Protein Alignment Vav and Lmo7

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_036014595.1
• Gene: Lmo7 / 380928
• MGIID: 1353586
• Length: 1807
• Species: Mus musculus
• Alignment Length: 1121
• Identity: 213/1121 - (19%)
• Similarity: 352/1121 - (31%)
• Gaps: 382/1121 - (34%)

  Fly    13 VAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREF 77
            ||......|.|.|               .:.:.|......:|.:|||||:|:..|.|..:  ::.
Mouse    13 VAFAEAQRWVEAV---------------TEKNFETTDFRASLENGVLLCDLINKLKPGVV--KKI 60

  Fly    78 NRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTN------------FHRVLITLS 130
            ||.......|  .||.:||..| ...|:::|.||.|..|.||:|            ...|||||.
Mouse    61 NRLSTPIAGL--DNINVFLRAC-EQIGLKEAQLFHPGDLQDLSNRVTVKQEETDRRLKNVLITLY 122

  Fly   131 KLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDAS-----ASSSAE 190
            .|.  ||.|. :|...|..|.|...| :...:|:.|.|.  |.:..|.|..|:.     .....|
Mouse   123 WLG--RKAQS-NPYYNGPYLNLKAFE-TLLGQALTKALE--DSSCLKRSGRDSGYGDIWCPDRGE 181

  Fly   191 Y------YDRTSQSGSLDE---------NSDITIENGTE----DID--------DYIEDSLSNMC 228
            :      :.|.....|||.         :||.|:..|.|    |||        ||.:|.:|...
Mouse   182 FPAPPGSHRREDSFESLDSLGSRSLTSCSSDFTLRVGKEGCESDIDWEFTFKMQDYNKDDMSYRR 246

  Fly   229 DSTID-------------NDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
            .|.|:             ...:.:.|..||.......|            ..:....||...|.|
Mouse   247 ISAIEPKSALPFNRFLPNKSKQPSYVPAPLRKKRPDKH------------EDNRRSWASPVYTET 299

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPM--GRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSS 343
            ..:::...:...             ||.|  ...|..:|:||..:..|.::|.|.
Mouse   300 DGTFSSTQRRTW-------------GPKMETWHTVQETSTSSWCVEEEEEKLTRM---------- 341

  Fly   344 MASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDH----------TNTKE 398
                            ..:.:|..||   .|..|.:.:.     |:.:|.          .|.|:
Mouse   342 ----------------PNIVKDDLYV---RKLSPVMPSP-----GSSFDQFLPKCWTPEDMNWKK 382

  Fly   399 ------EEVYQDLCALHRTSRSQTASSTSFE-------------------QRDYVIRELI----- 433
                  :..|::.....|.|.|:...|.||:                   ||..::.||.
Mouse   383 IKRETYKPWYKEFQGFRRNSDSENEDSGSFQSSTIFSRLEKADHRLDSSYQRPSLLLELATKHAM 447

  Fly   434 ---DT-----------ESNYLDVLTALKT---------------KFMGP--LERHLNQD------ 461
               ||           ||:...:|.||:|               ...||  :.|..|:.
Mouse   448 RSRDTHAARRTSSALQESSQFLLLQALQTYSDDILSSETSVKLDPTSGPRLITRRKNRSPAPGYR 512

  Fly   462 ----ELRLIFPR-------IRELVDIHT-----KFLDKLRESLTPNAKVKMAQVFLDFREPFLIY 510
                ||..:.|.       :|:....|.     :..:..|....|:..|: ..:.|..||..|:
Mouse   513 AHDLELPALDPDLENDDFFVRKTGAFHANPCVLRAFEDFRSFSEPDDAVE-RDIILQCREGELV- 575

  Fly   511 GEFCSLLLGAIDYLADVCKKNQIIDQL-VQKCERDYNVGKLQLRDI-----LSVPMQRILKYHLL 569
                         |.|:.|.:.|:.:: .||.|...:....:.:.:     .::|.:...|:..:
Mouse   576 -------------LPDLEKDDMIVRRIPAQKKEVPLSGAPDRYQPVPFPEPWTLPPEIQAKFLSV 627

  Fly   570 LDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKV--------------KDS 620
            |::    |.|      ..|::....:.|..|  ..|:|.   ::.:|:              |..
Mouse   628 LER----TRP------PKEQSSGCRVLVPSY--RQKKDD---MLARKIQSWKLGTAVPPISFKPG 677

  Fly   621 ICDIHLLQNGNG---SDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDM 682
            .|....||....   :..|::.:.|:...|..|.:.:..:|                   ...|:
Mouse   678 PCSEADLQKWEAIWEASRLRHRKRLMVERLFQKIYGENGSK-------------------SMSDV 723

  Fly   683 QYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR-KSGKTAFTLYL-KSEHER-------- 737
              :..|..||...|.|:....::..::...|:|..||: |:.:.::|..| |.:.||
Mouse   724 --SAEDVQNLRQVRYEEMQKIKSQLKEQDQKWQDDLAKWKNRRKSYTSDLQKKKEEREEIEKQAL 786

  Fly   738 ---DKWRKALTEAMESLEPPGCQSTDHKMEIYTFD--------APTTCRHCSKFLKGRIHQGYRC 791
               |:..|...|.::..|..|...|..: ..|:.|        .||.....:.:...|:..
Mouse   787 EKSDRSSKTFREMLQDRESRGSTVTSWR-RTYSSDDILDDGVLPPTVTLSETSYQSERLED---- 846

  Fly   792 KVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMD-----RETAAHRLENRRIGT 851
                            ..:.:|..:|.       .:...||...|     .:.|:|..|.:|:..
Mouse   847 ----------------EARAHPAEMPK-------EDSTTFANREDSVVAETQLASHSPEEQRLAP 888

  Fly   852 YLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSML-------YCLSSRRHFKTIVE 909
            .......|...::.|...|..|.|:.   :...:..|....:.|       ..|||::.:.|..|
Mouse   889 SPSEEPRQASGSSAEPHQAPLLSTEP---RRTPLPSEEPHQASLSSTLQRPSSLSSQQSWSTRAE 950

  Fly   910 -------LVSYYERND 918
                   |...|:|.|
Mouse   951 STRISASLPRSYQRTD 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	35/123 (28%)
		RhoGEF	428..603	CDD:279015	41/238 (17%)
		PH_Vav	624..753	CDD:269930	26/144 (18%)
		PH	641..749	CDD:278594	23/120 (19%)
		C1_1	761..804	CDD:278556	5/50 (10%)
		SH2_Vav_family	824..934	CDD:198193	23/114 (20%)
		SH3	940..993	CDD:302595
Lmo7	XP_036014595.1	CH_LMO7	14..129	CDD:409126	39/136 (29%)
		DUF4757	242..>314	CDD:406382	12/96 (13%)
		DUF4757	655..802	CDD:406382	29/167 (17%)
		fibronec_FbpA	<829..>930	CDD:411474	18/130 (14%)
		PDZ	1114..1183	CDD:238080
		LIM	1738..1796	CDD:259829

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910