DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Exn

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	197/999 - (19%)
Similarity:	328/999 - (32%)	Gaps:	323/999 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DHKAAQPDAEIRILAMTLRD-GVLLCNLVIHLDPSSLDPR----EFNRKPQMAQFLCSKN----- 91
            ||...:||...|    ...| ||.:.|   |..|....|:    ||.||  ...|:.||.
  Fly  1166 DHGDGEPDLRQR----NYNDSGVDMRN---HRLPKPPPPQNQVYEFVRK--FKDFISSKKSPKGS 1221

  Fly    92 ----------IKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLI 146
                      ..||...|..    |..|::|.|                         ...|:.|
  Fly  1222 QQKLYENTPASTLFYVECSK----RTEDVYENT-------------------------DFGPERI 1257

  Fly   147 GFNLQLSPTERSHSD--EAIYKDLHSTDLNMRKT---SSIDASASSS-----AEYYDRTSQSGSL 201
            .......|..:..:.  .|..|:..|....:||:   ||.|....||     :.:|....: |||
  Fly  1258 PAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPE-GSL 1321

  Fly   202 DENSDITIE---NGTEDIDDYIED----------------------SLSNMCDSTIDNDAED--- 238
            ..   :.:|   :|:.::|....|                      :.:|...:||.....|
  Fly  1322 PA---LPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPP 1383

  Fly   239 -----AGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGA-----SNAVTPTPESYARQSQ---- 289
                 .|.::||..:.:....:..|:.....|....|:||     ...|||||..:...|.
  Fly  1384 PPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAE 1448

  Fly   290 ------SPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTE 348
                  |.::.|:.|.....:.|...|.....||...||..:|......:||.:.:....:.:
  Fly  1449 SGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEA-- 1511

  Fly   349 HEYAYIYSEDDEKVYEDLCYVTFQAKAKPE------VTTDNIACNGTGYDHTNTKE-EEVYQDLC 406
                  :...|.  ||:   :..|||||||      .|...:.....|...|...| .||.....
  Fly  1512 ------HGSSDG--YEE---IGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCI 1565

  Fly   407 ALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERH--------LNQDEL 463
            ....|||.::.....|        |:|.:|::||..|..|:..||    .|        |:..:.
  Fly  1566 LPTLTSRERSLQEAKF--------EIITSEASYLKSLNLLRRHFM----NHNAFLDSSVLSAKDR 1618

  Fly   464 RLIFPRIRELVDIHTKFLDKLRESLTPNAK-VKMAQVFLDFRE-PFLIYGEFCSLLLGAIDYLAD 526
            :.:|..|..:.:...:.|.:|......|.. :.:::...:..| .|.:|..||. ..|.:|....
  Fly  1619 KALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCE-HQGRMDRTLR 1682

  Fly   527 VCKKNQ---IIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH-DDYRS- 586
            ..|:::   ...|.:::.|...:...|.|...|.:|||||.:..||:|.:..:.|||: ::|.|
  Fly  1683 RLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESW 1747

  Fly   587 ---LERAKEAMIDVSQYIN------EVKRDSDHLVIIQKVKD-SICDI----------------- 624
               |...::.:...::..|      |::|.:..|.....|:. :|..:
  Fly  1748 KLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGE 1812

  Fly   625 --HLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLR-YAFVFDKILIMVK------------- 673
              |||..|..:. |.:|:.|              ||:. |||:|..:|::.|
  Fly  1813 LTHLLWRGEDAK-LTFGKRL--------------TKISIYAFLFSDLLLLCKRRGESCFSVFDYC 1862

  Fly   674 ---ALHIKTGDM--QYTYRD-----SHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFT 728
               .|.:..||.  |...:|     ..||....:.::..|:|:        :|:|:
  Fly  1863 PRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTV--------ELVLS--------- 1910

  Fly   729 LYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKM------------EIYTFDAPTTCR------ 775
              ..|..::.:|       ::::.||..::...|:            ..|..|.|...:
  Fly  1911 --CPSVSDQQRW-------LQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDV 1966

  Fly   776 -HCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRE- 838
             :.|:.|....:||.|       :..|.:                         .||.|:...|
  Fly  1967 VNVSRKLPDGWYQGER-------IRDGAV-------------------------GWFPGSYTEEL 1999

  Fly   839 TAAH----RLENRR-----IGTYL 853
            .:||    .|:.|.     ..|||
  Fly  2000 NSAHVRARNLKQRHRLLTFTATYL 2023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	26/114 (23%)
		RhoGEF	428..603	CDD:279015	44/198 (22%)
		PH_Vav	624..753	CDD:269930	28/171 (16%)
		PH	641..749	CDD:278594	22/131 (17%)
		C1_1	761..804	CDD:278556	10/61 (16%)
		SH2_Vav_family	824..934	CDD:198193	11/40 (28%)
		SH3	940..993	CDD:302595
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/194 (23%)
		PH_ephexin	1805..1931	CDD:269929	30/166 (18%)
		SH3_ephexin1_like	1944..1998	CDD:212727	12/85 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910