DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and pex13

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_956939.1	Gene:	pex13 / 393618	ZFINID:	ZDB-GENE-040426-1544	Length:	416	Species:	Danio rerio

Alignment Length:	331	Identity:	57/331 - (17%)
Similarity:	97/331 - (29%)	Gaps:	118/331 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 SNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVY 338
            :..|.|.|....|||..|..::.||   |.:|
Zfish    45 TRVVPPIPPRPVRQSYRPTYSSFPS---SYSP--------------------------------- 73

  Fly   339 NYRSSMASTEHEYAYI-YSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEE--- 399
             |.:||......|:|. |.                            ...|.||:..||.:|
Zfish    74 -YGNSMYGGYSPYSYSGYG----------------------------VGGGLGYNRFNTMDEIPP 109

  Fly   400 ------------EVYQDL-CALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFM 451
                        ..:|.: ..:|..|........:|.......|.::|..:::    :.|:..|.
Zfish   110 SRFVQQAEESSRGAFQSIESIVHAFSSVSMMMDATFSAVYNSFRAVLDVANHF----SRLRIHFT 170

  Fly   452 GPLERHLNQDELRLIFPRIRELV------DIHTKFLDKLRESLTPNA--------------KVKM 496
            ..|........||.::.|::.|:      ::...:.|....|...:|              .||.
Zfish   171 KVLSAFALVRTLRYLYRRLQRLMGLRQGSEVDDLWADSAASSSVVSASGARGAGVEEPGVNSVKS 235

  Fly   497 AQVFLDFR----EPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVG-----KLQL 552
            ..:||.|.    .|:||: ...|...||.:...:......  |.:|.:.|.|:...     .:|.
Zfish   236 WPIFLFFAVVLGGPYLIW-RLLSSAEGAEENATNWASGED--DHVVARVEYDFTAASEEEISVQA 297

  Fly   553 RDILSV 558
            .|:|::
Zfish   298 GDMLNL 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	30/160 (19%)
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
pex13	NP_956939.1	Peroxin-13_N	108..256	CDD:282008	24/152 (16%)
pex13	NP_956939.1	SH3_PEX13_eumet	278..335	CDD:212798	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030