DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and ptpn4b

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_005174003.1 Gene:ptpn4b / 407634 ZFINID:ZDB-GENE-030131-6259 Length:935 Species:Danio rerio


Alignment Length:457 Identity:88/457 - (19%)
Similarity:148/457 - (32%) Gaps:161/457 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 RDYNVGKL-QLRD-----------ILSVPMQ--RILKY---HLLLDKLVKETSPLHDDYRSLERA 590
            |.|:||.| :.|:           :|...:|  |:.|.   .:|||.:.|.......||..|:.|
Zfish    11 RSYDVGALEEARERQHAQVECNVLLLDNTVQTFRVNKQDQGQILLDVVYKHLELTERDYFGLQLA 75

  Fly   591 KEAMIDVSQYIN-------EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDL--LQYGRLLLDGE 646
            .:.. |..::::       ::||.|.|.:.. :||..:.|...||......|  ||..:.:|.|.
Zfish    76 DDTS-DTQRWLDPNKPVRKQLKRPSPHNLRF-RVKFFVGDPGKLQEEYTRYLYFLQLKQDILSGR 138

  Fly   647 LHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADY---------------R 696
            |..    .|.|         .:|:...|:..:.||..::...|..|::|               :
Zfish   139 LPC----PQNT---------AVLLASYAVQAELGDYSHSEHLSGYLSEYSFIPNPPQDFEKEVAK 190

  Fly   697 VEQSHSRRTIGRDTRFKY------------QLLLARKSGKT---------AFTLY---------- 730
            :.|.|:..|..: :.|.|            :|..||....|         ..::|          
Zfish   191 LHQEHNGLTPAQ-SEFNYLNAARTLELYGVELHYARDHCNTEIYVGVLSAGISVYKDRVRVNHFP 254

  Fly   731 --------LKSEHERDKWRKALTEAMESL------------------------------EPPGCQ 757
                    .||:....:.||.|||..|||                              .||   
Zfish   255 WFKIVKISFKSKQFFIQLRKELTECRESLLGFNMMNYRACKNLWKSCVENHTFFRLERPVPP--- 316

  Fly   758 STDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPV---SVPPP 819
              :..:.::.|...:..|:|.:.....:..|..                 |..:|.|   |...|
Zfish   317 --ERNLFLHYFTLGSKFRYCGRTEAQSVQYGKE-----------------RGNKNRVFARSPSKP 362

  Fly   820 VCDRQLSEFNWFAGNMDRETAA-HRLENRRIGTYLL--RVRPQGPSTAHETMYALSLKTDDNVIK 881
            :..|.:|..:|       ||.: :.|.:.|:.|..|  |..|..|..::........:...:.|.
Zfish   363 LVRRLMSGLDW-------ETVSRNSLSDDRLETQSLPNRSPPDSPDHSNSVFTTEGARIRPSSIG 420

  Fly   882 HM 883
            |:
Zfish   421 HL 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 19/83 (23%)
PH_Vav 624..753 CDD:269930 37/214 (17%)
PH 641..749 CDD:278594 29/161 (18%)
C1_1 761..804 CDD:278556 4/42 (10%)
SH2_Vav_family 824..934 CDD:198193 13/63 (21%)
SH3 940..993 CDD:302595
ptpn4bXP_005174003.1 B41 30..222 CDD:214604 42/207 (20%)
FERM_N 33..97 CDD:286467 13/64 (20%)
FERM_B-lobe 122..214 CDD:271216 20/105 (19%)
FERM_C_PTPN4_PTPN3_like 216..310 CDD:270010 15/93 (16%)
FA 325..365 CDD:285894 9/56 (16%)
PDZ_signaling 519..606 CDD:238492
PTPc 662..915 CDD:214550
PTPc 687..914 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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