DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Stac3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001124030.1	Gene:	Stac3 / 362895	RGDID:	1308964	Length:	361	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	61/288 - (21%)
Similarity:	102/288 - (35%)	Gaps:	65/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 GKTAFTLYLKSEHERDKWRKALTEAMESLEPPG-CQSTDHKMEIYTFDAPTTCRHCSKFLKGRIH 786
            |...:.:|.:.|.|.:       |.....|||. .....||.:.:.|..|..|..|::.:.....
  Rat    57 GGPIYYIYEEEEEEEE-------EEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNK 114

  Fly   787 QGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHR----LENR 847
            .|.|||.|:.::|:.|.|...  .|......||...|..|...:........:||:|    .|..
  Rat   115 FGLRCKNCKTNIHEHCQSYVE--MQKCFGKIPPGFHRAYSSPLYSNQQYACVSAANRNDPVFETL 177

  Fly   848 RIGTYLL-RVRPQGPSTAHETMYAL-----------SLKTDD--NVIKHMKINQENSGDSMLYCL 898
            |:|..:. :.|.:|.:.....:.|:           ..|:.|  :..|..|..::...|......
  Rat   178 RVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQDGNDAEKDKKAEKKTPDDKNKQPG 242

  Fly   899 SSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVL 963
            ..:.|:...:......|::||                        |:.|..           ::.
  Rat   243 FQQSHYFVALYRFKALEKDDL------------------------DFPPGE-----------KIT 272

  Fly   964 VIGKDGDSKGWWRGKIGDTVGYFPKEYV 991
            ||  |..::.|||||||:.||:||..::
  Rat   273 VI--DDSNEEWWRGKIGEKVGFFPPNFI 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	5/29 (17%)
		PH	641..749	CDD:278594	5/25 (20%)
		C1_1	761..804	CDD:278556	13/42 (31%)
		SH2_Vav_family	824..934	CDD:198193	19/127 (15%)
		SH3	940..993	CDD:302595	16/52 (31%)
Stac3	NP_001124030.1	C1_1	89..134	CDD:278556	14/44 (32%)
		STAC2_u1	146..>218	CDD:293269	12/71 (17%)
		SH3_Stac3_1	248..300	CDD:212919	19/88 (22%)
		SH3_Stac_2	307..357	CDD:212768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910