Protein Alignment Vav and ARHGEF4

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001354422.1
• Gene: ARHGEF4 / 50649
• HGNCID: 684
• Length: 1876
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 119/556 - (21%)
• Similarity: 212/556 - (38%)
• Gaps: 117/556 - (21%)

  Fly   271 DGAS---NAVTPTPESYARQSQS-PLAAAAPS----------VPVSAAPGPPMGRLVSTSSSSSS 321
            ||..   ..:..:|||.....:| ||:.:||:          .|.:|.|...:...|......|.
Human  1283 DGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSE 1347

  Fly   322 LLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIAC 386
                         ..:|:   .:.|:.|.|::.....::....:|            ::..::.|
Human  1348 -------------EDLYD---DLHSSSHHYSHPGGGGEQLAINEL------------ISDGSVVC 1384

  Fly   387 NGTGYDHTNTKEEE---------------------------------------VYQDLCA----- 407
            ....:||....::|                                       |.||..|
Human  1385 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDDAP 1449

  Fly   408 LHRTSRSQ----TASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERH---LNQDELRL 465
            |...|.::    .|.|:..:.|..||.|::.||.:|:..|..:...::....:.   .::::||.
Human  1450 LAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRT 1514

  Fly   466 IFPRIRELVDIHTKFLDKLRESLT---PNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADV 527
            ||..|.::......|:..|.:...   |:.. ::...||:.:..|.||.|:|:....|...|:.:
Human  1515 IFGNIEDIYRCQKAFVKALEQRFNRERPHLS-ELGACFLEHQADFQIYSEYCNNHPNACVELSRL 1578

  Fly   528 CKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKE 592
            .|.::.: ...:.|.....:..:.|...|..|:|:|.||.|.|.:|:|.|.|.|.|::.:|.|..
Human  1579 TKLSKYV-YFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALH 1642

  Fly   593 AMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLL-QYGRLLLDGELHIKAHEDQK 656
            ||.:|:|.|||.||..:::..|.:.:.||      ::..|.||| :...|:..|||........|
Human  1643 AMKNVAQLINERKRRLENIDKIAQWQSSI------EDWEGEDLLVRSSELIYSGELTRVTQPQAK 1701

  Fly   657 TKLRYAFVFDKILIMVKALHIKTGDMQYTYR-DSHNLADYRVEQSHSRRTIGRD----TRFKYQL 716
            ::.|..|:||..||..|...::...:.|..| |...|....:|.       |:|    ...|...
Human  1702 SQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLED-------GKDRDLHVSIKNAF 1759

  Fly   717 LLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLE 752
            .|.|.:...:..|..:...::.:|.||.....|.::
Human  1760 RLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQ 1795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/180 (27%)
		PH_Vav	624..753	CDD:269930	31/135 (23%)
		PH	641..749	CDD:278594	26/112 (23%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
ARHGEF4	NP_001354422.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940