Protein Alignment Vav and Arhgef6

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_008771873.1
• Gene: Arhgef6 / 363509
• RGDID: 1359674
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 999
• Identity: 190/999 - (19%)
• Similarity: 323/999 - (32%)
• Gaps: 379/999 - (37%)

  Fly    25 VAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLC 88
            |.||....|: .|......|:   ..|..:|::||:||.|:..|.|.|::  ::.::|| .:..|
  Rat    32 VTWLISLGVLESPKKTICDPE---EFLKSSLKNGVVLCKLISRLLPGSVE--KYCQEPQ-TEADC 90

  Fly    89 SKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLS 153
            ..||..||..|    .....::|||..||...||.:||.||..:::..:.|          |...
  Rat    91 IDNINDFLKGC----ATLQVEVFEPDDLYSGANFSKVLNTLLAVNKATEDQ----------LSER 141

  Fly   154 PTERSHSDEAIYKDLHSTDLNMRKTSSIDASASS----SAEYYDRTSQSGSLDENSDITIENGTE 214
            |..||                    ||:.|:.||    .|.....|.:..|.::.:::| |||:.
  Rat   142 PCGRS--------------------SSLSATTSSQTNPQAAVPSTTPEQQSEEKAAEMT-ENGSH 185

  Fly   215 DIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT-------DG 272
            .:   |..:..|...:..|.           ||.|:|            |::..|.       :|
  Rat   186 QL---IVKARFNFKQTNEDE-----------LSVCKG------------DIIYVTRVEEGGWWEG 224

  Fly   273 ASNAVTP-TPESYARQ---SQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRA 333
            ..|..|. .|.:|.|:   |:.||:..|..
  Rat   225 TLNGRTGWFPSNYVREIKPSERPLSPKAVK----------------------------------- 254

  Fly   334 AAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKE 398
                                                                    |:|
  Rat   255 --------------------------------------------------------GFD------ 257

  Fly   399 EEVYQDLCALHRTSRSQTASSTSFEQRDY---VIRELIDTESNYLDVLTALKTKFMGPLE--RHL 458
                             ||..|    ::|   |::.::|||..|...|.:|...::.||:  .:|
  Rat   258 -----------------TAPLT----KNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNL 301

  Fly   459 NQDELRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLD----FREPFLIYGEFCSLLL 518
            :..|...:.....|:..........|.| |.:|..:.|:....|:    |:..:|.|   |:...
  Rat   302 STVEFTCLLGNFEEVCTFQQTLCQALEECSKSPENQHKVGGCLLNLMPHFKSMYLAY---CANHP 363

  Fly   519 GAIDYLADVCKKNQIIDQLVQKCERD--YNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH 581
            .|::.|      .|..|.|.:..|..  .:.|.|.|...||.|..|:.||..||.:|.:.....|
  Rat   364 SAVNVL------TQHSDDLERFMENQGASSPGILILTTSLSKPFMRLEKYVTLLQELERHMEDTH 422

  Fly   582 DDYRSLERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
            .|::.:.:|..|...:.....:: ||....|.|:.:.         :|...|.|:...|.::...
  Rat   423 PDHQDILKAIIAFKSLMGQCQDLRKRKQLELQILSEP---------IQAWEGDDIKTLGNVIFMS 478

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADY---RVEQSHSRRTIG 707
            ::.::....::.:.||..:|..:|||:.|....:|   :.|:....:|..   |:::..     |
  Rat   479 QVVMQHGACEEKEERYFLLFSSVLIMLSASPRMSG---FMYQGKVPIAGMVVTRLDEIE-----G 535

  Fly   708 RDTRFKYQLLLARKSGKTAFTLYLKSEHERD--KWRKALTEAMESLEPPGCQSTDHKMEIYTFDA 770
            .|..|:.       :|.|...:.:...:.:|  :|.:.|....:.  |..|.|.          :
  Rat   536 NDCTFEI-------TGSTVERIVVHCNNNQDFQEWMEQLNRLTKG--PASCSSL----------S 581

  Fly   771 PTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVP--------------PPV- 820
            .|:...||      .|..:              ||||: .:.|:..|              ||:
  Rat   582 KTSSSSCS------THSSF--------------SSTGQ-PRGPLEPPQIIKPWSLSCLRPAPPLR 625

  Fly   821 --------------------------CDRQLSEFNWFAGNMDRETAAHRLENRRI---------- 849
                                      .:|:.||..:    :.|::.|...|:.:|
  Rat   626 PSAALGYKEESSKSPKTMKKFLHKRKTERKTSEEEY----VIRKSTAALEEDAQILKVIEAYCTS 686

  Fly   850 -----GT----------------YLLRVRPQGPSTAHE-----TMYALSLKTDDNVIKHMKINQE 888
                 ||                .:...|..|.:...|     |:|||.     :.:|.:|  ||
  Rat   687 ASFQQGTRKDSVPQVLLPEEEKLIIEETRSNGQTIIEEKSLVDTVYALK-----DEVKELK--QE 744

  Fly   889 NSGDSMLYC----LSSRRHFKTIV 908
            |.  .|..|    |.||:..:.:|
  Rat   745 NK--KMKQCLEEELKSRKDLEKLV 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	35/110 (32%)
		RhoGEF	428..602	CDD:459876	44/182 (24%)
		PH_Vav	624..753	CDD:269930	23/133 (17%)
		C1_VAV	759..810	CDD:410360	8/50 (16%)
		SH2_Vav_family	824..934	CDD:198193	26/125 (21%)
		SH3	940..993	CDD:473055
Arhgef6	XP_008771873.1	CH_alphaPIX	25..141	CDD:409114	37/128 (29%)
		RhoGEF67_u1	139..184	CDD:465201	14/65 (22%)
		SH3_alphaPIX	186..242	CDD:212993	15/81 (19%)
		RhoGEF	266..443	CDD:238091	44/185 (24%)
		PH_Cool_Pix	474..572	CDD:269932	19/112 (17%)
		RhoGEF67_u2	600..691	CDD:465200	11/94 (12%)
		betaPIX_CC	698..782	CDD:465158	18/78 (23%)