DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and PLEKHG7

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001364258.1	Gene:	PLEKHG7 / 440107	HGNCID:	33829	Length:	691	Species:	Homo sapiens

Alignment Length:	461	Identity:	94/461 - (20%)
Similarity:	171/461 - (37%)	Gaps:	106/461 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 GYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNY-LDVLTALKTKFMGP 453
            |||....|::...:.|...|:....|    ...:::...:.||..:|..| ||.|..||..||..
Human   258 GYDFYGLKDKTWDEVLETHHKLPTDQ----LDLKKQQEAVWELFTSECTYFLDHLLVLKMIFMNT 318

  Fly   454 LERHLNQDELRL------IFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIY-- 510
            | |:|...|..|      :|..:.||......|::.|...:............|||......|
Human   319 L-RYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYFR 382

  Fly   511 -------GEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHL 568
                   ..:|.....||.||..:.:::. ....::.||::....:|.:.::|..|:||:.:|.|
Human   383 GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQRLTRYPL 446

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMI-DVSQYINEVKRDSDHLV----------IIQKV----- 617
            ||..:.|         ||::.|::.|| .:.:.:.:..||.:..|          .:|::
Human   447 LLKNIWK---------RSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEIIVWPP 502

  Fly   618 ---KDS-----ICDIHLLQNGNGSDLLQ--YGRLLLDGELHIKAHEDQKTKLR--YAFVFDKILI 670
               :|.     .|..|:.:.....::|.  ...||.:|:|.:.    :.|:..  |.|:|:..|:
Human   503 LWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLA----ESTRFLDVYLFLFNDFLL 563

  Fly   671 MVKALHIK---------------TGDMQYTYRDS------------HNLADYRVEQSHSRRTIGR 708
            :.|....|               |.::|...::.            ..|....:|..|. ...|.
Human   564 VTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVVKSIEPLHV-SVFGL 627

  Fly   709 DTRF------KYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT 767
            ...|      :|:..:|      ||.|..::|:.:..|...:|.|:.....  .|.| .|:.::|
Human   628 RNAFLIQHENRYRQCIA------AFLLQAQTENIKKTWMAQITTAISCFTK--SQET-KKISLFT 683

  Fly   768 FDAPTT 773
            ..|.::
Human   684 LPAESS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	47/191 (25%)
		PH_Vav	624..753	CDD:269930	29/165 (18%)
		PH	641..749	CDD:278594	27/142 (19%)
		C1_1	761..804	CDD:278556	3/13 (23%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
PLEKHG7	NP_001364258.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		DUF4675	2..178	CDD:406211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..140
		RhoGEF	292..476	CDD:214619	47/194 (24%)
		PH_PLEKHG7	535..663	CDD:270065	25/138 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910