DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and GEFmeso

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_788403.2	Gene:	GEFmeso / 37134	FlyBaseID:	FBgn0050115	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	136/580 - (23%)
Similarity:	216/580 - (37%)	Gaps:	150/580 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 AEYYDR--TSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQG 251
            |::.:|  .:..|.||..:::........::..:..|.|..|.|||        ..:|||
  Fly   368 AQHMERLTLADPGDLDPRAELIEAVNKTLVNKPLVRSSSAACASTI--------CSSPLL----- 419

  Fly   252 SHVRELSFDLALDVVSSTTDGASNAVTPTPESYA------RQSQSPLAAAAPSVPVSAAPGPPMG 310
            ::.|..|    |...:||..|......||.|..|      :.|...|.......|..||....:.
  Fly   420 TYARTKS----LGAKASTLGGGVPIKLPTAEQLAELEEANKLSAESLDRLTDIKPKFAARLSELA 480

  Fly   311 RL----------VSTSSSSSSLLVSESQRLQRAAAAVYNYRS---SMASTEHEYAYIYSEDDEKV 362
            ||          .|||||||    |.|.:|........:|.:   |:|.:|:|....:......|
  Fly   481 RLNNRPLSSSSICSTSSSSS----SGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSV 541

  Fly   363 YEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDY 427
            .|..|.
  Fly   542 LEKTCL----------------------------------------------------------- 547

  Fly   428 VIRELIDTESNYL-DVLTALKTKFMGPLERH-LNQDELRLIFPRIRELVDIHTKFLDKLRESLTP 490
               |::|:|.::: |:...:|.......||. |..|||:::|..|.|:.:.::..|.:|..  |.
  Fly   548 ---EIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLIN--TG 607

  Fly   491 NAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL--VQKCERDYNVGKLQLR 553
            ....::|:.|:|.|:.|.:|..:|:....||..|..:.:.......|  .||..:.    :|.|.
  Fly   608 RDPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATHTYSLLASTQKLLQH----RLPLG 668

  Fly   554 DILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVK 618
            ..|..|:|||||||||||.|.|     |.|.:.:..|...|..|:..|::|||..:....::::.
  Fly   669 SYLLKPVQRILKYHLLLDSLRK-----HCDVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELS 728

  Fly   619 DSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQ 683
            .      :|....|.:|...|.|..:|.|     .:|..|.|...:|..:||:.|  ..:.|.:|
  Fly   729 G------ILDGWLGPELTVLGELRQEGLL-----MEQHNKQRLVLLFATMLIITK--QKEDGRLQ 780

  Fly   684 Y-TYRDSHNLADYRVEQSHSRRTIGRDTRF--------KYQL-LLAR-KSGKTAFTLYLK 732
            : ||...:||       ..|....|..|.|        ::|: |.|| :..|..:|.::|
  Fly   781 FKTYISQNNL-------MLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	53/178 (30%)
		PH_Vav	624..753	CDD:269930	31/120 (26%)
		PH	641..749	CDD:278594	27/103 (26%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
GEFmeso	NP_788403.2	RhoGEF	548..713	CDD:279015	53/175 (30%)
GEFmeso	NP_788403.2	PH_PLEKHG1_G2_G3	694..839	CDD:270063	38/160 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870