DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and UNC13C

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001074003.1	Gene:	UNC13C / 440279	HGNCID:	23149	Length:	2214	Species:	Homo sapiens

Alignment Length:	932	Identity:	172/932 - (18%)
Similarity:	309/932 - (33%)	Gaps:	286/932 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 FNLQLSPTERSHSDEAIYKDLHSTDLN----MRKTSSIDASASSSAEYYDRTSQSGS---LDENS 205
            |..:||   ||.||.:.....:|.|.:    ..:|:.....:||..|.:.| .|.|:   .|...
Human   542 FTAKLS---RSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQR-KQEGTATLYDSPK 602

  Fly   206 DITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELS--------FDLA 262
            |..:..|.:.|....|...:...||.:.|....|..:....||.|.|...:||        .||.
Human   603 DQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLG 667

  Fly   263 LDVVSSTTDG---ASNA-------VTPTPESYARQSQSPLAAAAPSVPV------SAAPG---PP 308
            ||  |||.:|   .:|:       |......|..:..|.|...:.|..:      |..||   .|
Human   668 LD--SSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEP 730

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSED------DEKVYEDLC 367
            .|:.|....|......:|..:.|...:.:|..:|.:.|.:       |||      ..::..||.
Human   731 QGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDD-------SEDAPPKSWHSRLSIDLS 788

  Fly   368 YVTF----------QAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTA--SST 420
            ..||          :||:..||..:....:.:||:.:.:       .|....||....||  |||
Human   789 DKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGS-------SLMGRFRTLSQSTANESST 846

  Fly   421 SF--------------EQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIR 471
            :.              ::.||. ..:.|.|::|::|:..:..|    ||.
Human   847 TLDSDVYTEPYYYKAEDEEDYT-EPVADNETDYVEVMEQVLAK----LEN--------------- 891

  Fly   472 ELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
                         |.|:|...:...|...|.:..|:
Human   892 -------------RTSITETDEQMQAYDHLSYETPY----------------------------- 914

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKE--TSPLHDDYRSLERAKEAMIDVSQ 599
                 |...:.|                 |....|.:|.|  ..||::....:|..::...::.:
Human   915 -----ETPQDEG-----------------YDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPE 957

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFV 664
            ...|:.:.       ::::.|.                       .|..::|::.|..:|.
Human   958 QPVEITKP-------KRIRPSF-----------------------KEAALRAYKKQMAELE---- 988

  Fly   665 FDKIL------IMVKALHIKTGDMQYTYRDSHNLAD------YRVEQSHSRR-----TIGRDTRF 712
             :|||      :..||..:...|:..:...:..:..      |.::.....|     .|.||..
Human   989 -EKILAGDSSSVDEKARIVSGNDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVA- 1051

  Fly   713 KYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHC 777
              ..|.|||||.:...:...|.:..:.......:.:::|..|...:..|..|::|...||.|..|
Human  1052 --MTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYEC 1114

  Fly   778 SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDR-ETAA 841
            ...|.|...||.:|..|.:..|:.|        |:.::..   |.::.:|.:...|..|: :|..
Human  1115 EGLLWGIARQGMKCLECGVKCHEKC--------QDLLNAD---CLQRAAEKSSKHGAEDKTQTII 1168

  Fly   842 HRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKT 906
            ..::.|      :::|.:......|.:..:...:.::.::..|..:::..|.     :|:...|.
Human  1169 TAMKER------MKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDG-----TSKWSAKI 1222

  Fly   907 IVELVSY--------------YERNDLGEN-------FAGLNQSLQWPYKEVIATALYDYEPKAG 950
            .:.:||.              |....:|:|       |..||.  .|..|       :.:|....
Human  1223 TITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNP--VWDEK-------FYFECHNS 1278

  Fly   951 SNQLQLRTDCQVLVIGKDGDSK 972
            ::::::|      |..:|.|.|
Human  1279 TDRIKVR------VWDEDDDIK 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	22/176 (13%)
		PH_Vav	624..753	CDD:269930	23/145 (16%)
		PH	641..749	CDD:278594	22/124 (18%)
		C1_1	761..804	CDD:278556	15/42 (36%)
		SH2_Vav_family	824..934	CDD:198193	20/131 (15%)
		SH3	940..993	CDD:302595	6/33 (18%)
UNC13C	NP_001074003.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..458
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..518
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..629		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..739		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..780		5/25 (20%)
		C1	1098..1147	CDD:237996	16/59 (27%)
		C2B_Munc13	1220..1346	CDD:175993	17/90 (19%)
		DUF1041	1541..1646	CDD:283860
		Membr_traf_MHD	1888..2024	CDD:287505
		C2C_Munc13	2062..2181	CDD:176041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910