Protein Alignment Vav and RtGEF

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001097184.2
• Gene: RtGEF / 35306
• FlyBaseID: FBgn0015803
• Length: 1310
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 110/513 - (21%)
• Similarity: 189/513 - (36%)
• Gaps: 130/513 - (25%)

  Fly   350 EYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTT-----DNIACNGTGYDHTNTKEEEVYQDLC--- 406
            ||:::.|.:||     ||:      .|.:|.|     |.....||..|.|...... |.:.|
  Fly    10 EYSFMGSNNDE-----LCF------QKGDVITVTQREDGGWWEGTLNDKTGWFPSN-YVNECKVQ 62

  Fly   407 -ALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERH--LNQDELRLIFP 468
             .|..|.|......   |.|..|:::|:|:|..::..|..|...|:.|:::.  |:|||...:..
  Fly    63 LPLTETIRPPEEIQ---EYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMC 124

  Fly   469 RIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFL--IYGEFCSLLLGAIDYLADVCKKN 531
            ...|:|..|...|.::.|     ...::.::||. ..|.:  ::..:|:....||..|      :
  Fly   125 NFVEIVRTHEDLLIQIEE-----CNDRVGKLFLT-SAPLMKKVHQAYCAAHPKAIVIL------D 177

  Fly   532 QIIDQLVQKCERD--YNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAM 594
            :..|:|.:..||.  ...|.|.|...||.|.:|:.||..:|.:|.:.....|.|....:|:....
  Fly   178 KYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVY 242

  Fly   595 IDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKA-HEDQKTK 658
            .|::...:..:|..:  :.:|.:...:      :...|.:|...|.::..|.:.:.| |.|
  Fly   243 KDIAATCSATRRQKE--LELQVLTGPV------RGWQGQELSTLGDIIHMGSVAVGADHRD---- 295

  Fly   659 LRYAFVFDKILIMVK-----ALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLL 718
             ||..:|.:.|:.:.     :..|..|.:..|     .:...|:|.:.:.
  Fly   296 -RYFVLFPQTLLFLSVSQRMSAFIYEGKLPLT-----GIIVNRLEDTDAL--------------- 339

  Fly   719 ARKSGKTAFTL----------YLKSEHERDKWRKALTEAMESLEPPGCQ---------STDHKME 764
                 |.||.:          ..:..:|.:||.:.|.....|| |.|.:         |..|
  Fly   340 -----KNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSL-PMGIKRQLSNLSNSSLGH--- 395

  Fly   765 IYTFDAPTTCRHCSKFLKGRIHQGY--RCKVCQISVHKGCISSTGRCKQNP--VSVPP 818
                   ....|.|:.|..|   ||  |..:|       ...|:..|...|  |::||
  Fly   396 -------LNAAHLSQHLDSR---GYCTRFSLC-------AYYSSPPCHVRPLRVTLPP 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	43/180 (24%)
		PH_Vav	624..753	CDD:269930	25/144 (17%)
		PH	641..749	CDD:278594	20/123 (16%)
		C1_1	761..804	CDD:278556	9/44 (20%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
RtGEF	NP_001097184.2	SH3_PIX	6..58	CDD:212810	16/59 (27%)
		RhoGEF	79..249	CDD:238091	44/181 (24%)
		PH_Cool_Pix	281..376	CDD:269932	20/124 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840