DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and LRCH4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_002310.2	Gene:	LRCH4 / 4034	HGNCID:	6691	Length:	683	Species:	Homo sapiens

Alignment Length:	73	Identity:	24/73 - (32%)
Similarity:	35/73 - (47%)	Gaps:	11/73 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LAMTLRDGVLLCNLVIHLDPSSL------DPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDA 108
            ||..|..||:||.|...|.|.|:      .|    ..|:::.....||::.||:.| ...|:.:|
Human   560 LAEALASGVILCQLANQLRPRSVPFIHVPSP----AVPKLSALKARKNVESFLEAC-RKMGVPEA 619

  Fly   109 DLFEPTML 116
            ||..|:.|
Human   620 DLCSPSDL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	24/73 (33%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
LRCH4	NP_002310.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		LRR 1	43..64
		leucine-rich repeat	46..69	CDD:275380
		LRR 2	69..90
		leucine-rich repeat	70..92	CDD:275380
		LRR_8	92..148	CDD:290566
		LRR_4	92..131	CDD:289563
		LRR 3	92..114
		leucine-rich repeat	93..115	CDD:275380
		LRR_RI	<103..>245	CDD:238064
		LRR 4	115..136
		leucine-rich repeat	116..131	CDD:275380
		LRR 5	137..158
		LRR_8	138..194	CDD:290566
		leucine-rich repeat	138..160	CDD:275380
		LRR 6	160..182
		leucine-rich repeat	161..183	CDD:275380
		LRR_8	182..239	CDD:290566
		LRR 7	183..205
		leucine-rich repeat	184..204	CDD:275380
		leucine-rich repeat	206..228	CDD:275380
		LRR 8	206..226
		LRR 9	228..249
		leucine-rich repeat	229..247	CDD:275380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..539
		CH	537..627	CDD:278723	23/71 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910