Sequence 1: | NP_001097030.1 | Gene: | Vav / 32920 | FlyBaseID: | FBgn0040068 | Length: | 1001 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_082303.2 | Gene: | Arhgef25 / 52666 | MGIID: | 1277173 | Length: | 618 | Species: | Mus musculus |
Alignment Length: | 508 | Identity: | 111/508 - (21%) |
---|---|---|---|
Similarity: | 196/508 - (38%) | Gaps: | 100/508 - (19%) |
- Green bases have known domain annotations that are detailed below.
Fly 276 AVTPTPESYA-RQSQSPLAAAA---------PSVPVSA------APGPPMGRLVSTSSSSSSLLV 324
Fly 325 -SESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNG 388
Fly 389 TGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGP 453
Fly 454 LERHLNQDEL----RLIFPRIRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGE 512
Fly 513 FCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKET 577
Fly 578 SPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLL 642
Fly 643 LDGELHIKAHE-----DQKTKLRYAFVFDKILIMVKAL-HIKTGDMQ--YTYRDSHNLADYRVEQ 699
Fly 700 SHSRRTIGRDTRFKYQLLLAR--KSGKTAFTLYLKSEHERDKWRKALTEAMES 750 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Vav | NP_001097030.1 | CH | 20..132 | CDD:278723 | |
RhoGEF | 428..603 | CDD:279015 | 49/180 (27%) | ||
PH_Vav | 624..753 | CDD:269930 | 30/137 (22%) | ||
PH | 641..749 | CDD:278594 | 25/117 (21%) | ||
C1_1 | 761..804 | CDD:278556 | |||
SH2_Vav_family | 824..934 | CDD:198193 | |||
SH3 | 940..993 | CDD:302595 | |||
Arhgef25 | NP_082303.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..63 | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 169..193 | 6/29 (21%) | |||
RhoGEF | 203..374 | CDD:279015 | 49/180 (27%) | ||
Important for binding to Rho GTPases. /evidence=ECO:0000250 | 317..338 | 10/25 (40%) | |||
PH2_Kalirin_Trio_p63RhoGEF | 378..520 | CDD:270061 | 30/147 (20%) | ||
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 | 506..532 | 1/1 (100%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 521..556 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 584..604 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.910 |