DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and Arhgef25

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_082303.2 Gene:Arhgef25 / 52666 MGIID:1277173 Length:618 Species:Mus musculus


Alignment Length:508 Identity:111/508 - (21%)
Similarity:196/508 - (38%) Gaps:100/508 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 AVTPTPESYA-RQSQSPLAAAA---------PSVPVSA------APGPPMGRLVSTSSSSSSLLV 324
            |..|.||||: ..|:..::|:|         ||..:|:      .|||..|.......|...|.|
Mouse    66 AWAPQPESYSIAVSEGSMSASAVSGLAALSGPSSGLSSDPCSPIPPGPVTGLRRWLDHSKHCLSV 130

  Fly   325 -SESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNG 388
             :|::..|......:....::.:                          .:..||:|.......|
Mouse   131 ETEAESGQTGQCENWTLEPTLTT--------------------------GQELPELTLLTTLLEG 169

  Fly   389 TGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGP 453
            .| |.....|||...     ......:.....:.|:..:|:.||::||..|:|.|..:...:|..
Mouse   170 PG-DKAQPAEEETLS-----QAPKNEEEQKKMALERSMFVLGELVETERTYVDDLGQIVEGYMAT 228

  Fly   454 LERHLNQDEL----RLIFPRIRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGE 512
            :......:.|    |::|..|:::.:.|.. ||.:|::.| .|:   .:||:|:.......:|..
Mouse   229 MATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPD---WLAQLFIKHERRLHMYVV 290

  Fly   513 FCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKET 577
            :|.....:...|::.  .:...::|.|:...     :|||.|:|..|:|||:||.|||...:|..
Mouse   291 YCQNKPKSEHVLSEF--GDSYFEELRQQLGH-----RLQLNDLLIKPVQRIMKYQLLLKDFLKYY 348

  Fly   578 SPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLL 642
            .....|...||:|.|.|..|.:..|:       ::.:.:::           |....|...|:||
Mouse   349 RRAGKDTEELEQAVEVMCFVPKRCND-------MMSLGRLR-----------GFEGKLTAQGKLL 395

  Fly   643 LDGELHIKAHE-----DQKTKLRYAFVFDKILIMVKAL-HIKTGDMQ--YTYRDSHNLADYRVEQ 699
            ......:...|     ..:.:.|..|:|::|:|..:|| ....|..|  |.|::|..::...:|.
Mouse   396 GQDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPGYVYKNSIKVSCLGLEG 460

  Fly   700 SHSRRTIGRDTRFKYQLLLAR--KSGKTAFTLYLKSEHERDKWRKALTEAMES 750
            :..    |...||   .|.:|  :.|...:.|..........|.|.:.:.:||
Mouse   461 NLQ----GNPCRF---ALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILES 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 49/180 (27%)
PH_Vav 624..753 CDD:269930 30/137 (22%)
PH 641..749 CDD:278594 25/117 (21%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
Arhgef25NP_082303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..193 6/29 (21%)
RhoGEF 203..374 CDD:279015 49/180 (27%)
Important for binding to Rho GTPases. /evidence=ECO:0000250 317..338 10/25 (40%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 30/147 (20%)
Sufficient to bind activated GNAQ. /evidence=ECO:0000250 506..532 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 584..604
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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