DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and sif

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001261446.1 Gene:sif / 43892 FlyBaseID:FBgn0085447 Length:2734 Species:Drosophila melanogaster


Alignment Length:714 Identity:151/714 - (21%)
Similarity:240/714 - (33%) Gaps:243/714 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 DLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG--------------TEDID 217
            :|..|.|......|::|....:||..|......|..|:..:.:.||              ..|:|
  Fly  1225 ELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVINGAIVSDLD 1289

  Fly   218 -DYI------EDSLSNMCDST------------IDNDAEDAGV------ETPLLSDCQGSHVREL 257
             .|:      |.|||.|..|:            :.:|..|:.|      :.|::|:         
  Fly  1290 MMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTDPPVMSE--------- 1345

  Fly   258 SFDLALDVVSSTTDGAS-NAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRL---VSTSSS 318
            .....|.|.:...:|.| :..:|..||....|....||.|..:.|....|..:|.|   ..||.:
  Fly  1346 EMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVVVGGLGVAKPTSRT 1410

  Fly   319 SSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDN 383
            ||                 :...:.:.:.|.|                   |.::.....||:  
  Fly  1411 SS-----------------FEIENLLKTAEQE-------------------TRKSSPTGSVTS-- 1437

  Fly   384 IACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKT 448
                                   ::..|:.:.:...|..|:...|:.||:|||..|:..|..|..
  Fly  1438 -----------------------SVSTTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLE 1479

  Fly   449 KFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRESLT--------------PNAKVKMA 497
            .::.|::|.  |:..|:..:|..|.|:|....:||..|.|||.              .|....:.
  Fly  1480 HYLEPMKRETFLSNAEINALFGNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIG 1544

  Fly   498 QVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSV---- 558
            ..||.:...|.:|..||          |...|..:::..         |.|...|::.|:.    
  Fly  1545 SAFLYYVNHFKLYSSFC----------ASHSKAQKVLHP---------NEGNHALQEFLAARNPK 1590

  Fly   559 -------------PMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDH 610
                         |:||||||.|||.::...|....|::..|..|.:.|..|:::|||::|    
  Fly  1591 QQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQR---- 1651

  Fly   611 LVIIQKVKDSICDIHLLQNGNGS----------DLLQY------------GRLLLDGELH----- 648
               |.:...:|.| ||.:....|          |||.|            |::....|||     
  Fly  1652 ---IHEEYGAIFD-HLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFV 1712

  Fly   649 --------IKAHEDQKTKL---------------RYAFVFDKILIMVKALHIKTGDMQYTYRDSH 690
                    .|....||.||               ||..:.....:.|:|...|  ||     |||
  Fly  1713 FKSAVVFLCKERLRQKKKLMGVSSKNATNEVEIIRYQVLIPVTEVQVRASSAK--DM-----DSH 1770

  Fly   691 NLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPP 754
                :..|..|.|..:.|.:...|.|..:....:.||   ||:      .|:.:.|::.::..|
  Fly  1771 ----FLWELIHLRSQLQRRSEKVYVLSNSTADFRNAF---LKT------IRQIIRESVRNMSIP 1821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 53/207 (26%)
PH_Vav 624..753 CDD:269930 38/178 (21%)
PH 641..749 CDD:278594 30/135 (22%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
sifNP_001261446.1 WH1 35..144 CDD:214674
PH1_Tiam1_2 860..985 CDD:269937
PH 873..974 CDD:278594
TIAM1_RBD 1141..1219 CDD:176413
PDZ_signaling 1221..1308 CDD:238492 20/82 (24%)
RhoGEF 1456..1647 CDD:238091 52/209 (25%)
PH2_Tiam1_2 1650..1823 CDD:269957 43/200 (22%)
PH 1693..1812 CDD:278594 30/138 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462290
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
32.870

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