DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and stac3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001003505.1	Gene:	stac3 / 445111	ZFINID:	ZDB-GENE-040801-248	Length:	334	Species:	Danio rerio

Alignment Length:	307	Identity:	64/307 - (20%)
Similarity:	102/307 - (33%)	Gaps:	110/307 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 TLYLKSEHERDKWRKALTEAMESLEPPG----CQSTD--HKMEIYTFDAPTTCRHCSKFLKGRIH 786
            |:|...:.|        .|..|:..||.    .|..|  ||.:.:....|..|..|::.:.....
Zfish    32 TVYFVYDEE--------VEEEEAPPPPTPEPIVQVNDKPHKFKDHYCKKPKFCDVCARMIVLNNK 88

  Fly   787 QGYRCKVCQISVHKGCIS--STGRCKQNPVSVPP--------PVCDRQLSEFNWFAGNMDRETAA 841
            ...|||.|:.::|..|.|  ...||..   .:||        |:.|::::.    .|..:|....
Zfish    89 FALRCKNCKTNIHHSCQSYVQFQRCFG---KIPPGFRRAYSSPLYDQEINN----PGQQNRTDPV 146

  Fly   842 HRLENRRIGTYLLRVRPQGPSTAHETMYALSLK---------------------------TDDNV 879
              .:..|:|..:.....:..|...:.|..:.::                           |||
Zfish   147 --FDTLRVGVIMANKERKKGSEDKKNMMMMMMEEEEAQQPKEDEEGAEGKQDGDKKDKTATDD-- 207

  Fly   880 IKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYD 944
             |:.| .|:....|..|....|  ||.|       |::||                        |
Zfish   208 -KNKK-QQQTFSQSHYYMALYR--FKAI-------EKDDL------------------------D 237

  Fly   945 YEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYV 991
            :.|  |.         ::.|:  |..::.|||||||:..||.|..|:
Zfish   238 FHP--GD---------RITVL--DDSNEEWWRGKIGEKTGYLPMTYI 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	5/24 (21%)
		PH	641..749	CDD:278594	4/20 (20%)
		C1_1	761..804	CDD:278556	11/42 (26%)
		SH2_Vav_family	824..934	CDD:198193	21/136 (15%)
		SH3	940..993	CDD:302595	16/52 (31%)
stac3	NP_001003505.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		C1	63..108	CDD:237996	12/44 (27%)
		STAC2_u1	120..>197	CDD:293269	8/82 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..215		6/40 (15%)
		SH3	221..273	CDD:302595	24/97 (25%)
		SH3	280..330	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910