DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and gek

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_523837.2	Gene:	gek / 37858	FlyBaseID:	FBgn0023081	Length:	1637	Species:	Drosophila melanogaster

Alignment Length:	794	Identity:	154/794 - (19%)
Similarity:	280/794 - (35%)	Gaps:	219/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NNFGIRDADL-----FEPTMLYDLTNFHRVLI------TLSKLSQCRKVQQLHPDLIGF------ 148
            :||.:.|.|:     ..|:.....:.||...|      |.|.....:|.|.     .||
  Fly   395 SNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKNQS-----SGFGDDTLD 454

  Fly   149 -----NLQLSPTERSHS--DEAIYKDLH---------STDLNMRKTSSIDASASSSAEYYDRTSQ 197
                 .|.:.|:..|.:  |....|.|:         ..:|:.:.....:...:..:|..|..||
  Fly   455 TISSPQLAILPSNNSETPVDSVQLKALNDQLAALKQEKAELSKQHNEVFERLKTQDSELQDAISQ 519

  Fly   198 SG-SLDENSDIT----------------IENGTEDIDDYIE--DSLSN---MCDST---IDNDAE 237
            .. ::.|.|::|                :.:..|::|..::  |||.|   ..|.|   ::...|
  Fly   520 RNIAMMEYSEVTEKLSELRNQKQKLSRQVRDKEEELDGAMQKNDSLRNELRKSDKTRRELELHIE 584

  Fly   238 DAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVS 302
            ||.:|.     .:...:||.:.|....:......|:|:..|..|
  Fly   585 DAVIEA-----AKEKKLREHAEDCCRQLQMELRKGSSSVETTMP--------------------- 623

  Fly   303 AAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLC 367
                      :|.||..||.   |.:||:    ..::.:.|...|.|      :.:.|.:.|..
  Fly   624 ----------LSISSEMSSY---EIERLE----LQFSEKLSHQQTRH------NMELEALREQF- 664

  Fly   368 YVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIREL 432
                     .|:...|:|.         |||.:..|:     |...:|..|.|...:....:::.
  Fly   665 ---------SELENANLAL---------TKELQQTQE-----RLKYTQMESITDSAETLLELKKQ 706

  Fly   433 IDTESN-------YLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTP 490
            .|.|.:       .|.....||:|.:..|:  ...||   ||..:|...:..|.:..::.|.:..
  Fly   707 HDLEKSSWFEEKQRLSSEVNLKSKSLKELQ--AEDDE---IFKELRMKREAITLWERQMAEIIQW 766

  Fly   491 NAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADV-CKKNQIIDQLVQKCERDYNVGKLQLRD 554
            .:..|.|:.:|.         ...:.:...::||..| ...|..:|....:..|...:.|::|.:
  Fly   767 VSDEKDARGYLQ---------ALATKMTEELEYLKHVGTFNNNGVDNKNWRNRRSQKLDKMELLN 822

  Fly   555 ILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLV-IIQKVK 618
            :.|...:.|...:::.|:|.:..|.|              |...:.:.:.|:..|.:: ..||.:
  Fly   823 LQSALQREIQAKNMISDELSQTRSDL--------------ISTQKEVRDYKKRYDSILHDFQKKE 873

  Fly   619 DSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD-----KILIMVKALHIK 678
            ..:.|   ||.|.    |:|....|:...|   |     .|..||..|     :|:...::...:
  Fly   874 TELRD---LQKGG----LEYSESFLNKSTH---H-----GLSSAFFRDMSKNSEIIDSAESFGNE 923

  Fly   679 TGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGK--TAFTLYLKSEHERDKWR 741
            :||         |......:..:|      ...|.|:...|.|:.|  ::......|:..|::..
  Fly   924 SGD---------NFTPNFFQSGNS------GMLFNYEPKYAGKNNKDHSSMKEASVSDLSREESD 973

  Fly   742 KALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISST 806
            :.:.|:.:.:  || .:..|:..:.||.:||.|.||:..:.|...||..|::|..:.|..|
  Fly   974 QLVKESQKKV--PG-NTAIHQFLVRTFSSPTKCNHCTSLMVGLTRQGVVCEICGFACHTIC---- 1031

  Fly   807 GRCKQNPVSVPPPV 820
              |::.|.:.|.|:
  Fly  1032 --CQKVPTTCPVPM 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	10/41 (24%)
		RhoGEF	428..603	CDD:279015	32/182 (18%)
		PH_Vav	624..753	CDD:269930	25/135 (19%)
		PH	641..749	CDD:278594	20/114 (18%)
		C1_1	761..804	CDD:278556	15/42 (36%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
gek	NP_523837.2	STKc_DMPK_like	98..430	CDD:270748	8/34 (24%)
		S_TKc	100..369	CDD:214567
		KELK	478..556	CDD:292424	11/77 (14%)
		CEP63	492..749	CDD:293650	63/334 (19%)
		CEP63	652..880	CDD:293650	51/288 (18%)
		C1_1	990..1040	CDD:278556	17/55 (31%)
		PH_MRCK	1049..1182	CDD:269949
		CNH	1211..1486	CDD:279162
		CRIB	1544..1580	CDD:238077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910