DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and triob

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009290354.2	Gene:	triob / 368847	ZFINID:	ZDB-GENE-030616-399	Length:	3023	Species:	Danio rerio

Alignment Length:	693	Identity:	149/693 - (21%)
Similarity:	246/693 - (35%)	Gaps:	187/693 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPRE-FNRKPQMAQFLCSKNIKL 94
            |.|...|...||..         |....:||   |....||::... ||.|..
Zfish  1675 CLVRTTDRSPAQEG---------LVPSAMLC---IDHSRSSMEMEGIFNHKDT------------ 1715

  Fly    95 FLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSH 159
             |.|..|..||..:...:|:.|.......|...||.|                  ...||..|..
Zfish  1716 -LSVSSNEGGISGSATLQPSHLQSSPGPKRPGNTLRK------------------WLTSPVRRLS 1761

  Fly   160 SDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSL 224
            |.:|   |.|...|..:...|.|.          |.:..|...::||               ||.
Zfish  1762 SGKA---DGHVKKLAHKHKKSRDV----------RKNADGGSQKDSD---------------DSA 1798

  Fly   225 SNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTP-----ESY 284
            :...|.||:....:.|:.:..||....|.::....:       ...:|..:...|.|     .|.
Zfish  1799 ATPQDETIEERMRNEGLSSGTLSKSSSSGMQSCGEE-------EGEEGPDSVPLPPPMAIQQHSL 1856

  Fly   285 ARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEH 349
            ..|......||..|           ||..|:.:.|::.|||..:.|.::...:.: |.|....||
Zfish  1857 LHQDSQEDKAARLS-----------GRPSSSETPSAAELVSAIEELVKSKMNLED-RPSSLPVEH 1909

  Fly   350 EYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRS 414
            .                             .:.:.:||.:  |::.........::
Zfish  1910 R-----------------------------DSTSPSCNPS--DNSLLSSSSPIDEM--------- 1934

  Fly   415 QTASSTSF-EQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDEL----RLIFPRIRELV 474
             ....|.| ::|.||:.||::||.:|:..|.|:...:|..::.....|::    :::|..|.::.
Zfish  1935 -DERKTGFLKRRHYVLLELVETERDYVRDLGAVVEGYMSRMKEEGVPDDMKGKDKIVFGNIHQIF 1998

  Fly   475 DIHTKF----LDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIID 535
            |.|..|    |:|..|.  |:   ::|.:|:.......:|          |.|..:..|...|:.
Zfish  1999 DWHKDFFLAELEKCLED--PD---RLAPLFVRQERRLHMY----------IVYCQNKPKSEHIVS 2048

  Fly   536 QLVQKCERD--YNVG-KLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDV 597
            :.:.....|  ..:| :||:.|:|..|:|||:||.|||..|:|.|.....|...||:|.|.|..|
Zfish  2049 EYIDTYFEDLKQRLGHRLQITDLLIKPVQRIMKYQLLLKDLLKFTKKAGLDTVDLEKAVEVMCVV 2113

  Fly   598 SQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHED---QKTKL 659
            .:..|:                 :.::..||..:|..:.| |||||.....:...:.   .:.|.
Zfish  2114 PKRCND-----------------MMNVGRLQGFDGKIVAQ-GRLLLQDTFMVSDQDGGLLSRLKE 2160

  Fly   660 RYAFVFDKILIMVKALHIKTGDMQ--YTYRDSHNLADYRVEQS 700
            |..|:|::|:|..:.|..|.|...  |.:::|..::...:|:|
Zfish  2161 RRIFLFEQIVIFSEPLDKKKGFSMPGYLFKNSIKVSWLGLEES 2203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	24/101 (24%)
		RhoGEF	428..603	CDD:279015	51/185 (28%)
		PH_Vav	624..753	CDD:269930	22/82 (27%)
		PH	641..749	CDD:278594	16/65 (25%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
triob	XP_009290354.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910