DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Ect2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001102017.2	Gene:	Ect2 / 361921	RGDID:	1308524	Length:	913	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	124/534 - (23%)
Similarity:	201/534 - (37%)	Gaps:	134/534 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 SSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVT 380
            |.|..||....|.|.:|      ..:.|:|....|             .||.  .|..:.:|  :
  Rat   365 SVSLLSLSTPNSNRKRR------RLKESLAQLSRE-------------TDLS--PFPPRKRP--S 406

  Fly   381 TDNIACNGTGYDHTNTKEEEVY----QDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLD 441
            .::....|:..|.:||.:..::    ...||  ::|||.|........|..|.:||..|||||::
  Rat   407 AEHSLSIGSLLDISNTPDSSIHYGETPKSCA--KSSRSSTPVPPKQSARWQVAKELYQTESNYVN 469

  Fly   442 VLTALKTKFMGPLERH-------LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPN--AKVKMA 497
            :|..:...|..|||..       |..:|::.||..|.::.|:|.|..|.| |.|..|  ....:.
  Rat   470 ILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHMKIKDDL-EDLIANWDESRSIG 533

  Fly   498 QVFLDFRE-------PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDY---------- 545
            .:||.:.:       ||:.:.|.               .|..||     |||:..
  Rat   534 DIFLKYSKDLVKTYPPFVNFFEM---------------SKEMII-----KCEKQKPRFHAFLKIN 578

  Fly   546 ----NVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR 606
                ..|:..|.::|..|:||:....|||:.|.|.|:..:.|..:||:|..::.:|..:|||.||
  Rat   579 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKR 643

  Fly   607 DSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLD-------GELHIKAHEDQKTKLRYAFV 664
            .::       .:..|.|:....:|..::||...|.|:.       || |.....:|.|    .|:
  Rat   644 KTE-------AQKQIFDVVYEVDGCPANLLSSHRSLIQRVETVSLGE-HPCDRGEQVT----LFL 696

  Fly   665 FDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSH--------------SRRTIGRDTRFKYQ 715
            |:..|.:.:..|...|    |:|..|:.........|              .|.|  .|....:.
  Rat   697 FNDCLEIARKRHKVIG----TFRSPHDRTRPPASLKHIHLMPLSQIKKVLDIRET--EDCHNAFA 755

  Fly   716 LLL--ARKSGKTAFTLYLKSEH-ERDKWRKALTEAMESLEPPGCQS--------TD-HKMEIYTF 768
            ||:  ..:......:..:.||. .::.|.|.|...:.:..   |::        || ...|:.|.
  Rat   756 LLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTI---CKADAENLMYVTDPESFEVNTK 817

  Fly   769 DAPTTCRHCSKFLK 782
            |..:|....|:.:|
  Rat   818 DMDSTLSRASRAIK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	55/204 (27%)
		PH_Vav	624..753	CDD:269930	29/152 (19%)
		PH	641..749	CDD:278594	25/131 (19%)
		C1_1	761..804	CDD:278556	6/22 (27%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Ect2	NP_001102017.2	PTCB-BRCT	179..242	CDD:289507
		BRCT	266..341	CDD:278934
		RhoGEF	456..640	CDD:279015	55/204 (27%)
		PH_Ect2	631..804	CDD:269936	38/193 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910