Protein Alignment Vav and Fgd3

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_008769765.1
• Gene: Fgd3 / 361223
• RGDID: 1311725
• Length: 733
• Species: Rattus norvegicus
• Alignment Length: 610
• Identity: 119/610 - (19%)
• Similarity: 233/610 - (38%)
• Gaps: 139/610 - (22%)

  Fly   278 TPTPESYARQSQSPLAA------AAPSVPVSAAP---GPPMGRLVSTSSSSSSLL--VSESQRLQ 331
            :|||:   .::.|||..      ::|...:.|.|   |.|.|...|::|:..|.|  .|.:.::.
  Rat     7 SPTPQ---EEAISPLGVPDAGLRSSPLGKLQALPFGSGAPQGAQGSSASAGDSSLGEPSGAMKIP 68

  Fly   332 RAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIA---------CN 387
            ...:.:.:..||:||....     .|:..:.......:...    |||..|:.|         .:
  Rat    69 NRDSGIESPSSSVASENFP-----CEEGSEGSPSPAILGLH----PEVAVDSRAPQDNPQEGEDS 124

  Fly   388 GTGYDHTNTK------EEEVYQDLCA-----LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLD 441
            |.|.| .:.|      ||:|....|:     ||                  :.:||:.||..|:.
  Rat   125 GVGED-PDPKITPCRPEEDVGSTQCSDPQKLLH------------------IAQELLHTEEAYVK 170

  Fly   442 VLTALKTKFMGPL-ERHLNQDELRLIFPRIRELVDIHTKF-LDKLRESLTP--NAKVKMAQVFLD 502
            .|..|...|...| |..:..:....||..|..:...|.:| |..|::.:|.  :.|.::..: |.
  Rat   171 RLHLLDQVFCAKLTEAGIPPEVTTGIFSNISSIYRFHGQFLLPGLKKRITEEWDTKPRLGDI-LQ 234

  Fly   503 FREPFL-IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKY 566
            ...||| :|||:......|:..::...:::.....::...::....|.|.|:..:..|:||:.:|
  Rat   235 KLAPFLKMYGEYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRY 299

  Fly   567 HLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGN 631
            .|||...:|.......|.:..||:.|.:...:.:.|...|..:.:..:.:|.:        |.|.
  Rat   300 ELLLKDYLKRLPRDAPDRKDAERSLELISIAADHSNAAIRKMEKMHKLLEVYE--------QLGG 356

  Fly   632 GSDLLQ-YGRLLLDGELHIKAHEDQKTKLRYAFVFDKILI-MVKALHIKTGDMQYTYRDSHNLAD 694
            ..|::. ...|:.:|.:...:.::..|:.|:.|:|:.::: .|..|.:.  ..:::.|:..:::|
  Rat   357 EEDIVNPANELIKEGNIQKLSAKNGTTQDRHLFLFNNVMLYCVPKLRLM--GQKFSVREKMDISD 419

  Fly   695 YRVE---QSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAME------- 749
            .:|:   :.::.||.         ::..|   |.:..|..::|.|:.:|.:.:...:|
  Rat   420 LQVQDVVKPNAARTF---------IITGR---KRSLELQTRTEEEKKEWIQVIQATVEKHKQKSE 472

  Fly   750 ---------------SLEP----------------------PGCQSTDHKMEIYTFDAPTTCRHC 777
                           ||.|                      ||.:|.....:.........|:.|
  Rat   473 TFRAFSGACTQEEEPSLSPDQPVLSAGPVEPAGVADSSGGTPGIESRKLSSKTRRDKEKPGCKSC 537

  Fly   778 SKFLKGRIHQGYRCKVCQISVHKGC 802
            .:.......:.||||:|...:.:.|
  Rat   538 GETFNSITKRRYRCKLCGEVICRKC 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	42/179 (23%)
		PH_Vav	624..753	CDD:269930	25/155 (16%)
		PH	641..749	CDD:278594	19/111 (17%)
		C1_1	761..804	CDD:278556	8/42 (19%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Fgd3	XP_008769765.1	RhoGEF	157..336	CDD:279015	42/179 (23%)
		PH-like	367..474	CDD:302622	20/120 (17%)
		PH	367..465	CDD:278594	19/111 (17%)
		FYVE_FGD3	527..580	CDD:277279	8/36 (22%)
		PH2_FGD1-4	606..710	CDD:270056
		PH	622..711	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910