DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and net1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021330686.1	Gene:	net1 / 493607	ZFINID:	ZDB-GENE-041121-18	Length:	605	Species:	Danio rerio

Alignment Length:	723	Identity:	147/723 - (20%)
Similarity:	243/723 - (33%)	Gaps:	266/723 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RKTSSIDASASSSAEYYDRTSQSGSLDENS-----------DITIENGTEDIDDYIEDSLSNMCD 229
            ||:|.::|..|.     :||.:..||...|           |.|::....:.||  .|::| :|
Zfish    24 RKSSMVEADGSP-----ERTFKRPSLRRGSSFTFLTPGPQWDFTLKRKRREKDD--ADAVS-LC- 79

  Fly   230 STIDNDAEDAGVETPLLSDCQGSHVRELSFDL---------ALDVVSSTTDGASNAVTPTPESYA 285
                                        |||.         .|..|:|    .:|.::|......
Zfish    80 ----------------------------SFDFKEPCTKRVRPLGRVTS----LANLISPVKNGAV 112

  Fly   286 RQSQSPLAAA------APSVP------VSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVY 338
            |:....|.|:      :|.||      .:|||.||..|        :|.|.||:..:.:..
Zfish   113 RRFGQTLQASFRGDGRSPGVPQQKPCSKAAAPTPPKRR--------NSTLWSETLDVHQKG---- 165

  Fly   339 NYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQ 403
                                           ||..|                    ..|.:|
Zfish   166 -------------------------------TFSTK--------------------EIKRQE--- 176

  Fly   404 DLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFP 468
               |:...||.         ::| :|.:|......|.|.:  ||...|       :::||..||.
Zfish   177 ---AIFELSRG---------EQD-LIEDLKLARKAYHDPM--LKLSIM-------SEEELTAIFG 219

  Fly   469 RIRELVDIHTKFLDKLRESLTPNAKVK-MAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQ 532
            .:...:.:|...||:|.::...:..|: :.::.:|:......|..:||..|.| ..|.|..|::.
Zfish   220 DLDAYIPLHEDLLDQLAKATGTDGTVRQIGKIVVDWLPRLNAYRAYCSNQLAA-KALLDQKKQDP 283

  Fly   533 IIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDV 597
            .:...:|:|.......||.|...|.:|..|::||.|||.::::.|.|.|.|..|||:|...:..|
Zfish   284 RVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPPDHPDKGSLEQAISVIQAV 348

  Fly   598 SQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYA 662
            ...||..|.:|:....|.|::      :|........:.|...||..|||..|:    .||| :.
Zfish   349 LADINMKKGESECQYYIDKLE------YLEDKQKDPRIEQCKSLLCHGELRNKS----GTKL-HV 402

  Fly   663 FVFDKILIMVKAL-----------------------HIKTGDMQY--TYRDSHNLAD-----YRV 697
            |:|.::||:.:.:                       .::.||::.  ::|.:.:.||     :||
Zfish   403 FLFTEVLILTRPVTRNDRHCFQVYRQPIPVQDLVLEDLQDGDVRMGGSFRGAFSNADKAKNIFRV 467

  Fly   698 E-------QSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESL---- 751
            .       |||                          ||.:.....:.:|...|..||.:.
Zfish   468 RFQDASQGQSH--------------------------TLQVNDVFHKQQWLNCLRNAMSTQKDLT 506

  Fly   752 ----EPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQI-SVHKGCISSTGRCKQ 811
                ||....:||               .|:|.....:     ..|.|: .:.:.|..:......
Zfish   507 LSENEPLTTPATD---------------VCAKRRSSSV-----STVIQMDEMDENCPRAAASAPS 551

  Fly   812 NPVSVPPP 819
            :|.|..||
Zfish   552 SPSSEEPP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/175 (27%)
		PH_Vav	624..753	CDD:269930	31/173 (18%)
		PH	641..749	CDD:278594	28/144 (19%)
		C1_1	761..804	CDD:278556	5/43 (12%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
net1	XP_021330686.1	RhoGEF	177..353	CDD:214619	51/195 (26%)
net1	XP_021330686.1	PH-like	367..500	CDD:327399	31/169 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910