DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and UNC13C

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001074003.1 Gene:UNC13C / 440279 HGNCID:23149 Length:2214 Species:Homo sapiens


Alignment Length:932 Identity:172/932 - (18%)
Similarity:309/932 - (33%) Gaps:286/932 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 FNLQLSPTERSHSDEAIYKDLHSTDLN----MRKTSSIDASASSSAEYYDRTSQSGS---LDENS 205
            |..:||   ||.||.:.....:|.|.:    ..:|:.....:||..|.:.| .|.|:   .|...
Human   542 FTAKLS---RSESDFSKLCQSYSEDFSENQFFTRTNGSSLLSSSDRELWQR-KQEGTATLYDSPK 602

  Fly   206 DITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELS--------FDLA 262
            |..:..|.:.|....|...:...||.:.|....|..:....||.|.|...:||        .||.
Human   603 DQHLNGGVQGIQGQTETENTETVDSGMSNGMVCASGDRSHYSDSQLSLHEDLSPWKEWNQGADLG 667

  Fly   263 LDVVSSTTDG---ASNA-------VTPTPESYARQSQSPLAAAAPSVPV------SAAPG---PP 308
            ||  |||.:|   .:|:       |......|..:..|.|...:.|..:      |..||   .|
Human   668 LD--SSTQEGFDYETNSLFDQQLDVYNKDLEYLGKCHSDLQDDSESYDLTQDDNSSPCPGLDNEP 730

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSED------DEKVYEDLC 367
            .|:.|....|......:|..:.|...:.:|..:|.:.|.:       |||      ..::..||.
Human   731 QGQWVGQYDSYQGANSNELYQNQNQLSMMYRSQSELQSDD-------SEDAPPKSWHSRLSIDLS 788

  Fly   368 YVTF----------QAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTA--SST 420
            ..||          :||:..||..:....:.:||:.:.:       .|....||....||  |||
Human   789 DKTFSFPKFGSTLQRAKSALEVVWNKSTQSLSGYEDSGS-------SLMGRFRTLSQSTANESST 846

  Fly   421 SF--------------EQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIR 471
            :.              ::.||. ..:.|.|::|::|:..:..|    ||.               
Human   847 TLDSDVYTEPYYYKAEDEEDYT-EPVADNETDYVEVMEQVLAK----LEN--------------- 891

  Fly   472 ELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQ 536
                         |.|:|...:...|...|.:..|:                             
Human   892 -------------RTSITETDEQMQAYDHLSYETPY----------------------------- 914

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKE--TSPLHDDYRSLERAKEAMIDVSQ 599
                 |...:.|                 |....|.:|.|  ..||::....:|..::...::.:
Human   915 -----ETPQDEG-----------------YDGPADDMVSEEGLEPLNETSAEMEIREDENQNIPE 957

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFV 664
            ...|:.:.       ::::.|.                       .|..::|::.|..:|.    
Human   958 QPVEITKP-------KRIRPSF-----------------------KEAALRAYKKQMAELE---- 988

  Fly   665 FDKIL------IMVKALHIKTGDMQYTYRDSHNLAD------YRVEQSHSRR-----TIGRDTRF 712
             :|||      :..||..:...|:..:...:..:..      |.::.....|     .|.||.. 
Human   989 -EKILAGDSSSVDEKARIVSGNDLDASKFSALQVCGGAGGGLYGIDSMPDLRRKKTLPIVRDVA- 1051

  Fly   713 KYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHC 777
              ..|.|||||.:...:...|.:..:.......:.:::|..|...:..|..|::|...||.|..|
Human  1052 --MTLAARKSGLSLAMVIRTSLNNEELKMHVFKKTLQALIYPMSSTIPHNFEVWTATTPTYCYEC 1114

  Fly   778 SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDR-ETAA 841
            ...|.|...||.:|..|.:..|:.|        |:.::..   |.::.:|.:...|..|: :|..
Human  1115 EGLLWGIARQGMKCLECGVKCHEKC--------QDLLNAD---CLQRAAEKSSKHGAEDKTQTII 1168

  Fly   842 HRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKT 906
            ..::.|      :::|.:......|.:..:...:.::.::..|..:::..|.     :|:...|.
Human  1169 TAMKER------MKIREKNRPEVFEVIQEMFQISKEDFVQFTKAAKQSVLDG-----TSKWSAKI 1222

  Fly   907 IVELVSY--------------YERNDLGEN-------FAGLNQSLQWPYKEVIATALYDYEPKAG 950
            .:.:||.              |....:|:|       |..||.  .|..|       :.:|....
Human  1223 TITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNP--VWDEK-------FYFECHNS 1278

  Fly   951 SNQLQLRTDCQVLVIGKDGDSK 972
            ::::::|      |..:|.|.|
Human  1279 TDRIKVR------VWDEDDDIK 1294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 22/176 (13%)
PH_Vav 624..753 CDD:269930 23/145 (16%)
PH 641..749 CDD:278594 22/124 (18%)
C1_1 761..804 CDD:278556 15/42 (36%)
SH2_Vav_family 824..934 CDD:198193 20/131 (15%)
SH3 940..993 CDD:302595 6/33 (18%)
UNC13CNP_001074003.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 29..50
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..458
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..518
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..629 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..739 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..780 5/25 (20%)
C1 1098..1147 CDD:237996 16/59 (27%)
C2B_Munc13 1220..1346 CDD:175993 17/90 (19%)
DUF1041 1541..1646 CDD:283860
Membr_traf_MHD 1888..2024 CDD:287505
C2C_Munc13 2062..2181 CDD:176041
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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