DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Chd64

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_647860.1	Gene:	Chd64 / 38490	FlyBaseID:	FBgn0035499	Length:	188	Species:	Drosophila melanogaster

Alignment Length:	178	Identity:	52/178 - (29%)
Similarity:	82/178 - (46%)	Gaps:	34/178 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASSSSSNSFGGVAG-----VNG----DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRD 56
            |||:.::.|  |.|.     :|.    :|.:|.:.|: :.....|.:.:...|....:    |:|
  Fly     1 MASNRAAKS--GFAAEAQRKINSKYSEELAQESLEWI-KAVTEEPINTSGDTDNFFEV----LKD 58

  Fly    57 GVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTN 121
            ||:||.|...|.|.|:  ::.| :.:|| |.|.:||..|| .|..|||:...:.|:...|::..|
  Fly    59 GVILCKLANALQPGSI--KKIN-ESKMA-FKCMENISAFL-ACAKNFGVPTQETFQSVDLWERQN 118

  Fly   122 FHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTE-----RSHSDEAI 164
            .:.|:|.|..|.  ||....:...||      |.|     |:.|||.:
  Fly   119 LNSVVICLQSLG--RKASNFNKPSIG------PKEADKNVRNFSDEQL 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	34/111 (31%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Chd64	NP_647860.1	CH_SF	22..131	CDD:412120	35/120 (29%)
Chd64	NP_647860.1	Calponin	165..187	CDD:395325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910