DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Shf

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001360940.1	Gene:	Shf / 435684	MGIID:	3613669	Length:	483	Species:	Mus musculus

Alignment Length:	182	Identity:	39/182 - (21%)
Similarity:	63/182 - (34%)	Gaps:	49/182 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   750 SLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQ-NP 813
            |||....|          |:....|....:..|||:....               |.|..|. .|
Mouse   320 SLEDSSAQ----------FEGSENCLSPGREEKGRLPPRL---------------SAGNPKSAKP 359

  Fly   814 VSVPPPVCDRQLSEFN----------WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETM 868
            :.:.|   ...|.|:.          |:.|.:.|..|.:.|...:..:||:|     .|...:..
Mouse   360 LGMEP---SSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVR-----NSETSKND 416

  Fly   869 YALSLKTDDNVIKHMKINQENSGDSMLYCLSSRR-HFKTIVELVSYYERNDL 919
            ::||||:....: |||:::.....   |.|.... .|.::.|:|.:|....|
Mouse   417 FSLSLKSSQGFM-HMKLSRTKEHK---YVLGQNSPPFSSVPEIVHHYASRKL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	2/2 (100%)
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	5/42 (12%)
		SH2_Vav_family	824..934	CDD:198193	25/107 (23%)
		SH3	940..993	CDD:302595
Shf	NP_001360940.1	SH2_SHF	381..478	CDD:198255	23/93 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910