DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Arhgef6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_008771873.1	Gene:	Arhgef6 / 363509	RGDID:	1359674	Length:	789	Species:	Rattus norvegicus

Alignment Length:	999	Identity:	190/999 - (19%)
Similarity:	323/999 - (32%)	Gaps:	379/999 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLC 88
            |.||....|: .|......|:   ..|..:|::||:||.|:..|.|.|::  ::.::|| .:..|
  Rat    32 VTWLISLGVLESPKKTICDPE---EFLKSSLKNGVVLCKLISRLLPGSVE--KYCQEPQ-TEADC 90

  Fly    89 SKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLS 153
            ..||..||..|    .....::|||..||...||.:||.||..:::..:.|          |...
  Rat    91 IDNINDFLKGC----ATLQVEVFEPDDLYSGANFSKVLNTLLAVNKATEDQ----------LSER 141

  Fly   154 PTERSHSDEAIYKDLHSTDLNMRKTSSIDASASS----SAEYYDRTSQSGSLDENSDITIENGTE 214
            |..||                    ||:.|:.||    .|.....|.:..|.::.:::| |||:.
  Rat   142 PCGRS--------------------SSLSATTSSQTNPQAAVPSTTPEQQSEEKAAEMT-ENGSH 185

  Fly   215 DIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT-------DG 272
            .:   |..:..|...:..|.           ||.|:|            |::..|.       :|
  Rat   186 QL---IVKARFNFKQTNEDE-----------LSVCKG------------DIIYVTRVEEGGWWEG 224

  Fly   273 ASNAVTP-TPESYARQ---SQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRA 333
            ..|..|. .|.:|.|:   |:.||:..|..
  Rat   225 TLNGRTGWFPSNYVREIKPSERPLSPKAVK----------------------------------- 254

  Fly   334 AAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKE 398
                                                                    |:|
  Rat   255 --------------------------------------------------------GFD------ 257

  Fly   399 EEVYQDLCALHRTSRSQTASSTSFEQRDY---VIRELIDTESNYLDVLTALKTKFMGPLE--RHL 458
                             ||..|    ::|   |::.::|||..|...|.:|...::.||:  .:|
  Rat   258 -----------------TAPLT----KNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNL 301

  Fly   459 NQDELRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLD----FREPFLIYGEFCSLLL 518
            :..|...:.....|:..........|.| |.:|..:.|:....|:    |:..:|.|   |:...
  Rat   302 STVEFTCLLGNFEEVCTFQQTLCQALEECSKSPENQHKVGGCLLNLMPHFKSMYLAY---CANHP 363

  Fly   519 GAIDYLADVCKKNQIIDQLVQKCERD--YNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH 581
            .|::.|      .|..|.|.:..|..  .:.|.|.|...||.|..|:.||..||.:|.:.....|
  Rat   364 SAVNVL------TQHSDDLERFMENQGASSPGILILTTSLSKPFMRLEKYVTLLQELERHMEDTH 422

  Fly   582 DDYRSLERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
            .|::.:.:|..|...:.....:: ||....|.|:.:.         :|...|.|:...|.::...
  Rat   423 PDHQDILKAIIAFKSLMGQCQDLRKRKQLELQILSEP---------IQAWEGDDIKTLGNVIFMS 478

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADY---RVEQSHSRRTIG 707
            ::.::....::.:.||..:|..:|||:.|....:|   :.|:....:|..   |:::..     |
  Rat   479 QVVMQHGACEEKEERYFLLFSSVLIMLSASPRMSG---FMYQGKVPIAGMVVTRLDEIE-----G 535

  Fly   708 RDTRFKYQLLLARKSGKTAFTLYLKSEHERD--KWRKALTEAMESLEPPGCQSTDHKMEIYTFDA 770
            .|..|:.       :|.|...:.:...:.:|  :|.:.|....:.  |..|.|.          :
  Rat   536 NDCTFEI-------TGSTVERIVVHCNNNQDFQEWMEQLNRLTKG--PASCSSL----------S 581

  Fly   771 PTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVP--------------PPV- 820
            .|:...||      .|..:              ||||: .:.|:..|              ||:
  Rat   582 KTSSSSCS------THSSF--------------SSTGQ-PRGPLEPPQIIKPWSLSCLRPAPPLR 625

  Fly   821 --------------------------CDRQLSEFNWFAGNMDRETAAHRLENRRI---------- 849
                                      .:|:.||..:    :.|::.|...|:.:|
  Rat   626 PSAALGYKEESSKSPKTMKKFLHKRKTERKTSEEEY----VIRKSTAALEEDAQILKVIEAYCTS 686

  Fly   850 -----GT----------------YLLRVRPQGPSTAHE-----TMYALSLKTDDNVIKHMKINQE 888
                 ||                .:...|..|.:...|     |:|||.     :.:|.:|  ||
  Rat   687 ASFQQGTRKDSVPQVLLPEEEKLIIEETRSNGQTIIEEKSLVDTVYALK-----DEVKELK--QE 744

  Fly   889 NSGDSMLYC----LSSRRHFKTIV 908
            |.  .|..|    |.||:..:.:|
  Rat   745 NK--KMKQCLEEELKSRKDLEKLV 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	35/107 (33%)
		RhoGEF	428..603	CDD:279015	44/183 (24%)
		PH_Vav	624..753	CDD:269930	23/133 (17%)
		PH	641..749	CDD:278594	19/112 (17%)
		C1_1	761..804	CDD:278556	4/42 (10%)
		SH2_Vav_family	824..934	CDD:198193	26/125 (21%)
		SH3	940..993	CDD:302595
Arhgef6	XP_008771873.1	CH	29..129	CDD:214479	35/106 (33%)
		RhoGEF67_u1	139..184	CDD:293221	14/65 (22%)
		SH3_alphaPIX	186..242	CDD:212993	15/81 (19%)
		RhoGEF	266..443	CDD:238091	44/185 (24%)
		PH_Cool_Pix	474..572	CDD:269932	19/112 (17%)
		PH	491..572	CDD:278594	19/95 (20%)
		RhoGEF67_u2	598..691	CDD:293220	12/97 (12%)
		betaPIX_CC	694..780	CDD:293131	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910