EAKFELIVSEASYLRSLNIAVDHFQHSAQLRGTLSNQDHQWLFSRLQDVRDVSTTFLSDLEENFE 1225

  Fly   490 PNA-KVKMAQVFL----DFREPFLIY--------GEFCSLLLGAIDYLADVCKKNQIIDQLVQKC 541
            .|. ..::..|.|    ||...:|.|        ..|.||:           ..|....::::|.
Mouse  1226 NNIFSFQVCDVVLNHAADFHRVYLPYVTNQTYQERTFQSLM-----------NSNSSFREVLEKL 1279

  Fly   542 ERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAM----IDVSQYIN 602
            |.|....:|.|:..|.:|.|||.:..|||..::|.|.|...:.....:|..|:    .|.:..:.
Mouse  1280 ESDPICQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEKLIRDCNSNVQ 1344

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGE---LHIKAHEDQKTKLR---- 660
            .::|..:.:.:.||::.. |.|..|       :.|...|:..||   |........:.||.
Mouse  1345 RMRRTEELIYLSQKIEFE-CKIFPL-------ISQSRWLVKSGELTALEFSVSPGLRRKLTTRPV 1401

  Fly   661 YAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKT 725
            :..:|:..|::.:.   :.|. ::...|....:..|.|:...:........|:..||...:..:.
Mouse  1402 HLHLFNDCLLLSRP---REGS-RFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLLHNAQGTQV 1462

  Fly   726 AFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGR 784
            .|....:::.|:.:|..||....|.|:...|           :|:|..  .|.:..|.|
Mouse  1463 EFLFRTETQSEKLRWISALAMPREELDLLEC-----------YDSPQV--QCLRAYKPR 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	4/13 (31%)
		RhoGEF	428..603	CDD:279015	50/213 (23%)
		PH_Vav	624..753	CDD:269930	25/135 (19%)
		PH	641..749	CDD:278594	20/114 (18%)
		C1_1	761..804	CDD:278556	5/24 (21%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Arhgef5	NP_598435.1	ARHGEF5_35	1..477	CDD:373847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..643
		PHA03247	<398..949	CDD:223021	34/157 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..810		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..1051		46/233 (20%)
		RhoGEF	1164..1340	CDD:366202	48/186 (26%)
		PH_ephexin	1362..1488	CDD:269929	25/137 (18%)
		SH3_ARHGEF5_19	1498..1552	CDD:212873	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910