DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and PLCG2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_002652.2	Gene:	PLCG2 / 5336	HGNCID:	9066	Length:	1265	Species:	Homo sapiens

Alignment Length:	927	Identity:	188/927 - (20%)
Similarity:	312/927 - (33%)	Gaps:	330/927 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 VSTSSSSSSLLVSESQRLQRA-----AAAVYNYRSSMASTEHEYAYIY----------------- 355
            :||:.:..||...|..:::||     ...|:::|.|  :.|.....:.
Human     1 MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKS--TPERRTVQVIMETRQVAWSKTADKIEG 63

  Fly   356 ---------------SEDDEKV-----YEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEE 400
                           |:|.|:.     .||.|: |.....:..::|.::|        .::||:.
Human    64 FLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCF-TILYGTQFVLSTLSLA--------ADSKEDA 119

  Fly   401 V--YQDLCALHRTS-------------RSQTASSTSFEQRDYVIRELIDTESNYLDVLT------ 444
            |  ...|..||:.:             |.|..|.....:....:|||    ...|.::.
Human   120 VNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLREL----KTILPLINFKVSSA 180

  Fly   445 -ALKTKFMGPLERHLNQDEL----------RLIFPRIRELVD----------------------- 475
             .||.||   :|...::|||          :|:|.:.:.::|
Human   181 KFLKDKF---VEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVY 242

  Fly   476 --------IH------TKFLDKLRESLTPNAKVKMAQVFLD-----FREPFLIYGEFCSLLLGAI 521
                    ||      .:.|:|:||.:|.         |:|     ..||||...||.:.|..
Human   243 LHDFQRFLIHEQQEHWAQDLNKVRERMTK---------FIDDTMRETAEPFLFVDEFLTYLFS-- 296

  Fly   522 DYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKY---------HLLLDKLVKET 577
                   ::|.|.|:       .|:...:|       .|...|.:         :|..|:|..|:
Human   297 -------RENSIWDE-------KYDAVDMQ-------DMNNPLSHYWISSSHNTYLTGDQLRSES 340

  Fly   578 SP------LHDDYRSLE-------RAKEAMIDVSQYINEVKRDSDHLVIIQKVKD---------- 619
            ||      |....|.:|       ..|..:........::|.|.    ::|.:||
Human   341 SPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDD----VVQAIKDHAFVTSSFPV 401

  Fly   620 --SI---CDIHLLQNGNGSDLLQYGRLLLDGELHIKAHE-DQKTKLRYAFVFDKILIMVKALHIK 678
              ||   |.:...::...:....:|.|||.......|.: ...::||     :||:|..|.|..:
Human   402 ILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLR-----EKIIIKHKKLGPR 461

  Fly   679 TGDMQYTYRDSHNLADYRVEQSHSRRTIGRD------TRFKYQLLLARKSGKTAFTLYLKSE--- 734
             ||:..      |:.|.:.|..........|      ||....:..|:.|........::.|
Human   462 -GDVDV------NMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQ 519

  Fly   735 -------HERDKWRKALTE---AMESLEPPGCQSTDHK------MEIYTFDAPTTCRHCSKFLKG 783
                   |..:||.....|   :.|.|....|..|..|      .|..||....|   .|.:..|
Human   520 DIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYT---LSFWRSG 581

  Fly   784 RIHQGYRCKVCQISVHKGCI---------------------SSTGRCKQNPVSVPPPVCDRQLSE 827
            |:.   .|:: :.::..|.:                     .:..||.:..:.:..||.:....|
Human   582 RVQ---HCRI-RSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHE 642

  Fly   828 FN-WFAGNMDRETAAHRLEN-RRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENS 890
            .. |:..::.|..|...|.. .|.|.:|:|.|....|      ||::.:....| ||.:||:
Human   643 SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDS------YAITFRARGKV-KHCRINR--- 697

  Fly   891 GDSMLYCLSSRRHFKTIVELVSYYERNDLGENF-------------------------------- 923
             |...:.|.:..:|:::||||||||::.|....
Human   698 -DGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVD 761

  Fly   924 -AGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQ-VLVIGKDGDSKGWWRGKIGDTV-GY 985
             :.:|.|:  |.:.|  .|||||:.|. |::|..   |: .|:.....:..|||:|..|..: .|
Human   762 PSEINPSM--PQRTV--KALYDYKAKR-SDELSF---CRGALIHNVSKEPGGWWKGDYGTRIQQY 818

  Fly   986 FPKEYVQEQKLAS-EEL 1001
            ||..||::...|. |||
Human   819 FPSNYVEDISTADFEEL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/255 (19%)
		PH_Vav	624..753	CDD:269930	29/148 (20%)
		PH	641..749	CDD:278594	26/127 (20%)
		C1_1	761..804	CDD:278556	10/69 (14%)
		SH2_Vav_family	824..934	CDD:198193	32/144 (22%)
		SH3	940..993	CDD:302595	20/54 (37%)
PLCG2	NP_002652.2	PH_PLC_gamma	22..140	CDD:270168	19/128 (15%)
		PH-like	235..>276	CDD:302622	9/49 (18%)
		PI-PLCc_gamma	311..>458	CDD:176534	32/162 (20%)
		PH-like	475..>510	CDD:302622	5/34 (15%)
		SH2_N-SH2_PLC_gamma_like	527..627	CDD:199829	20/106 (19%)
		SH2_C-SH2_PLC_gamma_like	641..744	CDD:198186	30/113 (27%)
		SH3_PLCgamma2	773..827	CDD:212902	21/59 (36%)
		PHsplit_PLC_gamma	<840..910	CDD:270054
		PI-PLCc_GDPD_SF	<926..1031	CDD:301322
		C2_PLC_like	1061..1187	CDD:175974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910