DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and POSH

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_523776.1	Gene:	POSH / 36990	FlyBaseID:	FBgn0040294	Length:	838	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	60/269 - (22%)
Similarity:	102/269 - (37%)	Gaps:	77/269 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 TTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMD 836
            |.||.|.:.:....|: .||..|:|.|         .||.:  .:||.|...::.|      .|.
  Fly    31 TFCRKCLQDIVASQHK-LRCPECRILV---------SCKID--ELPPNVLLMRILE------GMK 77

  Fly   837 RETAAHRLENR--RIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLS 899
            :..||.:.|.:  ...|...|.:||.|        |.|:...||.:..::.:|::...:.   ..
  Fly    78 QNAAAGKGEEKGEETETQPERAKPQPP--------AESVAPPDNQLLQLQSHQQSHQPAR---HK 131

  Fly   900 SRR----HFKTIVELVS------YYERNDL-----------------GE------NFAGLNQSLQ 931
            .||    |...:.:..|      .:::.||                 |:      |:..::..|.
  Fly   132 QRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSVPLP 196

  Fly   932 WPYKEVIATALYDYEPKAGSNQ----LQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQ 992
            .|.    ..|:||:  |.|.|.    |:.:....:.|:.:  ....|..|:||.|:|.||..:|
  Fly   197 MPQ----CIAMYDF--KMGPNDEEGCLEFKKSTVIQVMRR--VDHNWAEGRIGQTIGIFPIAFV- 252

  Fly   993 EQKLASEEL 1001
            |...|:::|
  Fly   253 ELNAAAKKL 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	10/31 (32%)
		SH2_Vav_family	824..934	CDD:198193	24/144 (17%)
		SH3	940..993	CDD:302595	17/56 (30%)
POSH	NP_523776.1	RING	11..53	CDD:238093	7/22 (32%)
		SH3	139..191	CDD:302595	6/51 (12%)
		SH3_SH3RF_2	199..251	CDD:212721	16/59 (27%)
		SH3_SH3RF_3	424..477	CDD:212717
		SH3_SH3RF_C	782..836	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910