DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and RhoGEF3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	189/912 - (20%)
Similarity:	287/912 - (31%)	Gaps:	309/912 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LTNFHRVLITLSKLSQCRKVQQLHPDLIGFN---LQLSPT--------------------ERSHS 160
            |..|.|.|...:..:|.. :..|.|..:|.|   .:.|||                    |...:
  Fly  2653 LQKFKRTLNNFNNKNQLH-ISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTASDPGSEAGDT 2716

  Fly   161 DEAIY----------KDLHSTDLNMR-KTSSIDASAS---SSAEYYDRTSQSGS-LDENSDITIE 210
            ....|          |:...|..|.| |.:|.|:...   ...|.|.|.:.:.| .||.....:.
  Fly  2717 SSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFALT 2781

  Fly   211 NGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQ-GSHV------------------RE 256
            ||:..:      :||.|......|.|:.:.:..|.:...: ..|:                  |.
  Fly  2782 NGSCGV------ALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRS 2840

  Fly   257 LSFDLAL--------DVVSSTTDG-ASN--AVTPTPESYARQSQSPLAAAAPS------------ 298
            ||....|        |:..|.:|. |||  |::..|.:||....: ..|..|.
  Fly  2841 LSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYN-FTAGGPQELGLERGMLIEI 2904

  Fly   299 VPVSAAP------------------GPPMG-------RLVSTSSSSSSLLVSESQRLQRAAAAVY 338
            :.....|                  ||.:|       |::. ...:.:..::.......|||...
  Fly  2905 LRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIH-CPETDNFFIAHRAAADEAAAEEA 2968

  Fly   339 NYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEV----TTDNIACNGTGYDHTNTKEE 399
            ..|:...|.....|....:.|..|..|...||......|..    :.|.:|
  Fly  2969 TARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVA-------------- 3019

  Fly   400 EVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHL---NQD 461
                           |...||..  |...:|||:|||.||:.:|.|:...::..:.:.:   :.:
  Fly  3020 ---------------QPDHSTII--RRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPN 3067

  Fly   462 ELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCS------LLLGA 520
            .:||||..|..:.....|||:.||..:..|   ::|:|||...:.||.|..:|:      :.|..
  Fly  3068 SIRLIFSNITAIYKFQRKFLEALRRGIEQN---QVAKVFLKMHKGFLCYSTYCNAYPRALIELET 3129

  Fly   521 IDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK---------- 575
            .|.:.|.       ..:::.|....|:.:|.|...|..|:|||.:|.|.|::::|
  Fly  3130 YDRVKDA-------RTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEG 3187

  Fly   576 ------ETSPLHDDYRSLE--------------RAKEAMIDVSQYINEVKRDSDHLVIIQKVKDS 620
                  :::....||..|:              .|.|||..:::.:||.||.|:.:...|.
  Fly  3188 NDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQA---- 3248

  Fly   621 ICDIHLLQNGNGSDL-LQYGRLLLDGELHIKAHEDQKTKL---RYA-FVFDKILIMVKALHIKTG 680
                 ..||..|..| |...|..|..:.     ..||..|   .|. |:||..|:..|...||..
  Fly  3249 -----SFQNFKGPPLHLHSARFFLQVDA-----TRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRS 3303

  Fly   681 DMQY------------TYRD----SHNLADYRVEQSHSR--------RTIGRDTRFKYQLLLARK 721
            ...|            ..||    .|.:.:.....|.||        |:..|..||...|.|.|:
  Fly  3304 HFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368

  Fly   722 SGKTAFTLYLKS----EHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFD------------- 769
            .|..|  ||:..    |:..:             |.||..|.....:...|:
  Fly  3369 FGGKA--LYVSEMTGFEYNYE-------------ERPGDYSDQSDYDAQDFELATGVTSGESSLP 3418

  Fly   770 ---APTTCRHCSKFLK-------------------------GRIHQG--YR------CKVCQISV 798
               |.:|.|.|....|                         ||.|.|  :|      |...|...
  Fly  3419 ESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQSPT 3483

  Fly   799 HK 800
            ||
  Fly  3484 HK 3485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	4/12 (33%)
		RhoGEF	428..603	CDD:279015	52/213 (24%)
		PH_Vav	624..753	CDD:269930	37/161 (23%)
		PH	641..749	CDD:278594	31/139 (22%)
		C1_1	761..804	CDD:278556	15/89 (17%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	9/66 (14%)
		RhoGEF	3031..3235	CDD:279015	52/213 (24%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	35/146 (24%)
		PH	<3285..3363	CDD:278594	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940