DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Arhgef7

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_036010059.1	Gene:	Arhgef7 / 54126	MGIID:	1860493	Length:	919	Species:	Mus musculus

Alignment Length:	1013	Identity:	191/1013 - (18%)
Similarity:	326/1013 - (32%)	Gaps:	353/1013 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL-----DPR-EFNRKP 81
            :.|.||....|:....|... |.|: .|..:|:|||:||.|:..|.|.::     :|| |.....
Mouse     6 QTVTWLITLGVLESPKKTIS-DPEV-FLQASLKDGVVLCRLLERLLPGTIEKVYPEPRNESECLS 68

  Fly    82 QMAQFL--CSKNIKL-------------------------------FLDVCHNNFGIRDAD---- 109
            .:.:||  |..:::|                               .||||:..: :.|.:
Mouse    69 NIREFLRACGASLRLEKLDTRTSVSFHLYLKTNQNCDGGGAVGSGDALDVCNQKY-LSDRETSHG 132

  Fly   110 ---------LFEPTMLYDLTNFHRV---LITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDE 162
                     .|:...||...||::|   |:||:|::                          :|.
Mouse   133 VLCLSAAPQTFDANDLYQGQNFNKVLSSLVTLNKVT--------------------------ADI 171

  Fly   163 AIYKDLHSTDLNMRKTSSIDASASSSAEYYDRT-----SQSGSLDENSDITIENGTEDIDDYIED 222
            .:..|......:..:..|.|:..|.|:  :.||     ||..|||
Mouse   172 GLGSDSVCARPSSHRIKSFDSLGSQSS--HSRTSKLLQSQYRSLD-------------------- 214

  Fly   223 SLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT-------DGASNAVTP- 279
                |.|:|      ::.:......:.|.::..||||... ||:..|.       :|..|..|.
Mouse   215 ----MTDNT------NSQLVVRAKFNFQQTNEDELSFSKG-DVIHVTRVEEGGWWEGTHNGRTGW 268

  Fly   280 TPESYARQSQSPLAAAAPS-VPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYN-YRS 342
            .|.:|.|:.:       || .|||    |..|.|.|......:..:::|         .|| ...
Mouse   269 FPSNYVREIK-------PSEKPVS----PKSGTLKSPPKGFDTTAINKS---------YYNVVLQ 313

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
            ::..||||    ||::.:.|        .....:|..|:|.::...|.|...|.:|...:|.:..
Mouse   314 NILETEHE----YSKELQSV--------LSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLV 366

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
               .|..:...|...:||         ....:|.::..::|.::.....|          |....
Mouse   367 ---QSLEECTKSPEAQQR---------VGGCFLSLMPQMRTLYLAYCANH----------PSAVS 409

  Fly   473 LVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
            ::..|::.|                             |||
Mouse   410 VLTEHSEDL-----------------------------GEF------------------------ 421

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
             .:.:...:.|.|.|...||.|..|:.||..||.:|.:.....|.|.:.::::..|..::|....
Mouse   422 -METKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQ 485

  Fly   603 EV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            || ||....|.|:.:.         :::..|.|:...|.:....::.|:....::...||..:|.
Mouse   486 EVRKRKELELQILTEP---------IRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFP 541

  Fly   667 KILIMVKAL----------HIKTGDMQYT-------YRDSHNLADYRVEQSHSRRTIGRD----- 709
            .:|:|:.|.          .:.|..|..|       :|::..::...:|:.....|..:|
Mouse   542 NLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWV 606

  Fly   710 TRFKYQLLLARKSGKT------------AFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHK 762
            ...:.|..:...|..|            :..|...|:| .|....|||.|..:|..|....|.|.
Mouse   607 EHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKH-ADSKPVALTPAYHTLPHPSHHGTPHT 670

  Fly   763 MEIY-TFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI-------SSTGRCKQNPVSVPPP 819
            ...: ..:.|.|.:..|                     ..|:       .|...|.:..:|..|.
Mouse   671 TISWGPLEPPKTPKPWS---------------------LSCLRPAPPLRPSAALCYKEDLSKSPK 714

  Fly   820 VCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMK 884
            ...:.|.:........|.|.|..:                  |||       :|:.|..::|.::
Mouse   715 TMKKLLPKRKPERKPSDEEFAVRK------------------STA-------ALEEDAQILKVIE 754

  Fly   885 INQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGEN 922
                      .||.|:    ||...|.|.::..||..|
Mouse   755 ----------AYCTSA----KTRQTLNSTWQGTDLMHN 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	38/163 (23%)
		RhoGEF	428..603	CDD:279015	25/174 (14%)
		PH_Vav	624..753	CDD:269930	29/162 (18%)
		PH	641..749	CDD:278594	25/141 (18%)
		C1_1	761..804	CDD:278556	5/50 (10%)
		SH2_Vav_family	824..934	CDD:198193	20/99 (20%)
		SH3	940..993	CDD:302595
Arhgef7	XP_036010059.1	CH_SF	3..172	CDD:412120	40/194 (21%)
		RhoGEF67_u1	174..220	CDD:406911	15/77 (19%)
		SH3_betaPIX	224..277	CDD:212994	14/53 (26%)
		RhoGEF	308..485	CDD:238091	46/264 (17%)
		PH_Cool_Pix	516..614	CDD:269932	15/97 (15%)
		RhoGEF67_u2	670..768	CDD:374671	24/157 (15%)
		betaPIX_CC	830..916	CDD:406829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910