DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Arhgef12

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001013264.2	Gene:	Arhgef12 / 367072	RGDID:	1305111	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	140/683 - (20%)
Similarity:	245/683 - (35%)	Gaps:	185/683 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GFNLQLSPTER--SHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYD--RTSQSGSLDENSDI 207
            ||...|.|..|  .|.:.||.:.:....|  |....:.|.:|.|.|..|  :..|||
  Rat   596 GFPSILGPPRRPSRHDNSAIGRAMEIQKL--RHPKHLSAPSSMSPELQDPAKLRQSG-------- 650

  Fly   208 TIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDG 272
                                    :.|:..|.|.                   |....:||.|.|
  Rat   651 ------------------------VANEGTDTGY-------------------LPASSMSSATSG 672

  Fly   273 ASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAV 337
            |:     ..:...|::.:    .|..|..:.|||..:                  ..:.|....|
  Rat   673 AA-----LSQEGGRENDT----GAKQVGDAVAPGDCL------------------DSIPRVPNTV 710

  Fly   338 YNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAK---AKPEVTTDNIACNGTGYDHTNTKEE 399
            :::...:.              ::|.|:.|.|...|:   .||....|:||     :..:.:::|
  Rat   711 FDFPPPLL--------------DQVQEEECEVERVAEHGTPKPFRKFDSIA-----FGESQSEDE 756

  Fly   400 EVYQDLCALHRTSRSQTASSTSFE----------QRDYVIRELIDTESNYLDVLTALKTKFMGPL 454
            :...||    .|.........|.|          :|..||.||..||..::..|..|...|...:
  Rat   757 QFENDL----ETDPPNWQQLVSREVLLGLKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRV 817

  Fly   455 ERH--LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIY----GE- 512
            .|.  |:..|||.||..:.:::.:|.    .|.|.:....|.....|.....|..|::    ||
  Rat   818 SREGILSPSELRKIFSNLEDILQLHV----GLNEQMKAVRKRNETSVIDHIGEDLLLWFSGPGEE 878

  Fly   513 --------FCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLL 569
                    |||....|::.:....||:......||..|.:....:|||:||:...|||:.||.||
  Rat   879 KLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLL 943

  Fly   570 LDKLVKETS-PLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKD-----SICDIHLLQ 628
            ||.:.|.|. |  .:...:::|.:....:..|:|:..|::::.   |:::|     ....:.|.:
  Rat   944 LDNIAKYTEWP--PEREKVKKAADQCRQILNYVNQAVREAENK---QRLEDYQRRLDTSSLKLSE 1003

  Fly   629 NGNGSDL----LQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILI--------MVKALHIK--- 678
            ..|..:|    |...:::.:|.|..|.:.|:...| |..:.:.||:        :|...|.|
  Rat  1004 YPNVDELRNLDLTKRKMIHEGPLVWKVNRDKSIDL-YTLLLEDILVLLQKQDDRLVLRCHSKILA 1067

  Fly   679 -TGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRK 742
             |.|.::|:.....|:...|.|      :..|.:..:.:.:: .:|...:.|..::..|:..|:.
  Rat  1068 STADSKHTFSPVIKLSTVLVRQ------VATDNKALFVISMS-DNGAQIYELVAQTVSEKTVWQD 1125

  Fly   743 ALTEAMESL-----------EPPGCQSTDHKME 764
            .:.....|:           :||.|:..:.:.|
  Rat  1126 LICRMAASVKEQSTKPIPLPQPPPCEGDNDEEE 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	53/190 (28%)
		PH_Vav	624..753	CDD:269930	27/155 (17%)
		PH	641..749	CDD:278594	22/119 (18%)
		C1_1	761..804	CDD:278556	1/4 (25%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Arhgef12	NP_001013264.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910