DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Fgd6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001131117.1	Gene:	Fgd6 / 500824	RGDID:	1565609	Length:	1406	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	145/669 - (21%)
Similarity:	263/669 - (39%)	Gaps:	167/669 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVT---------FQAKAKPEVTT 381
            :.|.|.|.|:.   ..||.:....||..:...::...||:|.:|.         :|..:..|.|.
  Rat   705 DDQMLSRHASC---QASSTSDCGPEYENVRHYEEIPEYENLPFVMARGNPPELGWQNSSSVEDTD 766

  Fly   382 DNIACNGTGYD------------------HTNTKEEEVYQDLCA----LHRTSRSQTASSTSFEQ 424
            .::......||                  ....:::|::.||.:    ::.:.....:|.:|..:
  Rat   767 VSLYEVEEPYDAPDGQLQLDPRHQPCSSGRCQDRQDELHLDLPSDEEVINSSDEDDVSSESSKGE 831

  Fly   425 RD-----------------YVIRELIDTESNYLDVLTALKTKFMGPL-------------ERHLN 459
            .|                 ::.:|::.:|..::|||..|...|.|.:             :|.||
  Rat   832 PDPLEDKQDEDAGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRGAVAHASRQLGKPVIEDRILN 896

  Fly   460 QDELRLIFPRIRELVDIHTKFLDKLRESLTPNA-KVKMAQVFLDFREPFL-IYGEFCSLLLGAID 522
            |     |...:.:|.:::...|.:|.|.:...| :.::|.:|:. :.|:| :|..:.......|.
  Rat   897 Q-----ILYYLPQLYELNRDLLKELEERMLSWAEQQRIADIFVK-KGPYLKMYSMYIKEFDKNIA 955

  Fly   523 YLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSL 587
            .|.:.||||.....:|::.|.......|.|:..|..|:|||.:|.|||...:|.......|:|..
  Rat   956 LLDEQCKKNSGFATVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLLEDSVDHRDT 1020

  Fly   588 ERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAH 652
            :.|...:|:|:.:.|:..:..|:...:.:::.|:...|        :::|.||:.|...:.:|..
  Rat  1021 QDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLSGHH--------EIVQPGRVFLKEGILMKLS 1077

  Fly   653 EDQKTKLRYAFVFDKILIMVKALHIKTGDMQ---YTYRDSHNLADYRVEQSHSRRTIGRDTRFKY 714
            . :..:.|..|:|:..|:.       |..||   |...:..:||..:|.         :.|:..|
  Rat  1078 R-KVMQPRMIFLFNDALLY-------TTPMQSGMYKLNNMLSLAGMKVR---------KPTQEAY 1125

  Fly   715 QLLLARKSGKTAFTLYLKSEHERDKWRKALTEAME-------------SLEPPGCQSTDHKMEIY 766
            |..|..:|.:.:|.|...|..|||.|.:|::.|:|             ||:    :.::.|.|:.
  Rat  1126 QNELKIESVERSFILSASSASERDDWLEAISRAIEEYAKKRITFCPSRSLD----EDSERKEEVS 1186

  Fly   767 TFDA----------PTTCRHC-SKF-LKGRIHQGYRCKVCQISVHKGCISSTGRC-----KQNPV 814
            ...|          .|.|..| |:| |..|.|   .|:.|...|.:.|  |:.:|     |..|.
  Rat  1187 PLGAKAPIWIPDTRATMCMICTSEFTLTWRRH---HCRACGKIVCQAC--SSNKCGLDYLKGQPA 1246

  Fly   815 SVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRP---QGPSTA-----HETMYAL 871
            .| ..:|.::|.:.:            |:| :.|||:      |   :.||:|     |......
  Rat  1247 RV-CELCFQELQKLD------------HQL-SPRIGS------PGNHKSPSSALSSVLHSIPSGR 1291

  Fly   872 SLKTDDNVIKHMKINQENS 890
            ..|.....:|.:..|.|:|
  Rat  1292 KQKKIPAALKEVSANTEDS 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/189 (25%)
		PH_Vav	624..753	CDD:269930	34/144 (24%)
		PH	641..749	CDD:278594	27/110 (25%)
		C1_1	761..804	CDD:278556	15/54 (28%)
		SH2_Vav_family	824..934	CDD:198193	16/75 (21%)
		SH3	940..993	CDD:302595
Fgd6	NP_001131117.1	RhoGEF	852..1036	CDD:279015	48/189 (25%)
		PH1_FGD6	1054..1176	CDD:275436	33/146 (23%)
		PH	1069..1160	CDD:278594	26/107 (24%)
		FYVE_FGD6	1193..1253	CDD:277282	17/65 (26%)
		PH	1311..1402	CDD:278594	145/669 (22%)
		PH2_FGD5_FGD6	1312..1400	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910