DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and MCF2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_005262470.1	Gene:	MCF2 / 4168	HGNCID:	6940	Length:	1044	Species:	Homo sapiens

Alignment Length:	428	Identity:	92/428 - (21%)
Similarity:	163/428 - (38%)	Gaps:	144/428 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 TTDNIACNGT----------GY------------------DHTNTKEEEVYQDLCALHRTSRSQT 416
            |.:|:..:||          ||                  :.:|.|.|.|..  |...|:|
Human   541 TPENLVTSGTPFFSSKQVGVGYSFFQACKLFSKGKKTWRQNQSNLKIEVVPD--CQEKRSS---- 599

  Fly   417 ASSTSFEQ-------RDYVIRELIDTESNYL----DVLTALKTKFMGP----LERHLNQDELRLI 466
            ..|:|.:.       :::|:.|||.||..|:    .||...:.:...|    |...|.:::..::
Human   600 GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDIL 664

  Fly   467 FPRIRELVDIHTK-FLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKK 530
            |..:.|:.:.|.. ||..|..  ..:|..::...||:.::.|.:|.::|               :
Human   665 FGNMAEIYEFHNDIFLSSLEN--CAHAPERVGPCFLERKDDFQMYAKYC---------------Q 712

  Fly   531 NQIIDQLV----------QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK-----ETSPL 580
            |:...:.:          |:|:|... .:|:|...|..|:|||.||.|||.:|:|     |.|.|
Human   713 NKPRSETIWRKYSECAFFQECQRKLK-HRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSAL 776

  Fly   581 HDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
                  |::|.:||:|:.:.:|    ||.|.:.|              ||...:|.:.|::::.|
Human   777 ------LKKALDAMLDLLKSVN----DSMHQIAI--------------NGYIGNLNELGKMIMQG 817

  Fly   646 ELHI-KAHEDQKTKL----------RYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQ 699
            ...: ..|:...||:          |:.|:::|.::..|.                     |||.
Human   818 GFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKR---------------------RVES 861

  Fly   700 SHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHER 737
            ..     |.|....|......|..:...|.|:|.::.:
Human   862 GE-----GSDRYPSYSFKHCWKMDEVGITEYVKGDNRK 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	50/198 (25%)
		PH_Vav	624..753	CDD:269930	22/125 (18%)
		PH	641..749	CDD:278594	18/108 (17%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
MCF2	XP_005262470.1	SEC14	48..188	CDD:214706
		SPEC	328..519	CDD:238103
		RhoGEF	615..792	CDD:238091	50/200 (25%)
		PH-like	799..930	CDD:302622	23/136 (17%)
		PH	842..927	CDD:278594	14/79 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910